AbPlus™ Anti-AUH Magnetic Beads (VS-0724-YC258) (CAT#: VS-0724-YC258)

• Applications
• Immunoprecipitation, Protein Purification

• Matrix
• Magnetic bead

• Bead Ligand
• Anti-AUH specific antibody

• Target
• AUH

• Immunogen
• Recombinant human AUH fragment derived from E. coli.

• Target Species
• Human

• Bead Capacity
• 40 mg/mL

• Bead size
• 25 μm

• Format
• Suspension

• Concentration
• 2 mg/mL

• Buffer
• PBS, pH 7.4

• Preservative
• 0.1% Sodium azide

• Storage
• Stored at 4°C, and is stable for up to 2 years. Do not centrifuge, dry or freeze the magnetic beads.

• Application Notes
• The beads are in suspension and will settle upon storage. Prior to use, mix the vial gently (do not vortex) to ensure delivery of proper bead volume.

• Introduction
• This gene encodes bifunctional mitochondrial protein that has both RNA-binding and hydratase activities. The encoded protein is a methylglutaconyl-CoA hydratase that catalyzes the hydration of 3-methylglutaconyl-CoA to 3-hydroxy-3-methyl-glutaryl-CoA, a critical step in the leucine degradation pathway. This protein also binds AU-rich elements (AREs) found in the 3' UTRs of rapidly decaying mRNAs including c-fos, c-myc and granulocyte/macrophage colony stimulating factor. ARE elements are involved in directing RNA to rapid degradation and deadenylation. This protein is localizes to the mitochondrial matrix and the inner mitochondrial membrane and may be involved in mitochondrial protein synthesis. Mutations in this gene are the cause of 3-methylglutaconic aciduria, type I. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

• Alternative Names
• AU RNA Binding Methylglutaconyl-CoA Hydratase; AU RNA-Binding Protein/Enoyl-Coenzyme A Hydratase; AU RNA Binding Protein/Enoyl-Coenzyme A Hydratase; AU-Specific RNA-Binding Enoyl-CoA Hydratase; AU RNA Binding Protein/Enoyl-CoA Hydratase; AU-Binding Protein/Enoyl-CoA Hydratase; Itaconyl-CoA Hydratase; EC 4.2.1.18; EC 4.2.1.56;

• Gene ID
• 549

• UniProt ID
• Q13825

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