Mouse Anti-BST2 Recombinant Antibody (VS3-FY2638) (CAT#: VS3-FY2638)

• Host Species
• Mouse

• Type
• Mouse IgG

• Specificity
• Bone marrow stromal cell antigen 2 of human

• Species Reactivity
• Human

• Applications
• IHC, ICC, FC, ELISA

• Conjugate
• Unconjugated, FITC

• MW
• The molecular weight of the target protein is approximately 19.8 kDa.

• Related Disease
• Stomatitis and Colorado Tick Fever

• Clonality
• Monoclonal Antibody

• Format
• Liquid

• Concentration
• Please refer to the vial label for the specific concentration.

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.

• Application Notes
• Immunohistochemistry: 1/50-1/200
  Immunocytochemistry: 1/50-1/200
  Flow cytometry: 1/50-1/200
  ELISA: 1/1000-1/10000

• Alternative Names
• Bone Marrow Stromal Cell Antigen 2; HM1.24 Antigen; TETHERIN; BST-2; Bone Marrow Stromal Antigen 2; CD317 Antigen; NPC-A-7; CD317

• Gene ID
• 684

• Sequence Similarities
• Belongs to the tetherin family.

• Cellular Localization
• Golgi apparatus, trans-Golgi network
  Cell membrane; Single-pass type II membrane protein
  Cell membrane; Lipid-anchor, GPI-anchor
  Membrane raft
  Cytoplasm
  Apical cell membrane

• Post Translation Modifications
• Monoubiquitinated by KSHV E3 ubiquitin-protein ligase K5, leading to its targeting to late endosomes and degradation.
  The GPI anchor is essential for its antiviral activity.
  Glycosylation at Asn65, Asn92, Thr121, Thr122, and Ser131
  Ubiquitination at Lys18
  Modification sites at PhosphoSitePlus
  Glycosylation from Gly
  Glycosylation from GlyGen 6 sites, 9 N-linked glycans (2 sites), 2 O-linked glycans (4 sites)

• Protein Refseq
• NP_004326.1

• Function
• Acts as a direct physical tether, holding virions to the cell membrane and linking virions to each other.
  The tethered virions can be internalized by endocytosis and subsequently degraded or they can remain on the cell surface.
  In either case, their spread as cell-free virions is restricted.

Secondary Antibody

• 2ND-040CQ
• Goat Anti-Mouse IgG (H&L) Antibody

Isotype Control

• MRO-A1591-YJ
• Mouse IgG Isotype control, Polyclonal

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