Anti-BCL2 (clone W24V44) Recombinant Antibody Coupled Liposome (VS-1024-FY47)
CAT#: VS-1024-FY47
Anti-BCL-2 antibody conjugated liposomes are targeted therapeutic agents that was designed to specifically deliver treatment to B-cell malignancies by binding to the BCL-2 protein. They aim to enhance the apoptotic response in cancer cells by overcoming the protective effects of BCL-2 overexpression, which is linked to poor prognosis and treatment resistance. This approach, along with other therapeutic strategies such as BCL-2 inhibitors and siRNA, seeks to improve treatment outcomes for patients with B-cell leukemias and lymphomas.
Anti-Bcl-2 antibody-conjugated liposomes have demonstrated significant therapeutic potential in ischemic myocardial studies. By targeting the Bcl-2 protein, these liposomes can effectively regulate apoptosis in cardiomyocytes and mitigate damage caused by myocardial ischemia. Their application in vivo can enhance the targeting and bioavailability of drugs, thereby improving therapeutic efficacy. This innovative drug delivery method offers new insights and hope for the treatment of cardiovascular diseases.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line SK-MEL-30
Immunofluorescent staining of human cell line SK-MEL-30 shows localization to nucleoplasm & nuclear membrane.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/55295/1484_G3_6_selected.jpg
Normal Tissue
Figure 2 Thyroid gland
Glandular cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/3/155167_B_3_5.jpg
Normal Tissue
Figure 3 Colon
Mucosal lymphoid cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Peripheral nerve/ganglion
Staining: High
Intensity: Strong
Quantity:>75%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/3/155167_A_7_3.jpg
Normal Tissue
Figure 4 Kidney
Cells in tubules
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/3/155167_A_8_5.jpg
Normal Tissue
Figure 5 Lymph node
Germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/3/155167_A_7_8.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enhanced (HDLM-2, HL-60, Karpas-707, U-266/70)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000171791-BCL2
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More Infomation
Specifications
- Potential Clinical Applications
- B-cell malignancies, Ischemic myocardium in vivo
Product Composition
- Clone
- W24V44
- Antibody Type
- IgG
- Antibody Host
- Mouse
- Antibody Reactivity
- Human
- Antibody Description
- This product is a recombinant antibody derived from mouse antibodies that specifically targets the BCL-2 protein. BCL-2, or B-cell lymphoma 2, is a crucial regulatory protein that plays a significant role in controlling apoptosis, or programmed cell death, which is vital for maintaining cellular homeostasis and tissue health.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- BCL2
- Introduction
- This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Alternative splicing results in multiple transcript variants.
- Alternative Names
- BCL2, Apoptosis Regulator; Protein Phosphatase 1, Regulatory Subunit 50; B-Cell CLL/Lymphoma 2; Apoptosis Regulator Bcl-2; PPP1R50; Bcl-2
- Full Name
- BCL2, Apoptosis Regulator
- Gene ID
- 596
- UniProt ID
- P10415
- Cellular Localization
- Cytoplasm, Endoplasmic reticulum, Membrane, Mitochondrion, Mitochondrion outer membrane, Nucleus
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Downloadable Resources
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Datasheet
MSDS
COA
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