Anti-ASCL1 (clone W24V80) Recombinant Antibody Coupled Liposome (VS-1024-FY82)
CAT#: VS-1024-FY82
The ASCL1 antibody-conjugated liposomes exhibit selective cytotoxicity in the study of targeting gliomas. The design of these liposomes allows for more effective drug delivery specifically to glioma cells. Specific research indicates that the combination of liposomes with ASCL1 antibodies can enhance the recognition and killing ability against target cells.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line SH-SY5Y
Immunofluorescent staining of human cell line SH-SY5Y shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/76307/1796_F10_5_selected.jpg
Normal Tissue
Figure 2 High expression in cerebral cortex
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/29217/ihc_selected.jpg
Normal Tissue
Figure 3 Low expression in pancreas
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/29217/62863_A_1_3_val_selected.jpg
Normal Tissue
Figure 4 Cerebral cortex
Endothelial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Glial cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous Neuronal cells Staining: Not detected Intensity: Weak Quantity: <25% Location: Cytoplasmic/ membranous Neuropil Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/29217/62863_B_8_5.jpg
RNA Expression
Figure 5 RNA cell line category: Group enriched (SCLC-21H, SH-SY5Y)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000139352-ASCL1
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More Infomation
Specifications
- Potential Clinical Applications
- Glioma
Product Composition
- Clone
- W24V80
- Antibody Type
- IgG
- Antibody Host
- Mouse
- Antibody Reactivity
- Human
- Antibody Description
- The recombinant mouse antibody exhibits a highly selective binding affinity for the human ASCL1 protein. This specificity is crucial for various research applications and therapeutic strategies, as ASCL1 plays a significant role in neurogenesis and is implicated in several neurodevelopmental disorders and cancers.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- ASCL1
- Introduction
- This gene encodes a member of the basic helix-loop-helix (BHLH) family of transcription factors. The protein activates transcription by binding to the E box (5-CANNTG-3). Dimerization with other BHLH proteins is required for efficient DNA binding. This protein plays a role in the neuronal commitment and differentiation and in the generation of olfactory and autonomic neurons. Mutations in this gene may contribute to the congenital central hypoventilation syndrome (CCHS) phenotype in rare cases.
- Alternative Names
- ASCL1; achaete-scute family bHLH transcription factor 1; ASH1; HASH1; MASH1; bHLHa46; achaete-scute homolog 1; ASH-1; achaete scute protein; achaete-scute complex-like 1; achaete-scute complex homolog 1; class A basic helix-loop-helix protein 46
- Full Name
- Achaete-Scute Family BHLH Transcription Factor 1
- Gene ID
- 429
- UniProt ID
- P50553
- Cellular Localization
- Nucleus
- Post Translation Modifications
- Modification sites at PhosphoSitePlus ( P50553 )
Modification sites at neXtProt
- Protein Refseq
- NP_004307.2
- Function
- Transcription factor that plays a key role in neuronal differentiation: acts as a pioneer transcription factor, accessing closed chromatin to allow other factors to bind and activate neural pathways.
Directly binds the E box motif (5'-CANNTG-3') on promoters and promotes transcription of neuronal genes.
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Datasheet
MSDS
COA
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See other products for "ASCL1"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1209CT | Mouse Anti-ASCL1 Recombinant Antibody (clone EML200) | WB | Mouse IgG2a |
| VS13-YC70 | Rabbit Anti-ASCL1 Recombinant Antibody (VS13-YC70) | IHC-P | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-YC1216 | AbPlus™ Anti-Ascl1 Magnetic Beads (VS-0724-YC1216) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY548 | Anti-ASCL1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY549 | Anti-Mouse ASCL1 Immunohistochemistry Kit | IHC |
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