AbPlus™ Anti-APOE Magnetic Beads (VS-0424-XY16)
CAT#: VS-0424-XY16
The AbPlus Anti-APOE Magnetic Beads (VS-0424-XY16) is an innovative affinity resin which is bound with anti-APOE specific antibody. The beads were designed for small-scale affinity purification and immunoprecipitation (IP) of APOE protein under native and denaturing conditions.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to vesicles.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/65539/1270_D3_2_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Neuronal cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous nuclear Neuropil Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/65539/154001_B_9_5.jpg
Normal Tissue
Figure 3 High expression in liver
Hepatocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/65539/154001_A_7_4.jpg
Normal Tissue
Figure 4 Testis
Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/65539/154001_A_6_6.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enhanced (ASC diff, CACO-2, Hep G2, HSkMC, SK-MEL-30)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000130203-APOE
❮
❯
Specifications
- Applications
- Immunoprecipitation, Protein Purification
- Matrix
- Magrose bead (> 50 μmol/mL gel)
- Bead Ligand
- Anti-APOE specific antibody
- Target
- APOE
- Immunogen
- Human recombinant APOE protein (299 amino acids)
- Target Species
- Human
- Bead Capacity
- 20-30 mg/mL binding antibody
- Bead size
- 10-37 μm
- Stability
- pH 2-14
- Format
- 20% Suspension
- Buffer
- PBS, pH 7.4, with 1% BSA
- Preservative
- 0.03% Proclin 300
- Storage
- Stored at 4°C, and is stable for up to 2 years. Do not centrifuge, dry or freeze the magnetic beads.
Applications
- Application Notes
- The beads are in suspension and will settle upon storage. Prior to use, mix the vial gently (do not vortex) to ensure delivery of proper bead volume.
Target
- Introduction
- The protein encoded by this gene is a major apoprotein of the chylomicron. It binds to a specific liver and peripheral cell receptor, and is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. This gene maps to chromosome 19 in a cluster with the related apolipoprotein C1 and C2 genes. Mutations in this gene result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants.
- Alternative Names
- AD2; LPG; APO-E; ApoE4; LDLCQ5
- Gene ID
- 348
- UniProt ID
- P02649
REVIEWS AND Q&AS
CITATIONS
RESOURCES
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Precise ApoE Pull Down
We use these beads to investigate lipid metabolism in neurodegenerative disease models. They are extremely effective at pulling down ApoE from cerebrospinal fluid samples, providing us with clean samples for mass spectrometry analysis of the associated lipid profiles.
Essential For Alzheimer Research
This product has become a staple in our lab for studying Alzheimer's disease pathology. The ability to specifically isolate ApoE complexes has allowed us to better understand its interaction with amyloid-beta, yielding reproducible data for our publications.
Q&As
-
What sample types are suitable for use with these anti-ApoE beads?
A: These magnetic beads are versatile and can be used to isolate Apolipoprotein E (ApoE) from various biological samples, including plasma, cerebrospinal fluid (CSF), and cell culture lysates. This flexibility makes them a valuable tool for researching lipid metabolism and neurodegenerative diseases.
-
Why is ApoE isolation important in Alzheimer's disease research?
A: ApoE is a major genetic risk factor for Alzheimer's disease and is involved in the clearance of amyloid-beta. By isolating ApoE using these beads, researchers can study its isoforms, its interaction with amyloid plaques, and its role in lipid transport within the brain, helping to elucidate disease mechanisms.
View the frequently asked questions answered by Creative Biolabs Support.
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Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "APOE"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1659z | Mouse Anti-APOE Recombinant Antibody (clone 41D9) | WB, ELISA, FC, ICC, IF, IHC, IP | Mouse IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NABL-072 | Recombinant Anti-human APOE VHH Single Domain Antibody | WB, IHC, FC, FuncS | Llama VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0976CLV | Human Anti-APOE Recombinant Antibody (TAB-0976CLV) | ELISA, IP | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0976CLV-F(E) | Human Anti-APOE Recombinant Antibody; Fab Fragment (TAB-0976CLV-F(E)) | ELISA, IP | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0976CLV-S(P) | Human Anti-APOE Recombinant Antibody; scFv Fragment (TAB-0976CLV-S(P)) | ELISA, IP | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0669MZ | Mouse Anti-APOE Recombinant Antibody (clone F7E8) | ELISA, IHC-Fr, IHC-P, IP, WB | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-024CQ | Recombinant Mouse Anti-APOE Antibody | ELISA, BL | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0215 | Hi-Affi™ Rabbit Anti-APOE Recombinant Antibody (clone DS215AB) | FC, IHC-P, IP, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-4534 | Hi-Affi™ Rabbit Anti-APOE Recombinant Antibody (clone TH42DS) | WB, IF, ICC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-N0315-YC | Mouse Anti-APOE Recombinant Antibody (HPAB-N0315-YC) | ELISA, WB | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-N0316-YC | Mouse Anti-APOE Recombinant Antibody (HPAB-N0316-YC) | ELISA, WB | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-N0317-YC | Mouse Anti-APOE Recombinant Antibody (HPAB-N0317-YC) | IP, ELISA, WB | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-N0315-YC-S(P) | Mouse Anti-APOE Recombinant Antibody; scFv Fragment (HPAB-N0315-YC-S(P)) | ELISA, WB | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-N0316-YC-S(P) | Mouse Anti-APOE Recombinant Antibody; scFv Fragment (HPAB-N0316-YC-S(P)) | ELISA, WB | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-N0317-YC-S(P) | Mouse Anti-APOE Recombinant Antibody; scFv Fragment (HPAB-N0317-YC-S(P)) | IP, ELISA, WB | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-N0318-YC-S(P) | Mouse Anti-APOE Recombinant Antibody; scFv Fragment (HPAB-N0318-YC-S(P)) | ELISA, WB | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-N0315-YC-F(E) | Mouse Anti-APOE Recombinant Antibody; Fab Fragment (HPAB-N0315-YC-F(E)) | ELISA, WB | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-N0316-YC-F(E) | Mouse Anti-APOE Recombinant Antibody; Fab Fragment (HPAB-N0316-YC-F(E)) | ELISA, WB | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-N0317-YC-F(E) | Mouse Anti-APOE Recombinant Antibody; Fab Fragment (HPAB-N0317-YC-F(E)) | IP, ELISA, WB | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-N0318-YC-F(E) | Mouse Anti-APOE Recombinant Antibody; Fab Fragment (HPAB-N0318-YC-F(E)) | ELISA, WB | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0115CQ-F(E) | Mouse Anti-APOE Recombinant Antibody (clone 2E8); Fab Fragment | ELISA, Block | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0115CQ-S(P) | Mouse Anti-APOE Recombinant Antibody (clone 2E8); scFv Fragment | ELISA, Block | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0125-FY51 | Mouse Anti-ApoE (clone W25-2E8) scFv-Fc Chimera | ELISA, Block, SPR | Mouse IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY462 | Anti-APOE Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0625-YC24 | Recombinant Anti-APOE Eliminating Antibody, pH-Sensitive (2E8 var.) | Antigen-Sweeping In Vivo. | Mouse IgG1 kappa |
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