Rabbit Anti-AR Recombinant Antibody (clone R07-6E7)
CAT#: VS3-XY3265
The antibody is a recombinant rabbit antibody against Androgen Receptor (AR), which regulates eukaryotic gene expression and affects cellular proliferation and differentiation in target tissues. It has been reported for use in Western Blot, Immunohistochemistry-Paraffin, Immunocytochemistry or Immunofluorescence.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line RH-30
Immunofluorescent staining of human cell line RH-30 shows localization to cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4733/1914_G6_27_cr5c8779fe8d0bf_selected.jpg
Normal Tissue
Figure 2 Testis
Cells in seminiferous ducts Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Nuclear Leydig cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/1/135_A_6_6.jpg
Normal Tissue
Figure 3 High expression in seminal vesicle.
Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/1/135_A_9_6.jpg
RNA Expression
Figure 4 RNA cell line category: Cell line enhanced (AF22, BJ hTERT+, HAP1, LHCN-M2, RH-30, T-47d)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000169083-AR
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Specifications
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human, Mouse and Rat AR
- Species Reactivity
- Human, Mouse, Rat
- Clone
- R07-6E7
- Applications
- WB, IHC-P, ICC, IF
- Related Disease
- Androgen Insensitivity; Bulbar Muscular Atrophy, X-Linked 1
Product Property
- Clonality
- Monoclonal
- Aggregation
- < 5%
- Format
- Liquid
- Buffer
- PBS (pH 7.4), 150 mM NaCl and 50% glycerol
- Preservative
- 0.02% sodium azide
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- WB: 1/500-1/1000
IHC: 1/50-1/100
IF: 1/50-1/200
Target
- Alternative Names
- KD; AIS; AR8; TFM; DHTR; SBMA; HYSP1; NR3C4; SMAX1; HUMARA
- Gene ID
- 367
- UniProt ID
- P10275
- Long Name
- Androgen Receptor
- Sequence Similarities
- Belongs to the nuclear hormone receptor family. NR3 subfamily.
- Cellular Localization
- Cytoplasm, Nucleus
- Post Translation Modifications
- Sumoylated on Lys-388 (major) and Lys-521. Ubiquitinated. Deubiquitinated by USP26. 'Lys-6' and 'Lys-27'-linked polyubiquitination by RNF6 modulates AR transcriptional activity and specificity.
- Protein Refseq
- NP_000035.2; NP_001011645.1; NP_001334990.1
- Function
- Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation.
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Related Diseases
Prostate Cancer
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Isotype Control
- CAT
- Product Name
Recommended Dilution Buffer
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "AR"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1873z | Mouse Anti-AR Recombinant Antibody (clone 15B4) | WB, ELISA, FC, ICC, IF, IHC | Mouse IgG1 |
| ZG-0031J | Mouse Anti-AR Recombinant Antibody (ZG-0031J) | IHC-P, IF | Mouse IgG |
| ZG-0032J | Mouse Anti-AR Recombinant Antibody (ZG-0032J) | IHC-P, IF | Mouse IgG |
| VS3-XY93 | Mouse Anti-AR Recombinant Antibody (clone 2H8) | ELISA, WB, IHC | Mouse IgG1 |
| VS3-FY93 | Recombinant Mouse Anti-AR Antibody (clone 8E10-6G2-7F3) | IHC-P | Mouse IgG2b |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0226 | Hi-Affi™ Rabbit Anti-AR Recombinant Antibody (clone DS226AB) | ICC, IHC-P, IP, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1024-XY24 | Rat Anti-NHP AR Recombinant Antibody (clone AN1-15) | WB, IHC, IF | Rat IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY143 | Anti-AR Immunohistochemistry Kit | IHC | |
| VS-0525-XY485 | Anti-Mouse AR Immunohistochemistry Kit | IHC | |
| VS-0525-XY484 | Anti-Human AR Immunohistochemistry Kit | IHC | |
| VS-0525-XY486 | Anti-Monkey AR Immunohistochemistry Kit | IHC |
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