Anti-BECN1 (clone W24V212) Recombinant Antibody Coupled Liposome (VS-1024-FY208)
CAT#: VS-1024-FY208
The application of anti-Beclin-1 antibody-conjugated liposomes in ischemic myocardium exhibits extensive research potential. By targeting Beclin-1, it is possible to effectively regulate the process of autophagy and promote the survival and repair of myocardial cells. In in vivo experiments, it has shown good biocompatibility and targeting ability, aiding in the precise delivery of therapeutic drugs. In the future, this technology may provide new strategies for the treatment of ischemic heart disease and has the potential to improve patient outcomes.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line SiHa
Immunofluorescent staining of human cell line SiHa shows localization to nuclear bodies & cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/3949/1891_D2_8_cr600ff296b7030_selected.jpg
Normal Tissue
Figure 2 IHC staining of human cerebellum
Immunohistochemical staining of human cerebellum shows strong cytoplasmic positivity in Purkinje cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/28949/ihc_selected.jpg
Normal Tissue
Figure 3 Lymph node
Germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10143/25093_A_9_8.jpg
Normal Tissue
Figure 4 Cerebral cortex
Neuronal cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10143/25093_B_7_5.jpg
Normal Tissue
Figure 5 Colon
Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10143/25093_A_7_3.jpg
Normal Tissue
Figure 6 Kidney
Cells in glomeruli Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Cells in tubules Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10143/25093_A_7_5.jpg
Normal Tissue
Figure 7 Testis
Cells in seminiferous ducts Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10143/25093_A_6_6.jpg
Normal Tissue
Figure 8 Placenta
Trophoblastic cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10143/25093_A_2_7.jpg
RNA Expression
Figure 9 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000126581-BECN1
❮
❯
More Infomation
Specifications
- Potential Clinical Applications
- Ischemic myocardium in vivo
Product Composition
- Clone
- W24V212
- Antibody Type
- IgG
- Antibody Host
- Mouse
- Antibody Reactivity
- Human
- Antibody Description
- This specific antibody is a recombinant mouse monoclonal antibody that has been engineered to target Beclin-1, a key protein involved in the process of autophagy. By binding selectively to Beclin-1, it can serve as a valuable tool for researchers studying cellular degradation pathways and their implications in various diseases. The high specificity of this antibody enhances the accuracy of experimental results and promotes a deeper understanding of the role of Beclin-1 in health and disease.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- BECN1
- Introduction
- This gene encodes a protein that regulates autophagy, a catabolic process of degradation induced by starvation. The encoded protein is a component of the phosphatidylinositol-3-kinase (PI3K) complex which mediates vesicle-trafficking processes. This protein is thought to play a role in multiple cellular processes, including tumorigenesis, neurodegeneration and apoptosis. Alternative splicing results in multiple transcript variants.
- Alternative Names
- Beclin 1; Coiled-Coil Myosin-Like BCL2-Interacting Protein; Beclin 1, Autophagy Related; Beclin 1 (Coiled-Coil, Moesin-Like BCL2 Interacting Protein); Beclin 1 (Coiled-Coil, Moesin-Like BCL2-Interacting Protein); ATG6 Autophagy Related 6 Homolog (S. Cerevisiae); Testis Secretory Sperm-Binding Protein Li 215e; ATG6 Autophagy Related 6 Homolog
- Full Name
- Beclin 1
- Gene ID
- 8678
- UniProt ID
- Q14457
- Cellular Localization
- Cytoplasm, Cytoplasmic vesicle, Endoplasmic reticulum, Endosome, Golgi apparatus
- Post Translation Modifications
- Phosphorylation at Thr-119 by DAPK1 reduces its interaction with BCL2 and BCL2L1 and promotes induction of autophagy. In response to autophagic stimuli, phosphorylated at serine residues by AMPK in an ATG14-dependent manner, and this phosphorylation is critical for maximally efficient autophagy.
Deubiquitinated by USP10 and USP13, leading to stabilize the PIK3C3/VPS34-containing complexes (PubMed:21962518).
Polyubiquitinated at Lys-402 with 'Lys-48'-linkages.
- Protein Refseq
- XP_005257817.1; XP_005257816.1
- Function
- Plays a central role in autophagy.
Acts as a core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2.
REVIEWS AND Q&AS
CITATIONS
RESOURCES
DOWNLOADS
RELATED PRODUCTS
Inquiry
Navs
Customer Review
There are currently no Customer reviews or questions for VS-1024-FY208. Click the button above to contact us or submit your feedback about this product.
Submit Your Publication
Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "BECN1"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2936z | Mouse Anti-BECN1 Recombinant Antibody (clone 2H3) | WB, FC, ICC, IF, IHC | Mouse IgG1 |
| ZG-0049J | Mouse Anti-BECN1 Recombinant Antibody (clone 5A11) | IHC-P, IF | Mouse IgG |
| ZG-0050J | Mouse Anti-BECN1 Recombinant Antibody (clone 5C2) | WB, IHC-P, IF | Mouse IgG |
| ZG-0051J | Mouse Anti-BECN1 Recombinant Antibody (clone 5C5) | IHC-P, IF | Mouse IgG |
| VS3-QX116 | Mouse Anti-BECN1 Recombinant Antibody (clone 5H8-7A4-5D7) | IHC | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0352 | Hi-Affi™ Rabbit Anti-BECN1 Recombinant Antibody (clone DS352AB) | IF, IHC-P, IP, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY30 | AbPlus™ Anti-BECN1 Magnetic Beads (VS-0424-XY30) | IP, Protein Purification | |
| VS-0724-YC1274 | AbPlus™ Anti-BECN1 Magnetic Beads (VS-0724-YC1274) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY238 | Anti-BECN1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY756 | Anti-Mouse BECN1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY755 | Anti-Human BECN1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY757 | Anti-Rat BECN1 Immunohistochemistry Kit | IHC |
See Our Custom Production in Action
Popular Products
-2.png)
Application: FuncS, IF, Neut, ELISA, FC, IP, ICC
Application: ELISA, IHC
Application: WB, FC, IP, ELISA, Neut, FuncS, IF
Application: WB, Neut, ELISA, IF, IP, FuncS, FC
Application: WB, ELISA, FuncS
Application: WB, IF, FuncS
Application: ELISA, IHC, FC, WB, IF, IA
Application: FC, IHC-Fr, IP, ELISA, Block
Application: ELISA, IHC, FC, IP, IF, FuncS
-3.jpg)
Application: Neut
-4.jpg)
Application: FC
Application: FC
Application: ELISA, FuncS, RIA, IP, IF, IHC, IA, Block
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
