Rabbit Anti-BRD2 Recombinant Antibody (clone R05-7E0) (CAT#: VS3-FY1670)

• Immunogen
• Synthetic peptide of human BRD2

• Host Species
• Rabbit

• Type
• Rabbit IgG

• Specificity
• Human and Rat BRD2

• Species Reactivity
• Human, Rat

• Clone
• R05-7E0

• Applications
• Western Blot

• MW
• The calculated weight of the target protein is approximately 88 kDa, while the observed molecular weight stands at 110 kDa.

• Related Disease
• Epilepsy, Myoclonic Juvenile and Nut Midline Carcinoma

• Purification
• Affinity Purified

• Format
• Liquid

• Concentration
• Please refer to the vial label for the specific concentration.

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Application Notes
• Western Blot: 1/500-1/1000

• Alternative Names
• Bromodomain Containing 2; Really Interesting New Gene 3 Protein; BRD2 Intronic Transcript 1; O27.1.1; RING3; Female Sterile Homeotic-Related Gene 1; Bromodomain-Containing Protein 2; Bromodomain-Containing 2

• Gene ID
• 6046

• UniProt ID
• P25440

• Sequence Similarities
• Belongs to the BET family.

• Cellular Localization
• Chromosome, Nucleus

• Post Translation Modifications
• Acetylation
  Phosphoprotein

• Protein Refseq
• XP_047275178.1; XP_047275179.1; XP_054185819.1; XP_054185820.1; XP_054186593.1

• Function
• Chromatin reader protein that specifically recognizes and binds histone H4 acetylated at 'Lys-5' and 'Lys-12' (H4K5ac and H4K12ac, respectively), thereby controlling gene expression and remodeling chromatin structures.
  Recruits transcription factors and coactivators to target gene sites, and activates RNA polymerase II machinery for transcriptional elongation.
  Plays a key role in genome compartmentalization via its association with CTCF and cohesin: recruited to chromatin by CTCF and promotes formation of topologically associating domains (TADs) via its ability to bind acetylated histones, contributing to CTCF boundary formation and enhancer insulation.
  Also recognizes and binds acetylated non-histone proteins, such as STAT3.
  Involved in inflammatory response by regulating differentiation of naive CD4⁺ T-cells into T-helper Th17: recognizes and binds STAT3 acetylated at 'Lys-87', promoting STAT3 recruitment to chromatin.

Isotype Control

• MOB-208CQ
• Rabbit IgG Isotype Control Antibody

Secondary Antibody

• 2ND-054CQ
• Goat Anti-Rabbit IgG Antibody, R-PE

• 2ND-059CQ
• Goat Anti-Rabbit IgG (H&L) Antibody

• 2ND-055CQ
• Chicken Anti-Rabbit IgG (H&L) Antibody

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