Anti-BTK (clone W24V45) Recombinant Antibody Coupled Liposome (VS-1024-FY48)
CAT#: VS-1024-FY48
Anti-BTK antibody-coupled liposomes represent a novel therapeutic approach targeting B cell receptor (BCR) signaling in B cell malignancies. These liposomes can deliver cytotoxic drugs or other therapeutic agents specifically to B cells, exploiting the overexpression of Bruton's tyrosine kinase (BTK) in cancerous B cells. By coupling anti-BTK antibodies to liposomes, this strategy allows for selective targeting of malignant B cells while sparing healthy cells, potentially reducing side effects.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line HEL
Immunofluorescent staining of human cell line HEL shows localization to plasma membrane & cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2028/1770_B11_1_selected.jpg
Normal Tissue
Figure 2 Colon
Enterocytes - Mucosal lymphoid cells Staining: High Intensity: Strong Quantity:>75%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/1198/2770_A_9_3.jpg
Normal Tissue
Figure 3 High expression in lymph node
Germinal center cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/1198/2770_A_8_8.jpg
Normal Tissue
Figure 4 Spleen
Cells in red pulp Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous Cells in white pulp Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/1198/2770_B_8_4.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enhanced (Daudi, HEL, HMC-1, U-937)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000010671-BTK
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More Infomation
Specifications
- Potential Clinical Applications
- B-cell malignancies
Product Composition
- Clone
- W24V45
- Antibody Type
- IgG
- Antibody Host
- Mouse
- Antibody Reactivity
- Human
- Antibody Description
- This product is a recombinant mouse monoclonal antibody that was specifically designed to target Bruton's Tyrosine Kinase (BTK). BTK is a crucial enzyme involved in various signaling pathways, particularly in immune cell development and function. The antibody has been engineered using advanced recombinant DNA technology, ensuring high specificity and affinity for its intended target.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- BTK
- Introduction
- The protein encoded by this gene plays a crucial role in B-cell development. Mutations in this gene cause X-linked agammaglobulinemia type 1, which is an immunodeficiency characterized by the failure to produce mature B lymphocytes, and associated with a failure of Ig heavy chain rearrangement. Alternative splicing results in multiple transcript variants encoding different isoforms.
- Alternative Names
- Bruton Tyrosine Kinase; Bruton Agammaglobulinemia Tyrosine Kinase; B-Cell Progenitor Kinase; Brutons Tyrosine Kinase; EC 2.7.10.2; AGMX1; ATK; BPK; Tyrosine-Protein Kinase BTK Isoform (Lacking Exon 13 To 17); Dominant-Negative Kinase-Deficient Brutons Tyrosine Kinase; Tyrosine-Protein Kinase BTK Isoform (Lacking Exon 14)
- Full Name
- Bruton Tyrosine Kinase
- Gene ID
- 695
- UniProt ID
- Q06187
- Sequence Similarities
- Belongs to the protein kinase superfamily. Tyr protein kinase family. TEC subfamily.
- Cellular Localization
- Cytoplasm, Nucleus, Cell membrane; Peripheral membrane protein; Synapse
- Post Translation Modifications
- Ubiquitination at Lys322 and Lys406 ( NX_Q06187 [NX_Q06187-1] )
Modification sites at PhosphoSitePlus ( Q06187 )
Glycosylation from GlyGen (Q06187) 1 site, 1 O-linked glycan (1 site)
- Protein Refseq
- NP_000052.1; NP_001274273.1; NP_001274274.1
- Function
- Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling (PubMed:19290921).
Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation (PubMed:19290921).
After BCR engagement and activation at the plasma membrane, phosphorylates PLCG2 at several sites, igniting the downstream signaling pathway through calcium mobilization, followed by activation of the protein kinase C (PKC) family members (PubMed:11606584).
PLCG2 phosphorylation is performed in close cooperation with the adapter protein B-cell linker protein BLNK (PubMed:11606584).
BTK acts as a platform to bring together a diverse array of signaling proteins and is implicated in cytokine receptor signaling pathways.
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Related Signaling Pathways
BCR Signaling Pathway
Related Diseases
Primary Immunodeficiency
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0393 | Hi-Affi™ Rabbit Anti-BTK Recombinant Antibody (clone DS393AB) | ICC, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY267 | Anti-BTK Immunohistochemistry Kit | IHC | |
| VS-0525-XY854 | Anti-Mouse BTK Immunohistochemistry Kit | IHC | |
| VS-0525-XY853 | Anti-Human BTK Immunohistochemistry Kit | IHC |
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