Rabbit Anti-C4A Recombinant Antibody (clone R09-7F8)
CAT#: VS3-XY3283
The antibody is a recombinant rabbit antibody against C4A (Complement C4A), which is responsible for effective binding to form amide bonds with immune aggregates or protein antigens. It specifically reacts with human C4A. It has been detected by Western Blot, Immunocytochemistry or Immunofluorescence.
Gene Expression
Normal Tissue
Figure 1 Liver
Hepatocytes
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/50103/120024_A_8_4.jpg
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Specifications
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human C4A
- Species Reactivity
- Human
- Clone
- R09-7F8
- Applications
- WB, ICC, IF
- Related Disease
- Complement component 4A deficiency (C4AD); Systemic lupus erythematosus (SLE)
Product Property
- Clonality
- Monoclonal
- Aggregation
- < 5%
- Format
- Liquid
- Buffer
- PBS (pH 7.4), 150 mM NaCl and 50% glycerol
- Preservative
- 0.02% sodium azide
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- WB: 1/500-1/1000
IF: 1/50-1/200
Target
- Alternative Names
- C4; RG; C4S; CO4; C4A2; C4A3; C4A4; C4A6; C4AD; CPAMD2
- Gene ID
- 720
- UniProt ID
- P0C0L4
- Long Name
- Complement C4A
- Cellular Localization
- Cell projection, Secreted, Synapse
- Post Translation Modifications
- Prior to secretion, the single-chain precursor is enzymatically cleaved to yield non-identical chains alpha, beta and gamma. N- and O-glycosylated. O-glycosylated with a core 1 or possibly core 8 glycan.
- Protein Refseq
- NP_009224.2; NP_001239133.1
- Function
- Non-enzymatic component of C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. Covalently binds to immunoglobulins and immune complexes and enhances the solubilization of immune aggregates and the clearance of IC through CR1 on erythrocytes. C4A isotype is responsible for effective binding to form amide bonds with immune aggregates or protein antigens, while C4B isotype catalyzes the transacylation of the thioester carbonyl group to form ester bonds with carbohydrate antigens.
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Isotype Control
- CAT
- Product Name
Recommended Dilution Buffer
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "C4A"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1244z | Mouse Anti-C4A Recombinant Antibody (clone 39D3) | ELISA, ICC, IF, IHC | Mouse IgG1, κ |
| ZG-0303U | Rabbit Anti-C4A Recombinant Antibody (clone A24-T) | IHC-P | Rabbit IgG |
| VS3-WK620 | Rabbit Anti-C4A Recombinant Antibody (clone JM88-13) | WB, ELISA | Rabbit IgG |
| VS3-XY3284 | Rabbit Anti-C4A Recombinant Antibody (clone R05-1T2) | WB, IHC-P, FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0416 | Hi-Affi™ Rabbit Anti-C4A Recombinant Antibody (clone DS416AB) | IHC-P, IHC-Fr | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY883 | Anti-C4A Immunohistochemistry Kit | IHC | |
| VS-0525-XY884 | Anti-Human C4A Immunohistochemistry Kit | IHC |
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