Mouse Anti-BBS4 Recombinant Antibody (VS3-FY2630) (CAT#: VS3-FY2630)

• Host Species
• Mouse

• Type
• Mouse IgG

• Specificity
• Bardet-biedl syndrome 4 of human, mouse and rat origins

• Species Reactivity
• Human, Mouse, Rat

• Applications
• WB, IHC

• Conjugate
• Unconjugated, FITC

• MW
• The molecular weight of the target protein is approximately 58.3 kDa.

• Related Disease
• Bardet-Biedl Syndrome 4 and Bardet-Biedl Syndrome

• Clonality
• Monoclonal Antibody

• Format
• Liquid

• Concentration
• Please refer to the vial label for the specific concentration.

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.

• Application Notes
• Western Blot: 1/500-1/1000
  Immunohistochemistry: 1/50-1/200

• Alternative Names
• Bardet-Biedl Syndrome 4

• Gene ID
• 585

• UniProt ID
• Q96RK4

• Sequence Similarities
• Belongs to the BBS4 family.

• Cellular Localization
• Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
  Cell projection, cilium membrane
  Cytoplasm
  Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite
  Cell projection, cilium, flagellum
  Cell projection, cilium

• Post Translation Modifications
• Ubiquitination at Lys20
  Modification sites at PhosphoSitePlus

• Protein Refseq
• XP_016877939.1; XP_016877943.1; XP_047288867.1; XP_047288868.1; XP_047288869.1

• Function
• The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia.
  The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function.
  This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome.
  Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane.
  Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane.
  The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation.

Secondary Antibody

• 2ND-040CQ
• Goat Anti-Mouse IgG (H&L) Antibody

Isotype Control

• MRO-A1591-YJ
• Mouse IgG Isotype control, Polyclonal

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