Human Anti-C5 Recombinant Antibody Hexamer (VS-0924-YC103), CDC Enhanced
CAT#: VS-0924-YC103
The product is a human anti-C5 antibody designed as a hexamer to enhance CDC activity. This hexameric IgG1, which targets human C5, incorporates mutations that promote hexamer formation. These modifications optimize C1q binding, thereby enhancing complement-dependent cytotoxicity (CDC).
Gene Expression
RNA Expression
Figure 1 RNA cell line category: Cell line enhanced (A549, Hep G2)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000106804-C5
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Specifications
- Host Species
- Human
- Derivation
- Humanized
- Type
- Antibody hexamer
- Specificity
- Human C5
- Species Reactivity
- Human
- Molecule Class
- ~ 900 kDa
- Applications
- IB, CDC, Inhib
- Conjugate
- None
- Related Disease
- Complement-related disorders
Product Property
- Clonality
- Monoclonal
- Purification
- Protein A purified
- Purity
- >95% determined as SDS-PAGE and SEC-HPLC
- Aggregation
- <5%
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Store at 4°C short term (1-2 weeks). Store at -20°C long term (12 months). Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- C5; complement component 5; C5D; C5a; C5b; ECLZB; CPAMD4; complement C5; prepro-C5; C5a anaphylatoxin; anaphylatoxin C5a analog; C3 and PZP-like alpha-2-macroglobulin domain-containing protein
- Gene ID
- 727
- UniProt ID
- P01031
- Long Name
- Complement C5
- Cellular Localization
- Secreted
- Post Translation Modifications
- Glycosylation at Asn741, Asn911, Asn1115, and Asn1630 ( NX_P01031 [NX_P01031-1] )
- Protein Refseq
- NP_001304092.1; NP_001304093.1; NP_001726.2
- Function
- Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex.
C5b has a transient binding site for C6.
The C5b-C6 complex is the foundation upon which the lytic complex is assembled. CO5_HUMAN,P01031
[C5a anaphylatoxin]: Derived from proteolytic degradation of complement C5, C5a anaphylatoxin is a mediator of local inflammatory process.
Binding to the receptor C5AR1 induces a variety of responses including intracellular calcium release, contraction of smooth muscle, increased vascular permeability, and histamine release from mast cells and basophilic leukocytes (PubMed:8182049).
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Related Diseases
Systemic Lupus Erythematosus
Downloadable Resources
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Datasheet
MSDS
COA
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