Human Anti-BSG Recombinant Antibody (VS-0524-YC43) (CAT#: VS-0524-YC43)

• Host Species
• Human

• Type
• Human IgG1

• Specificity
• Human basigin (Ok blood group)

• Species Reactivity
• Human

• Applications
• FC, ADCC

• Purification
• Protein A purified

• Purity
• >95%

• Buffer
• PBS, pH 7.4

• Preservative
• No preservative

• Storage
• Centrifuge briefly prior to opening vial. Store at 4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.

• Alternative Names
• OK; 5F7; TCSF; CD147; EMPRIN; HAb18G; EMMPRIN

• Gene ID
• 682

• UniProt ID
• P35613

• Long Name
• basigin (Ok blood group)

• Cellular Localization
• Cell membrane; Cell projection; Endoplasmic reticulum; Endosome; Membrane

• Post Translation Modifications
• Isoform 2: N-glycosylated.
  Isoform 3: N-glycosylated.
  Isoform 4: N-glycosylated.

• Protein Refseq
• NP_001309172.1; NP_001719.2; NP_940991.1

• Function
• Isoform 1:
  Essential for normal retinal maturation and development (By similarity).
  Acts as a retinal cell surface receptor for NXNL1 and plays an important role in NXNL1-mediated survival of retinal cone photoreceptors (PubMed:25957687).
  In association with glucose transporter SLC16A1/GLUT1 and NXNL1, promotes retinal cone survival by enhancing aerobic glycolysis and accelerating the entry of glucose into photoreceptors (PubMed:25957687).
  May act as a potent stimulator of IL6 secretion in multiple cell lines that include monocytes (PubMed:21620857).
  
  Isoform 2
  Signaling receptor for cyclophilins, essential for PPIA/CYPA and PPIB/CYPB-dependent signaling related to chemotaxis and adhesion of immune cells (PubMed:11943775, PubMed:11688976).
  Plays an important role in targeting monocarboxylate transporters SLC16A1/GLUT1, SLC16A11 and SLC16A12 to the plasma membrane (PubMed:17127621, PubMed:21778275, PubMed:28666119).
  Acts as a coreceptor for vascular endothelial growth factor receptor 2 (KDR/VEGFR2) in endothelial cells enhancing its VEGFA-mediated activation and downstream signaling (PubMed:25825981).
  Promotes angiogenesis through EPAS1/HIF2A-mediated up-regulation of VEGFA (isoform VEGF-165 and VEGF-121) and KDR/VEGFR2 in endothelial cells (PubMed:19837976).
  Plays a key role in regulating tumor growth, invasion, metastasis and neoangiogenesis by stimulating the production and release of extracellular matrix metalloproteinases and KDR/VEGFR2 by both tumor cells and stromal cells (fibroblasts and endothelial cells) (PubMed:12553375, PubMed:11992541, PubMed:15833850).

Isotype Control

• MOB-173CQ
• Human IgG1, lambda Isotype Control Antibody

• MOB-0402ZL
• Human IgG1, kappa - Isotype Control Antibody

Secondary Antibody

• 2ND-025CQ
• Rabbit Anti-Human IgG (H&L) Antibody

• 2ND-024CQ
• Goat Anti-Human IgG (H&L) Antibody

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