Recombinant Human Anti-BoNT/A Antibody (1B6) (CAT#: FAMAB-0258-CN)
This is a neutralizing antibody against botulinum neurotoxin can effectively prevent and cure the toxicosis. The mAb 1B6 can effectively inhibit the binding between BoNT/A-Hc and differentiated PC-12 cells in vitro, and the neutralization was evaluated in vivo.
Specific Inquiry
Block
Figure 1 The inhibition of 1B6 IgG4 antibodies to the interaction between BoNT/A-Hc and nerve growth factor (NGF)–treated PC-12 cells detected by a cellular immunofluorescence assay.
1B6 IgG4 antibodies were mixed with BoNT/A-Hc before incubating with the PC-12 cells, and no binding between BoNT/A-Hc and PC-12 cells was detected.
Yu, R., Wang, S., Yu, Y. Z., Du, W. S., Yang, F., Yu, W. Y., & Sun, Z. W. (2009). Neutralizing antibodies of botulinum neurotoxin serotype A screened from a fully synthetic human antibody phage display library. Journal of biomolecular screening, 14(8), 991-998.
Neut
Figure 2 In vivo toxin neutralization by C10 or 1B6 and mixture of C10 and 1B6.
Yu, R., Wang, S., Yu, Y. Z., Du, W. S., Yang, F., Yu, W. Y., & Sun, Z. W. (2009). Neutralizing antibodies of botulinum neurotoxin serotype A screened from a fully synthetic human antibody phage display library. Journal of biomolecular screening, 14(8), 991-998.
Specifications
- Immunogen
- Purified Hc fragments of botulinum neurotoxin serotype A (BoNT/A-Hc)
- Host Species
- Human
- Derivation
- scFv Phage display library
- Type
- Human IgG4
- Specificity
- Clostridium botulinum BoNT/A
- Species Reactivity
- Clostridium botulinum
- Clone
- 1B6
- Applications
- Block, Neut
Product Property
- Storage
- Store at -20°C for long-term storage. Avoid freeze/thaw cycles.
Applications
- Application Notes
- This antibody has been reported for use in Block and Neutralization. It's recommended that the optimal antibody concentration, dilution, incubition time, etc. should be carefully titrated in specific assays.
Target
- Alternative Names
- BoNT/A
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "Clone 1B6"
See other products for "BoNT/A"
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0257-CN-S(P) | Recombinant Human Anti-BoNT/A Antibody scFv Fragment (C10) | ELISA, BL | Human scFv |
| FAMAB-0258-CN-S(P) | Recombinant Human Anti-BoNT/A Antibody scFv Fragment (1B6) | ELISA, BL | Human scFv |
| HPAB-1099WJ-S(P) | Recombinant Human Anti-BoNT/A Antibody scFv Fragment (ABT01) | ELISA | Humanized scFv |
| HPAB-1100WJ-S(P) | Recombinant Human Anti-BoNT/A Antibody scFv Fragment (ABT02) | ELISA | Human scFv |
| HPAB-1101WJ-S(P) | Recombinant Human Anti-BoNT/A Antibody scFv Fragment (ABT03) | ELISA | Human scFv |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0257-CN-F(E) | Recombinant Human Anti-BoNT/A Antibody Fab Fragment (C10) | ELISA, BL | Human Fab |
| FAMAB-0258-CN-F(E) | Recombinant Human Anti-BoNT/A Antibody Fab Fragment (1B6) | ELISA, BL | Human Fab |
| FAMAB-0270-CN-F(E) | Recombinant Ovine Anti-BoNT/A Antibody Fab Fragment (scFV7) | WB, ELISA, BL | Ovine Fab |
| FAMAB-0271-CN-F(E) | Recombinant Ovine Anti-BoNT/A Antibody Fab Fragment (scFV3) | WB, ELISA, BL | Ovine Fab |
| FAMAB-0272-CN-F(E) | Recombinant Ovine Anti-BoNT/A Antibody Fab Fragment (scFV2) | WB, ELISA, BL | Ovine Fab |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1010-FY | Mouse Anti-BONT/A Recombinant Antibody (HPAB-1010-FY) | WB, ELISA, Neut | Mouse IgG |
| HPAB-1011-FY | Mouse Anti-BONT/A Recombinant Antibody (HPAB-1011-FY) | WB, ELISA, Neut | Mouse IgG |
| HPAB-1012-FY | Human Anti-BONT/A Recombinant Antibody (HPAB-1012-FY) | FC, IF, WB, Inhib | Human IgG |
| HPAB-1099WJ | Recombinant Human Anti-BoNT/A Antibody (ABT01) | ELISA | Humanized IgG1 |
| HPAB-1100WJ | Recombinant Human Anti-BoNT/A Antibody (ABT02) | ELISA | Human IgG1 |
Single-domain Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABJ-0046 | Camelid Anti-BoNT/A Recombinant Antibody (PABJ-0046) | ELISA | Camelid VHH |
| PABJ-0047 | Camelid Anti-BoNT/A Recombinant Antibody (PABJ-0047) | ELISA | Camelid VHH |
Customer Reviews and Q&As
There are currently no Customer reviews or questions for FAMAB-0258-CN. Click the button above to contact us or submit your feedback about this product.
View the frequently asked questions answered by Creative Biolabs Support.
For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.