This product is a recombinant antibody that recognizes APP. The monoclonal antibody 2C1 reacts with the epitope of APP.
Figure 1 Comparing antibodies against Aβ3–7 in the ex vivo assay, IgG2a antibodies clear β amyloid plaque more efficiently that either the IgG1 or IgG2b isotypes.
Murine primary microglial cells were cultured with unfixed cryostat sections of PDAPP mouse brain in the presence of antibodies of different isotypes directed against Aβ3–7. Irrelevant IgG1, IgG2a, and IgG2b antibodies were used as the respective isotype-matched negative controls. After 24 h of incubation, the total level of Aβ remaining in the cultures was measured by ELISA. The two anti-Aβ IgG2a antibodies reduced Aβ levels in the cultures (69% for 2C1 and 73% for 12B4; P < 0.001) more efficiently than the IgG2b isotype antibodies (48% for 12A11, P < 0.05, and 59% for 3A3, P < 0.001). The anti-Aβ IgG1 antibodies did not significantly reduce Aβ levels. Data were analyzed with ANOVA followed by a post hoc Dunnett's test.
Bard, F., Barbour, R., Cannon, C., Carretto, R., Fox, M., Games, D., ... & Khan, K. (2003). Epitope and isotype specificities of antibodies to β-amyloid peptide for protection against Alzheimer's disease-like neuropathology. Proceedings of the National Academy of Sciences, 100(4), 2023-2028.
Figure 2 Anti-Aβ IgG2a antibodies reduced AD-like neuropathology more efficiently than other isotypes in vivo.
The percentage of frontal cortex occupied by neuritic dystrophy was determined by image analysis. The different groups within this experiment were analyzed in two sets by using the same PBS group as an internal standard (PBS-1 and PBS-2). PBS-1 was the control for the 6C6, 10D5, 12B4, and 12A11 groups, and PBS-2 was the control for the 2C1 and 3A3 groups. To compare the groups, values for individual animals are expressed as a percentage of the mean of their respective PBS control group (set at 100%). The bars represent median values, and the dashed horizontal line indicates the control level. Neuritic dystrophy was reduced significantly only by the IgG2a isotype antibodies (12B4, P < 0.05, and 2C1, P < 0.001; ANOVA followed by post hoc Dunnett's test).
Bard, F., Barbour, R., Cannon, C., Carretto, R., Fox, M., Games, D., ... & Khan, K. (2003). Epitope and isotype specificities of antibodies to β-amyloid peptide for protection against Alzheimer's disease-like neuropathology. Proceedings of the National Academy of Sciences, 100(4), 2023-2028.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
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CAT | Product Name | Application | Type |
---|---|---|---|
TAB-229 | Anti-Human Abeta Recombinant Antibody (Gantenerumab) | FuncS, IF, Neut, ELISA, FC, IP, ICC | IgG1 - kappa |
TAB-0343CL | Human Anti-APP Recombinant Antibody (TAB-0343CL) | ELISA, Inhib | Human IgG |
TAB-0344CL | Human Anti-APP Recombinant Antibody (TAB-0344CL) | ELISA | Human IgG |
TAB-0815CLV-F(E) | Human Anti-APP Recombinant Antibody; Fab Fragment (TAB-0815CLV-F(E)) | ELISA | Human Fab |
TAB-0815CLV-S(P) | Human Anti-APP Recombinant Antibody; scFv Fragment (TAB-0815CLV-S(P)) | ELISA | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
PFBL-010 | Mouse Anti-APP Recombinant Antibody (clone 12A11); Fab Fragment | WB, IF, FuncS | Mouse Fab |
PFBL-011 | Mouse Anti-APP Recombinant Antibody (clone 3D6); Fab Fragment | WB, ELISA, FuncS | Mouse Fab |
PFBL-012 | Human Anti-APP Recombinant Antibody (clone 9TL); Fab Fragment | WB, FuncS | Human Fab |
PFBL-013 | Mouse Anti-APP Recombinant Antibody (clone C705); Fab Fragment | WB, ELISA, FuncS | Mouse Fab |
PFBC-394 | Mouse Anti-APP Recombinant Antibody (clone c#6); Fab Fragment | ELISA, WB, FuncS | Mouse Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-0341CL | Mouse Anti-APP Recombinant Antibody (TAB-0341CL) | ELISA, FuncS, In vivo | Mouse IgG |
TAB-0342CL | Mouse Anti-APP Recombinant Antibody (TAB-0342CL) | ELISA, FuncS, In vivo | Mouse IgG |
TAB-252CQ | Mouse Anti-APP Recombinant Antibody (TAB-252CQ) | ELISA | Mouse IgG1 |
TAB-255CQ | Mouse Anti-APP Recombinant Antibody (TAB-255CQ) | WB | Mouse IgG |
PABX-014-S (P) | Recombinant Rabbit Anti-APP Antibody scFv Fragment (M204) | WB, ELISA, FuncS | scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-0019CL-VHH | Camelid Anti-APP Recombinant Antibody (TAB-0019CL-VHH) | IHC, WB | Camelid VHH |
TAB-0020CL-VHH | Anti-Human APP VHH Single Domain Antibody (MPL D7) | ELISA, IHC | Single domain antibody |
TAB-0021CL-VHH | Anti-Human APP VHH Single Domain Antibody (MPL C2) | ELISA, In vivo, FuncS | Single domain antibody |
TAB-0022CL-VHH | Anti-Human APP VHH Single Domain Antibody (MPL H3) | ELISA, In vivo, FuncS | Single domain antibody |
TAB-0023CL-VHH | Anti-Human APP VHH Single Domain Antibody (MPL H6) | ELISA, In vivo, FuncS | Single domain antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-253CQ-F(E) | Human Anti-APP Recombinant Antibody; Fab Fragment (TAB-253CQ-F(E)) | ELISA | Humanized Fab |
TAB-0790CLV | Mouse Anti-APP Recombinant Antibody (TAB-0790CLV) | ELISA | Humanized IgG |
TAB-0828CLV-F(E) | Human Anti-APP Recombinant Antibody; Fab Fragment (TAB-0828CLV-F(E)) | ELISA | Humanized Fab |
TAB-0829CLV-F(E) | Human Anti-APP Recombinant Antibody; Fab Fragment (TAB-0829CLV-F(E)) | ELISA | Humanized Fab |
TAB-0830CLV-F(E) | Human Anti-APP Recombinant Antibody; Fab Fragment (TAB-0830CLV-F(E)) | ELISA | Humanized Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-0789CLV | Human Anti-APP Recombinant Antibody (TAB-0789CLV) | IP | Chimeric (mouse/human) IgG |
TAB-0789CLV-F(E) | Human Anti-APP Recombinant Antibody; Fab Fragment (TAB-0789CLV-F(E)) | ELISA | Chimeric (mouse/human) Fab |
TAB-0802CLV-F(E) | Human Anti-APP Recombinant Antibody; Fab Fragment (TAB-0802CLV-F(E)) | ELISA | Chimeric (mouse/human) Fab |
TAB-0789CLV-S(P) | Mouse Anti-APP Recombinant Antibody; scFv Fragment (TAB-0789CLV-S(P)) | ELISA | Mouse scFv |
TAB-0802CLV-S(P) | Mouse Anti-APP Recombinant Antibody; scFv Fragment (TAB-0802CLV-S(P)) | ELISA | Mouse scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
BRD-0685MZ | Chicken Anti-APP Polyclonal IgY | IHC | Chicken antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
PABX-014 | Hi-Affi™ Rabbit Anti-APP Recombinant Antibody (clone M204) | WB, ELISA, FuncS | Rabbit IgG |
PABX-014-F (E) | Hi-Affi™ Rabbit Anti-APP Recombinant Antibody (clone M204); Fab Fragment | WB, ELISA, FuncS | Rabbit Fab |
MOR-0220 | Hi-Affi™ Rabbit Anti-APP Recombinant Antibody (clone DS220AB) | ELISA, WB | Rabbit IgG |
MOR-4539 | Hi-Affi™ Rabbit Anti-APP Recombinant Antibody (clone TH47DS) | IHC-P, ELISA | Rabbit IgG |
MOR-0082-FY | Rabbit Anti-APP Recombinant Antibody (clone AFY0053) | ICC, IHC-P, WB | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
EPAF-0566CQ | Mouse Anti-APP Recombinant Antibody (clone 6E10) | ELISA | Mouse IgG |
EPAF-0567CQ | Mouse Anti-APP Recombinant Antibody (clone 4G8) | ELISA, IHC | Mouse IgG2b |
EPAF-0568CQ | Human Anti-APP Recombinant Antibody (clone HyL5) | ELISA, Inhib | Human IgM |
EPAF-0569CQ | Mouse Anti-APP Recombinant Antibody (clone AB1-42) | IHC | Mouse IgG |
EPAF-0570CQ | Human Anti-APP Recombinant Antibody (clone L11.3) | IHC, ELISA, Inhib | Human IgM |
CAT | Product Name | Application | Type |
---|---|---|---|
MOB-043LC | Recombinant Mouse Anti-Mouse APP Antibody | WB, IP | Mouse IgG |
PABC-394 | Mouse Anti-APP Recombinant Antibody (clone c#6) | ELISA, WB, FuncS | Mouse IgG1 |
PABC-395 | Mouse Anti-APP Recombinant Antibody (clone c#24) | ELISA, WB, FuncS | Mouse IgG1 |
HPAB-0970-FY | Mouse Anti-APP Recombinant Antibody (HPAB-0970-FY) | ELISA | Mouse IgG |
HPAB-0971-FY | Mouse Anti-APP Recombinant Antibody (HPAB-0971-FY) | ELISA | Mouse IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
NS-001CN | Human Anti-APP Recombinant Antibody (clone AS) | WB | Human IgG |
NS-007CN | Mouse Anti-APP Recombinant Antibody (NS-007CN) | ELISA, FuncS | Mouse IgG1 |
NS-001CN-F(E) | Human Anti-APP Recombinant Antibody (clone AS); Fab Fragment | WB | Human Fab |
NS-007CN-F(E) | Mouse Anti-APP Recombinant Antibody; Fab Fragment (NS-007CN-F(E)) | ELISA | Mouse Fab |
NS-001CN-S(P) | Human Anti-APP Recombinant Antibody (clone AS); scFv Fragment | WB | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
AFC-TAB-225 | Afuco™ Anti-APP ADCC Recombinant Antibody (Bapineuzumab), ADCC Enhanced | FuncS, IF, Neut, ELISA, FC | ADCC enhanced antibody |
AFC-TAB-228 | Afuco™ Anti-APP ADCC Recombinant Antibody (Solanezumab), ADCC Enhanced | FuncS, IF, Neut, ELISA, FC | ADCC enhanced antibody |
AFC-TAB-229 | Afuco™ Anti-APP ADCC Recombinant Antibody (Gantenerumab), ADCC Enhanced | FuncS, IF, Neut, ELISA, FC, IP | ADCC enhanced antibody |
AFC-TAB-227 | Afuco™ Anti-APP ADCC Recombinant Antibody (Ponezumab), ADCC Enhanced | ELISA, IP, FC, FuncS, Neut | ADCC enhanced antibody |
AFC-TAB-226 | Afuco™ Anti-APP ADCC Recombinant Antibody (Crenezumab), ADCC Enhanced | IF, IP, Neut, FuncS, ELISA | ADCC enhanced antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0990-FY-F(E) | Mouse Anti-APP Recombinant Antibody (clone 4D4); scFv Fragment | ELISA | Mouse scFv |
HPAB-0346-FY-S(P) | Mouse Anti-APP Recombinant Antibody (clone IBL-102); scFv Fragment | Cyt, WB, ELISA | Mouse scFv |
HPAB-S0004-YC-S(P) | Human Anti-APP Recombinant Antibody (clone hu3D6); scFv Fragment | ELISA, FuncS | Human scFv |
HPAB-S0005-YC-S(P) | Human Anti-APP Recombinant Antibody (clone ch3D6); scFv Fragment | ELISA, FuncS | Human scFv |
HPAB-1828-FY-F(E) | Mouse Anti-APP Recombinant Antibody (clone 2324); scFv Fragment | ELISA | Mouse scFv |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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