Mouse Anti-APP Recombinant Antibody (clone 5E3) (CAT#: HPAB-0104-YJ)
This product is a recombinant mouse antibody that recognizes human APP. It may function in treating and/or preventing amyloid-beta associated diseases such as Alzheimer's disease.
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We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.
We require custom production
Figure 1 The results of Biacore™ sensorgram overlays which shows the binding of BSA-conjugated linear or comprising the SNK epitope to linear (3F5, 3G2), cyclic (5E3, 5D8) and intermediate-specific (4D11, 4D12) monoclonal antibodies, and reactivity of these antibodies to synthetic Αβ 1-42 oligomers.
Figure 2 Results of static light scatter experiments to test Αβ polymerization in the presence ("5E3") or absence ("C") of antibody 5E3.
Figure 3 The results of a neuronal toxicity analysis which shows the degree of cell survival for cells incubated with a mock control, soluble monomeric and oligomeric Αβ 1 -40 in the presence and absence of 5E3 antibody at different concentrations.
FC
Figure 4 Flow cytometry trace which shows the comparison of cells binding labelled 5E3 antibody and a negative control to the APP located at the cell surface.
SPR
Figure 5 The results of Biacore™ analysis which shows the binding to synthetic Αβ 1-42 oligomers to cyclic monoclonal antibody 5E3 at varying concentrations.
Figure 6 The results of Biacore™ sensorgram overlays which shows the binding of BSA-conjugated linear or comprising the SNK epitope to linear (3F5, 3G2), cyclic (5E3, 5D8) and intermediate-specific (4D11, 4D12) monoclonal antibodies, and reactivity of these antibodies to synthetic Αβ 1-42 oligomers.
Specifications
- Host Species
- Mouse
- Type
- Mouse IgG1
- Specificity
- Human APP
- Species Reactivity
- Human
- Clone
- 5E3
- Applications
- ELISA, WB, SPR
- Related Disease
- Alzheimer's disease
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- This antibody has been tested for use in Surface Plasmon Resonance.
Target
- Alternative Names
- AAA; AD1; PN2; ABPP; APPI; CVAP; ABETA; PN-II; preA4; CTFgamma; Amyloid-beta precursor protein; Amyloid-beta A4 protein; Alzheimer disease amyloid protein; Amyloid beta (A4) precursor protein; Amyloid beta A4 protein; Amyloid precursor protein; Beta-amyloid peptide; Beta-amyloid peptide(1-40); Beta-amyloid peptide(1-42); Beta-amyloid precursor protein; Cerebral vascular amyloid peptide; Peptidase nexin-II; Protease nexin-II; Testicular tissue protein Li 2
- Gene ID
- 351
- UniProt ID
- P05067
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-229 | Anti-Human Abeta Recombinant Antibody (TAB-229) | FuncS, IF, Neut, ELISA, FC, IP, ICC | IgG1 - kappa |
| TAB-0343CL | Human Anti-APP Recombinant Antibody (TAB-0343CL) | ELISA, Inhib | Human IgG |
| TAB-0344CL | Human Anti-APP Recombinant Antibody (TAB-0344CL) | ELISA | Human IgG |
| TAB-0783CLV-S(P) | Human Anti-APP Recombinant Antibody; scFv Fragment (TAB-0783CLV-S(P)) | ELISA, FuncS | Human scFv |
| TAB-0784CLV-S(P) | Human Anti-APP Recombinant Antibody; scFv Fragment (TAB-0784CLV-S(P)) | ELISA | Human scFv |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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