Anti-BTK (clone W24V45) Recombinant Antibody Coupled Liposome (VS-1024-FY48) (CAT#: VS-1024-FY48)

• Potential Clinical Applications
• B-cell malignancies

• Clone
• W24V45

• Antibody Type
• IgG

• Antibody Host
• Mouse

• Antibody Reactivity
• Human

• Antibody Description
• This product is a recombinant mouse monoclonal antibody that was specifically designed to target Bruton's Tyrosine Kinase (BTK). BTK is a crucial enzyme involved in various signaling pathways, particularly in immune cell development and function. The antibody has been engineered using advanced recombinant DNA technology, ensuring high specificity and affinity for its intended target.

• Storage
• See in the COA

• Storage Shelf Time
• See in the COA

• Target
• BTK

• Introduction
• The protein encoded by this gene plays a crucial role in B-cell development. Mutations in this gene cause X-linked agammaglobulinemia type 1, which is an immunodeficiency characterized by the failure to produce mature B lymphocytes, and associated with a failure of Ig heavy chain rearrangement. Alternative splicing results in multiple transcript variants encoding different isoforms.

• Alternative Names
• Bruton Tyrosine Kinase; Bruton Agammaglobulinemia Tyrosine Kinase; B-Cell Progenitor Kinase; Brutons Tyrosine Kinase; EC 2.7.10.2; AGMX1; ATK; BPK; Tyrosine-Protein Kinase BTK Isoform (Lacking Exon 13 To 17); Dominant-Negative Kinase-Deficient Brutons Tyrosine Kinase; Tyrosine-Protein Kinase BTK Isoform (Lacking Exon 14)

• Full Name
• Bruton Tyrosine Kinase

• Gene ID
• 695

• UniProt ID
• Q06187

• Sequence Similarities
• Belongs to the protein kinase superfamily. Tyr protein kinase family. TEC subfamily.

• Cellular Localization
• Cytoplasm, Nucleus, Cell membrane; Peripheral membrane protein; Synapse

• Post Translation Modifications
• Ubiquitination at Lys322 and Lys406 ( NX_Q06187 [NX_Q06187-1] )
  Modification sites at PhosphoSitePlus ( Q06187 )
  Glycosylation from GlyGen (Q06187) 1 site, 1 O-linked glycan (1 site)

• Protein Refseq
• NP_000052.1; NP_001274273.1; NP_001274274.1

• Function
• Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling (PubMed:19290921).
  Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation (PubMed:19290921).
  After BCR engagement and activation at the plasma membrane, phosphorylates PLCG2 at several sites, igniting the downstream signaling pathway through calcium mobilization, followed by activation of the protein kinase C (PKC) family members (PubMed:11606584).
  PLCG2 phosphorylation is performed in close cooperation with the adapter protein B-cell linker protein BLNK (PubMed:11606584).
  BTK acts as a platform to bring together a diverse array of signaling proteins and is implicated in cytokine receptor signaling pathways.

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