Human Anti-C5 Recombinant Antibody Hexamer (VS-0924-YC103), CDC Enhanced (CAT#: VS-0924-YC103)

• Host Species
• Human

• Derivation
• Humanized

• Type
• Antibody hexamer

• Specificity
• Human C5

• Species Reactivity
• Human

• Molecule Class
• ~ 900 kDa

• Applications
• IB, CDC, Inhib

• Conjugate
• None

• Related Disease
• Complement-related disorders

• Clonality
• Monoclonal

• Purification
• Protein A purified

• Purity
• >95% determined as SDS-PAGE and SEC-HPLC

• Aggregation
• <5%

• Buffer
• PBS, pH 7.4

• Preservative
• No preservatives

• Storage
• Store at 4°C short term (1-2 weeks). Store at -20°C long term (12 months). Avoid repeated freeze/thaw cycles.

• Alternative Names
• C5; complement component 5; C5D; C5a; C5b; ECLZB; CPAMD4; complement C5; prepro-C5; C5a anaphylatoxin; anaphylatoxin C5a analog; C3 and PZP-like alpha-2-macroglobulin domain-containing protein

• Gene ID
• 727

• UniProt ID
• P01031

• Long Name
• Complement C5

• Cellular Localization
• Secreted

• Post Translation Modifications
• Glycosylation at Asn741, Asn911, Asn1115, and Asn1630 ( NX_P01031 [NX_P01031-1] )

• Protein Refseq
• NP_001304092.1; NP_001304093.1; NP_001726.2

• Function
• Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex.
  C5b has a transient binding site for C6.
  The C5b-C6 complex is the foundation upon which the lytic complex is assembled. CO5_HUMAN,P01031
  [C5a anaphylatoxin]: Derived from proteolytic degradation of complement C5, C5a anaphylatoxin is a mediator of local inflammatory process.
  Binding to the receptor C5AR1 induces a variety of responses including intracellular calcium release, contraction of smooth muscle, increased vascular permeability, and histamine release from mast cells and basophilic leukocytes (PubMed:8182049).

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