Recombinant Anti-C1QTNF9 Eliminating Antibody, pH-Sensitive (XA272-917 var.)
CAT#: VS-0625-YC34
The anti-C1QTNF9 eliminating antibody is an engineered pH-sensitive antibody against human C1QTNF9. C1QTNF9 is associated with hormone activity, related to its paralog C1QTNF9B. The antibody has a novel C1QTNF9-sweeping activity in vivo, which selectively eliminatesthe soluble C1QTNF9 from plasma. Compared to conventional antibody, the mAb exerted in vivo efficacy by simultaneously engineering both pH-dependent antigen binding, to mimic the pH-dependent receptor-ligand binding of such endocytic receptors, and increased FcRn binding affinity at neutral pH, to mimic the cell-bound form of the receptors.
Gene Expression
Normal Tissue
Figure 1 IHC staining of human skeletal muscle
Immunohistochemical staining of human skeletal muscle shows strong cytoplasmic positivity in myocytes.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/56632/ihc_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Neuropil Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/56632/128754_B_8_5.jpg
Normal Tissue
Figure 3 Colon
Endothelial cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/56632/128754_A_9_3.jpg
Normal Tissue
Figure 4 Kidney
Cells in tubules Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/56632/128754_A_9_5.jpg
Normal Tissue
Figure 5 Testis
Cells in seminiferous ducts Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/56632/128754_A_5_6.jpg
Normal Tissue
Figure 6 Skeletal muscle
Myocytes Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/56632/128754_B_1_6.jpg
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Specifications
- Immunogen
- Recombinant human CTRP9A protein
- Host Species
- Mouse
- Type
- Mouse IgG
- Specificity
- Human C1QTNF9
- Species Reactivity
- Human
- Clone
- XA272-917 var.
- Applications
- Antigen-Sweeping In Vivo.
Product Property
- Purification
- Protein A/G purified
- Purity
- >95%
- Format
- Liquid
- Buffer
- PBS only
- Preservative
- None
- Storage
- Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- C1q And TNF Related 9; Complement C1q And Tumor Necrosis Factor-Related Protein 9; C1q And Tumor Necrosis Factor Related Protein 9; C1QTNF9A; Complement C1q And Tumor Necrosis Factor-Related Protein 9A; Complement C1q Tumor Necrosis Factor-Related Protein 9A; Complement C1q Tumor Necrosis Factor-Related Protein 9; CTRP9; AQL1;
- Gene ID
- 338872
- UniProt ID
- P0C862
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "C1QTNF9"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-M0011-YC | Mouse Anti-C1QTNF9 Recombinant Antibody (clone XA272-917) | ELISA | Mouse IgG |
| HPAB-M0012-YC | Mouse Anti-C1QTNF9 Recombinant Antibody (clone XA272-919) | ELISA | Mouse IgG |
| HPAB-M0013-YC | Mouse Anti-C1QTNF9 Recombinant Antibody (clone XA272-907) | ELISA | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-M0011-YC-S(P) | Mouse Anti-C1QTNF9 Recombinant Antibody (clone XA272-917); scFv Fragment | ELISA | Mouse scFv |
| HPAB-M0012-YC-S(P) | Mouse Anti-C1QTNF9 Recombinant Antibody (clone XA272-919); scFv Fragment | ELISA | Mouse scFv |
| HPAB-M0013-YC-S(P) | Mouse Anti-C1QTNF9 Recombinant Antibody (clone XA272-907); scFv Fragment | ELISA | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-M0011-YC-F(E) | Mouse Anti-C1QTNF9 Recombinant Antibody (clone XA272-917); Fab Fragment | ELISA | Mouse Fab |
| HPAB-M0012-YC-F(E) | Mouse Anti-C1QTNF9 Recombinant Antibody (clone XA272-919); Fab Fragment | ELISA | Mouse Fab |
| HPAB-M0013-YC-F(E) | Mouse Anti-C1QTNF9 Recombinant Antibody (clone XA272-907); Fab Fragment | ELISA | Mouse Fab |
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