Anti-BSG (clone Gavilimomab) Recombinant Antibody Coupled Liposome (VS-1024-FY297)
CAT#: VS-1024-FY297
Anti-CD147 antibody conjugated liposomes have the potential to enhance targeted drug delivery in prostate cancer treatment, improving therapeutic efficacy while minimizing off-target effects. By leveraging the specific binding of the antibody to CD147, which is often overexpressed in cancer cells, these liposomes can facilitate precise localization of chemotherapeutic agents directly to tumor sites.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line HEK 293
Immunofluorescent staining of human cell line HEK 293 shows localization to vesicles.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/74870/1466_A2_3_selected.jpg
Normal Tissue
Figure 2 Testis
Sertoli cells Staining: High Intensity: Strong Quantity:>75%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2427/6189_A_4_6.jpg
Normal Tissue
Figure 3 Heart muscle
Cardiomyocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2427/6189_B_6_6.jpg
Normal Tissue
Figure 4 Cerebral cortex
Endothelial cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2427/6189_B_7_5.jpg
Normal Tissue
Figure 5 Colon
Endocrine cells Staining: High Intensity: Strong Enterocytes Staining: High Intensity: Strong Quantity: 75%-25% Enterocytes - Goblet cells Staining: High Intensity: Strong Quantity: 75%-25%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2427/6189_A_7_3.jpg
Normal Tissue
Figure 6 Kidney
Collecting ducts Staining: Medium Intensity: Strong Quantity: <25% Distal tubules Staining: High Intensity: Strong Quantity: 75%-25%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2427/6189_A_7_5.jpg
RNA Expression
Figure 7 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000172270-BSG
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More Infomation
Specifications
- Potential Clinical Applications
- Prostate cancer
Product Composition
- Clone
- Gavilimomab
- Antibody Type
- IgM
- Antibody Host
- Mouse
- Antibody Reactivity
- Human
- Antibody Description
- This is a recombinant mouse monoclonal antibody that was specifically tailored to target CD147, a glycoprotein that plays a critical role in tumor progression and the regulation of the extracellular matrix. With its ability to bind to CD147, this antibody represents a valuable asset for studying the protein's functions in cancer biology and inflammatory processes. Researchers can leverage this antibody to delve deeper into the therapeutic implications of CD147, enhancing our understanding of its contributions to various diseases.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- BSG
- Introduction
- The protein encoded by this gene is a plasma membrane protein that is important in spermatogenesis, embryo implantation, neural network formation, and tumor progression. The encoded protein is also a member of the immunoglobulin superfamily. Multiple transcript variants encoding different isoforms have been found for this gene.
- Alternative Names
- Gavilimomab; 244096-20-6; ABX-CBL; ABX-CBL; BSG; basigin (Ok blood group); basigin (OK blood group), OK; basigin
- Full Name
- Basigin (Ok Blood Group)
- Gene ID
- 682
- UniProt ID
- P35613
- Cellular Localization
- Cell membrane; Cell projection; Endoplasmic reticulum; Endosome; Membrane
- Post Translation Modifications
- Isoform 2: N-glycosylated.
Isoform 3: N-glycosylated.
Isoform 4: N-glycosylated.
- Protein Refseq
- NP_001309172.1; NP_001719.2; NP_940991.1
- Function
- Isoform 1:
Essential for normal retinal maturation and development (By similarity).
Acts as a retinal cell surface receptor for NXNL1 and plays an important role in NXNL1-mediated survival of retinal cone photoreceptors (PubMed:25957687).
In association with glucose transporter SLC16A1/GLUT1 and NXNL1, promotes retinal cone survival by enhancing aerobic glycolysis and accelerating the entry of glucose into photoreceptors (PubMed:25957687).
May act as a potent stimulator of IL6 secretion in multiple cell lines that include monocytes (PubMed:21620857).
Isoform 2
Signaling receptor for cyclophilins, essential for PPIA/CYPA and PPIB/CYPB-dependent signaling related to chemotaxis and adhesion of immune cells (PubMed:11943775, PubMed:11688976).
Plays an important role in targeting monocarboxylate transporters SLC16A1/GLUT1, SLC16A11 and SLC16A12 to the plasma membrane (PubMed:17127621, PubMed:21778275, PubMed:28666119).
Acts as a coreceptor for vascular endothelial growth factor receptor 2 (KDR/VEGFR2) in endothelial cells enhancing its VEGFA-mediated activation and downstream signaling (PubMed:25825981).
Promotes angiogenesis through EPAS1/HIF2A-mediated up-regulation of VEGFA (isoform VEGF-165 and VEGF-121) and KDR/VEGFR2 in endothelial cells (PubMed:19837976).
Plays a key role in regulating tumor growth, invasion, metastasis and neoangiogenesis by stimulating the production and release of extracellular matrix metalloproteinases and KDR/VEGFR2 by both tumor cells and stromal cells (fibroblasts and endothelial cells) (PubMed:12553375, PubMed:11992541, PubMed:15833850).
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Datasheet
MSDS
COA
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|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBL-082 | Human Anti-BSG Recombinant Antibody (clone 4A5); scFv Fragment | WB, ELISA, FuncS | Human scFv |
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| HPAB-3188LY-S(P) | Human Anti-BSG Recombinant Antibody (clone hPPAT-082-01); scfv Fragment | ELISA, FC | Humanized scfv |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBL-082 | Human Anti-BSG Recombinant Antibody (clone 4A5); Fab Fragment | WB, ELISA, FuncS | Human Fab |
| HPAB-0126CQ-F(E) | Mouse Anti-BSG Recombinant Antibody (clone HAb18); Fab Fragment | ELISA, IF | Mouse Fab |
| PFBC-403 | Mouse Anti-BSG Recombinant Antibody (clone 6H8); Fab Fragment | ELISA, FC | Mouse Fab |
| HPAB-3079LY-F(E) | Mouse Anti-BSG Recombinant Antibody; Fab Fragment (HPAB-3079LY-F(E)) | IHC, Inhib | Mouse Fab |
| HPAB-0356-FY-F(E) | Human Anti-BSG Recombinant Antibody Fab Fragment (HPAB-0356-FY-F(E)) | Inhib | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABL-464 | Human Anti-BSG Recombinant Antibody (clone 5F6) | WB, FuncS | Chimeric (mouse/human) IgG |
| MOB-1965MZ | Mouse Anti-BSG Recombinant Antibody (clone WK2/0) | FC | Mouse IgG1 |
| FAMAB-0033CQ | Mouse Anti-BSG Recombinant Antibody (FAMAB-0033CQ) | ELISA, Block | Mouse IgG1, κ |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1285CL | Anti-Human BSG Recombinant Antibody (2.6.1 (ABX-RB2)) | Inhib | Fully human antibody |
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| TAB-1288CL | Human Anti-BSG Recombinant Antibody (TAB-1288CL) | Cyt, FC | Human IgG |
| TAB-1289CL | Human Anti-BSG Recombinant Antibody (TAB-1289CL) | Cyt, FC | Human IgG |
| TAB-1290CL | Human Anti-BSG Recombinant Antibody (TAB-1290CL) | Cyt, FC | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-070CQ | Human Anti-BSG Recombinant Antibody (clone Ab-1) | ELISA, Block | Human IgG1, κ |
| NEUT-071CQ | Mouse Anti-BSG Recombinant Antibody (clone HIM6) | FC, WB, IHC, Block | Mouse IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0389 | Hi-Affi™ Rabbit Anti-BSG Recombinant Antibody (clone DS389AB) | ICC, IHC-P, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NS-020CN | Mouse Anti-BSG Recombinant Antibody (clone 5F6) | ELISA, Block, FuncS | Mouse IgG1 |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-156 | Afuco™ Anti-BSG ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-156) | FuncS, IF, Neut, ELISA, FC, IP | ADCC enhanced antibody |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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