Anti-BECN1 (clone W24V212) Recombinant Antibody Coupled Liposome (VS-1024-FY208) (CAT#: VS-1024-FY208)

• Potential Clinical Applications
• Ischemic myocardium in vivo

• Clone
• W24V212

• Antibody Type
• IgG

• Antibody Host
• Mouse

• Antibody Reactivity
• Human

• Antibody Description
• This specific antibody is a recombinant mouse monoclonal antibody that has been engineered to target Beclin-1, a key protein involved in the process of autophagy. By binding selectively to Beclin-1, it can serve as a valuable tool for researchers studying cellular degradation pathways and their implications in various diseases. The high specificity of this antibody enhances the accuracy of experimental results and promotes a deeper understanding of the role of Beclin-1 in health and disease.

• Storage
• See in the COA

• Storage Shelf Time
• See in the COA

• Target
• BECN1

• Introduction
• This gene encodes a protein that regulates autophagy, a catabolic process of degradation induced by starvation. The encoded protein is a component of the phosphatidylinositol-3-kinase (PI3K) complex which mediates vesicle-trafficking processes. This protein is thought to play a role in multiple cellular processes, including tumorigenesis, neurodegeneration and apoptosis. Alternative splicing results in multiple transcript variants.

• Alternative Names
• Beclin 1; Coiled-Coil Myosin-Like BCL2-Interacting Protein; Beclin 1, Autophagy Related; Beclin 1 (Coiled-Coil, Moesin-Like BCL2 Interacting Protein); Beclin 1 (Coiled-Coil, Moesin-Like BCL2-Interacting Protein); ATG6 Autophagy Related 6 Homolog (S. Cerevisiae); Testis Secretory Sperm-Binding Protein Li 215e; ATG6 Autophagy Related 6 Homolog

• Full Name
• Beclin 1

• Gene ID
• 8678

• UniProt ID
• Q14457

• Cellular Localization
• Cytoplasm, Cytoplasmic vesicle, Endoplasmic reticulum, Endosome, Golgi apparatus

• Post Translation Modifications
• Phosphorylation at Thr-119 by DAPK1 reduces its interaction with BCL2 and BCL2L1 and promotes induction of autophagy. In response to autophagic stimuli, phosphorylated at serine residues by AMPK in an ATG14-dependent manner, and this phosphorylation is critical for maximally efficient autophagy.
  Deubiquitinated by USP10 and USP13, leading to stabilize the PIK3C3/VPS34-containing complexes (PubMed:21962518).
  Polyubiquitinated at Lys-402 with 'Lys-48'-linkages.

• Protein Refseq
• XP_005257817.1; XP_005257816.1

• Function
• Plays a central role in autophagy.
  Acts as a core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2.

Select a product category from the dropdown menu below to view related products.