Human Anti-APP Recombinant Antibody (clone h12A11v1) (CAT#: HPAB-0119CQ)

This product is a recombinant human antibody that recognizes APP. The antibody 12A11 (IgG1) captured soluble monomeric Aβ1-42.


Specific Inquiry
  • Size:
  • Conjugation:
  • Endotoxin:
  • Purity:
  • Fc Engineering:
  • Published Data
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
ELISA

Figure 1 The results from an aggregated Aβ (1-42) ELISA comparing chimeric 12A11, humanized 12A11 v1, humanized 12A11 v2, humanized 12A11 v2.1, and humanized 12A11 v3.

Figure 1 The results from an aggregated Aβ (1-42) ELISA comparing chimeric 12A11, humanized 12A11 v1, humanized 12A11 v2, humanized 12A11 v2.1, and humanized 12A11 v3.

ELISA

Figure 2 The results of a competitive Aβ1-42 ELISA binding assay comparing murine 12A11, chimeric 12A11 and h12A11 v1.

Figure 2 The results of a competitive Aβ1-42 ELISA binding assay comparing murine 12A11, chimeric 12A11 and h12A11 v1.

ELISA

Figure 3 The results of a competitive Aβ1-42 ELISA binding assay comparing murine 12A11, chimeric 12A11, h12A11 v1, h12A11 v2, h12A11 v3, and h12A11 v3.1.

Figure 3 The results of a competitive Aβ1-42 ELISA binding assay comparing murine 12A11, chimeric 12A11, h12A11 v1, h12A11 v2, h12A11 v3, and h12A11 v3.1.

CFC

Figure 4 The results of a CFC assay in which rapid improvement in cognition is observed following the administration of single doses of the humanized 12A11 antibody v3.1 h12A11 (1, 10, and 30 mg/kg) to Tg2576 mice.

Figure 4 The results of a CFC assay in which rapid improvement in cognition is observed following the administration of single doses of the humanized 12A11 antibody v3.1 h12A11 (1, 10, and 30 mg/kg) to Tg2576 mice.


Specifications

  • Host Species
  • Human
  • Derivation
  • Humanized
  • Type
  • Human IgG1
  • Specificity
  • Human APP
  • Species Reactivity
  • Human
  • Clone
  • h12A11v1
  • Applications
  • ELISA, CFC, FuncS
  • Related Disease
  • Alzheimer's disease

Product Property

  • Purity
  • >95% as determined by SDS-PAGE and HPLC analysis
  • Concentration
  • Please refer to the vial label for the specific concentration.
  • Buffer
  • PBS
  • Preservative
  • No preservatives
  • Storage
  • Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Applications

  • Application Notes
  • This antibody has been tested for use in Enzyme-linked Immunosorbent Assay and CFC assay.

Target

  • Alternative Names
  • Amyloid Beta Precursor Protein; Amyloid Beta (A4) Precursor Protein; Alzheimer Disease Amyloid Protein; Cerebral Vascular Amyloid Peptide; Amyloid Precursor Protein; Peptidase Nexin-II; Protease Nexin-II; PreA4; PN-II; ABPP; APPI; CVAP; AD1; Beta-Amyloid Precursor Protein;

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "Clone h12A11v1"

See other products for "APP"

Humanized Antibody

CAT Product Name Application Type
TAB-225 Anti-Human Abeta Recombinant Antibody (Bapineuzumab) WB, FuncS, IF, Neut, ELISA, FC, IP IgG1
TAB-226 Anti-Human Abeta Recombinant Antibody (Crenezumab) WB, IF, IP, Neut, FuncS, ELISA, FC IgG4 - kappa
TAB-227 Anti-Human Abeta Recombinant Antibody (Ponezumab) WB, ELISA, IP, FC, FuncS, Neut, IF IgG2 - kappa
TAB-253CQ Human Anti-APP Recombinant Antibody (TAB-253CQ) ELISA Humanized IgG1
TAB-0790CLV-S(P) Mouse Anti-APP Recombinant Antibody; scFv Fragment (TAB-0790CLV-S(P)) ELISA Humanized scFv

Single-domain Antibody

CAT Product Name Application Type
TAB-0019CL-VHH Camelid Anti-APP Recombinant Antibody (TAB-0019CL-VHH) IHC, WB Camelid VHH
TAB-0020CL-VHH Anti-Human APP VHH Single Domain Antibody (MPL D7) ELISA, IHC Single domain antibody
TAB-0021CL-VHH Anti-Human APP VHH Single Domain Antibody (MPL C2) ELISA, In vivo, FuncS Single domain antibody
TAB-0022CL-VHH Anti-Human APP VHH Single Domain Antibody (MPL H3) ELISA, In vivo, FuncS Single domain antibody
TAB-0023CL-VHH Anti-Human APP VHH Single Domain Antibody (MPL H6) ELISA, In vivo, FuncS Single domain antibody

Chicken IgY Antibody

CAT Product Name Application Type
BRD-0685MZ Chicken Anti-APP Polyclonal IgY IHC Chicken antibody

Recombinant Antibody

CAT Product Name Application Type
HPAB-0116CQ Mouse Anti-APP Recombinant Antibody (HPAB-0116CQ) ELISA, WB, IP, FuncS Mouse IgG1, κ
HPAB-0117CQ Human Anti-APP Recombinant Antibody (HPAB-0117CQ) ELISA, WB, IP, FuncS Human IgG1, κ
HPAB-0118CQ Human Anti-APP Recombinant Antibody (clone Fv1E4) ELISA, Inhib Human IgG
HPAB-0120CQ Human Anti-APP Recombinant Antibody (HPAB-0120CQ) ELISA, IHC, FuncS Human IgG1
HPAB-0121CQ Mouse Anti-APP Recombinant Antibody (HPAB-0121CQ) ELISA, IHC, FuncS, Migration assay, Invasion assay Mouse IgG1

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-225 Afuco™ Anti-APP ADCC Recombinant Antibody (Bapineuzumab), ADCC Enhanced FuncS, IF, Neut, ELISA, FC ADCC enhanced antibody
AFC-TAB-228 Afuco™ Anti-APP ADCC Recombinant Antibody (Solanezumab), ADCC Enhanced FuncS, IF, Neut, ELISA, FC ADCC enhanced antibody
AFC-TAB-229 Afuco™ Anti-APP ADCC Recombinant Antibody (Gantenerumab), ADCC Enhanced FuncS, IF, Neut, ELISA, FC, IP ADCC enhanced antibody
AFC-TAB-227 Afuco™ Anti-APP ADCC Recombinant Antibody (Ponezumab), ADCC Enhanced ELISA, IP, FC, FuncS, Neut ADCC enhanced antibody
AFC-TAB-226 Afuco™ Anti-APP ADCC Recombinant Antibody (Crenezumab), ADCC Enhanced IF, IP, Neut, FuncS, ELISA ADCC enhanced antibody

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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