Human Anti-BSG Recombinant Antibody (VS-0524-YC43)
CAT#: VS-0524-YC43
The antibody is capable of specifically recognizing human basigin (Ok blood group) and a cancer cell expressing basigin protein. The antibody exhibited a damaging effect by the ADCC activity.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line HEK 293
Immunofluorescent staining of human cell line HEK 293 shows localization to vesicles.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/74870/1466_A2_3_selected.jpg
Normal Tissue
Figure 2 Testis
Sertoli cells Staining: High Intensity: Strong Quantity:>75%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2427/6189_A_4_6.jpg
Normal Tissue
Figure 3 Heart muscle
Cardiomyocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2427/6189_B_6_6.jpg
Normal Tissue
Figure 4 Cerebral cortex
Endothelial cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2427/6189_B_7_5.jpg
Normal Tissue
Figure 5 Colon
Endocrine cells Staining: High Intensity: Strong Enterocytes Staining: High Intensity: Strong Quantity: 75%-25% Enterocytes - Goblet cells Staining: High Intensity: Strong Quantity: 75%-25%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2427/6189_A_7_3.jpg
Normal Tissue
Figure 6 Kidney
Collecting ducts Staining: Medium Intensity: Strong Quantity: <25% Distal tubules Staining: High Intensity: Strong Quantity: 75%-25%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2427/6189_A_7_5.jpg
RNA Expression
Figure 7 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000172270-BSG
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Specifications
- Host Species
- Human
- Type
- Human IgG1
- Specificity
- Human basigin (Ok blood group)
- Species Reactivity
- Human
- Applications
- FC, ADCC
Product Property
- Purification
- Protein A purified
- Purity
- >95%
- Buffer
- PBS, pH 7.4
- Preservative
- No preservative
- Storage
- Centrifuge briefly prior to opening vial. Store at 4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- OK; 5F7; TCSF; CD147; EMPRIN; HAb18G; EMMPRIN
- Gene ID
- 682
- UniProt ID
- P35613
- Long Name
- basigin (Ok blood group)
- Cellular Localization
- Cell membrane; Cell projection; Endoplasmic reticulum; Endosome; Membrane
- Post Translation Modifications
- Isoform 2: N-glycosylated.
Isoform 3: N-glycosylated.
Isoform 4: N-glycosylated.
- Protein Refseq
- NP_001309172.1; NP_001719.2; NP_940991.1
- Function
- Isoform 1:
Essential for normal retinal maturation and development (By similarity).
Acts as a retinal cell surface receptor for NXNL1 and plays an important role in NXNL1-mediated survival of retinal cone photoreceptors (PubMed:25957687).
In association with glucose transporter SLC16A1/GLUT1 and NXNL1, promotes retinal cone survival by enhancing aerobic glycolysis and accelerating the entry of glucose into photoreceptors (PubMed:25957687).
May act as a potent stimulator of IL6 secretion in multiple cell lines that include monocytes (PubMed:21620857).
Isoform 2
Signaling receptor for cyclophilins, essential for PPIA/CYPA and PPIB/CYPB-dependent signaling related to chemotaxis and adhesion of immune cells (PubMed:11943775, PubMed:11688976).
Plays an important role in targeting monocarboxylate transporters SLC16A1/GLUT1, SLC16A11 and SLC16A12 to the plasma membrane (PubMed:17127621, PubMed:21778275, PubMed:28666119).
Acts as a coreceptor for vascular endothelial growth factor receptor 2 (KDR/VEGFR2) in endothelial cells enhancing its VEGFA-mediated activation and downstream signaling (PubMed:25825981).
Promotes angiogenesis through EPAS1/HIF2A-mediated up-regulation of VEGFA (isoform VEGF-165 and VEGF-121) and KDR/VEGFR2 in endothelial cells (PubMed:19837976).
Plays a key role in regulating tumor growth, invasion, metastasis and neoangiogenesis by stimulating the production and release of extracellular matrix metalloproteinases and KDR/VEGFR2 by both tumor cells and stromal cells (fibroblasts and endothelial cells) (PubMed:12553375, PubMed:11992541, PubMed:15833850).
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| IAB-B050(A) | Recombinant Anti-human BSG Intrabody [(D-Arg)9] | WB, ICC, Neut, FuncS | scFv-(D-Arg)9 |
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| IAB-B050(T) | Recombinant Anti-human BSG Intrabody [Tat] | WB, ICC, FuncS | scFv-Tat |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-156 | Anti-Human CD147 Recombinant Antibody (TAB-156) | FuncS, IF, Neut, ELISA, FC, IP, ICC | IgM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-883 | Anti-Human CD147/BSG Recombinant Antibody (TAB-883) | WB, IF, IP, Neut, FuncS, ELISA, FC | IgM |
| TAB-1285CL | Anti-Human BSG Recombinant Antibody (2.6.1 (ABX-RB2)) | Inhib | Fully human antibody |
| TAB-1287CL | Human Anti-BSG Recombinant Antibody (TAB-1287CL) | Cyt, FC | Human IgG |
| TAB-1288CL | Human Anti-BSG Recombinant Antibody (TAB-1288CL) | Cyt, FC | Human IgG |
| TAB-1289CL | Human Anti-BSG Recombinant Antibody (TAB-1289CL) | Cyt, FC | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABL-082 | Human Anti-BSG Recombinant Antibody (clone 4A5) | WB, ELISA, FuncS | Human IgG |
| HPAB-3079LY | Mouse Anti-BSG Recombinant Antibody (HPAB-3079LY) | IHC, Inhib | Mouse IgG |
| HPAB-3080LY | Human Anti-BSG Recombinant Antibody (HPAB-3080LY) | IHC, Inhib | Chimeric (mouse/human) IgG |
| VS3-WK1445 | Mouse Anti-BSG Recombinant Antibody (clone TBM6) | FC, IF | Mouse IgG1 |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBL-082 | Human Anti-BSG Recombinant Antibody (clone 4A5); scFv Fragment | WB, ELISA, FuncS | Human scFv |
| PSBL-461 | Mouse Anti-BSG Recombinant Antibody (clone 5F6); scFv Fragment | WB, FuncS | Mouse scFv |
| FAMAB-0033CQ-S(P) | Mouse Anti-BSG Recombinant Antibody scFv Fragment (FAMAB-0033CQ-S(P)) | ELISA, Block | Mouse scFv |
| HPAB-0126CQ-S(P) | Mouse Anti-BSG Recombinant Antibody (clone HAb18); scFv Fragment | ELISA, IF | Mouse scFv |
| HPAB-0356-FY-S(P) | Human Anti-BSG Recombinant Antibody scFv Fragment (HPAB-0356-FY-S(P)) | Inhib | Humanized scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-070CQ | Human Anti-BSG Recombinant Antibody (clone Ab-1) | ELISA, Block | Human IgG1, κ |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0389 | Hi-Affi™ Rabbit Anti-BSG Recombinant Antibody (clone DS389AB) | ICC, IHC-P, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NS-020CN | Mouse Anti-BSG Recombinant Antibody (clone 5F6) | ELISA, Block, FuncS | Mouse IgG1 |
| NS-020CN-F(E) | Mouse Anti-BSG Recombinant Antibody (clone 5F6); Fab Fragment | ELISA | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0033CQ-F(E) | Mouse Anti-BSG Recombinant Antibody Fab Fragment (FAMAB-0033CQ-F(E)) | ELISA, Block | Mouse Fab |
| FAMAB-0034CQ-F(E) | Human Anti-BSG Recombinant Antibody Fab Fragment (FAMAB-0034CQ-F(E)) | ELISA, Block | Chimeric (mouse/human) Fab |
| HPAB-0126CQ-F(E) | Mouse Anti-BSG Recombinant Antibody (clone HAb18); Fab Fragment | ELISA, IF | Mouse Fab |
| PFBC-403 | Mouse Anti-BSG Recombinant Antibody (clone 6H8); Fab Fragment | ELISA, FC | Mouse Fab |
| HPAB-3188LY-F(E) | Human Anti-BSG Recombinant Antibody (clone hPPAT-082-01); Fab Fragment | ELISA, FC | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-156 | Afuco™ Anti-BSG ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-156) | FuncS, IF, Neut, ELISA, FC, IP | ADCC enhanced antibody |
| AFC-TAB-883 | Afuco™ Anti-BSG ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-883) | IF, IP, Neut, FuncS, ELISA | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-YC1484 | AbPlus™ Anti-BSG Magnetic Beads (VS-0724-YC1484) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0125-FY33 | Human Anti-BSG (clone HAb18) scFv-Fc Chimera | ELISA, IF, WB | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC238 | Recombinant Anti-BSG Vesicular Antibody, EV Displayed (VS-0425-YC238) | ELISA, FC, Neut, Cell-uptake |
| CAT | Product Name | Application | Type |
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| VS-0525-XY837 | Anti-Mouse BSG Immunohistochemistry Kit | IHC | |
| VS-0525-XY838 | Anti-Rat BSG Immunohistochemistry Kit | IHC |
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