Human Anti-Beta-diketone Recombinant Antibody (clone h38c2) (CAT#: HPAB-0124CQ)
This product is a recombinant human antibody that recognizes Beta-diketone. Humanized 38C2 IgG1 was found to bind to beta-diketone haptens with conserved affinities and revealed strong catalytic activity.
Specific Inquiry
FuncS
Figure 1 Prodrug activation.
Growth inhibition of Kaposi's sarcoma cell line SLK by 10 μM prodoxorubicin 10 in the presence of 0 μM, 0.1 μM, and 1 μM m38C2 or h38C2. Bars indicate SD; n=3:
Rader, C., Turner, J. M., Heine, A., Shabat, D., Sinha, S. C., Wilson, I. A.,... & Barbas III, C. F. (2003). A humanized aldolase antibody for selective chemotherapy and adaptor immunotherapy. Journal of molecular biology, 332(4), 889-899.
FC
Figure 2 Chemical programming.
Flow cytometry histograms showing the binding of h38C2 to integrin avb3 expressing Kaposi's sarcoma cell line SLK in the presence of a twofold molar excess of β-diketone, a RGD peptidomimetic that programs m38C2 and h38C2 by covalent binding to the reactive lysine.
Rader, C., Turner, J. M., Heine, A., Shabat, D., Sinha, S. C., Wilson, I. A.,... & Barbas III, C. F. (2003). A humanized aldolase antibody for selective chemotherapy and adaptor immunotherapy. Journal of molecular biology, 332(4), 889-899.
Specifications
- Host Species
- Human
- Derivation
- Humanized
- Type
- Human IgG1
- Specificity
- Beta-diketone
- Clone
- h38c2
- Applications
- ELISA, FC, FuncS
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- This antibody has been tested for use in Flow Cytometry and Functional Assay. Please see the Published Data for further information.
Target
- Alternative Names
- Beta-diketone; β-diketone
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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ScFv Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0123CQ | Mouse Anti-Beta-diketone Recombinant Antibody (clone m38c2) | ELISA | Mouse IgG1 |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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