Human Anti-C9orf72 Recombinant Antibody (HPAB-0360-FY)
CAT#: HPAB-0360-FY
This product is a recombinant human antibody that recognizes C9orf72. The antibody was expressed in mammalian cells with chemically defined culture media and was purified by affinity chromatography.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line PC-3
Immunofluorescent staining of human cell line PC-3 shows localization to vesicles.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/23873/1034_E3_3_selected.jpg
Normal Tissue
Figure 2 IHC staining of human colon
Immunohistochemical staining of human colon shows strong cytoplasmic positivity in glandular cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/23873/ihc_selected.jpg
Normal Tissue
Figure 3 Colon
Glandular cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Peripheral nerve/ganglion
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/23873/51671_A_9_3.jpg
Normal Tissue
Figure 4 Kidney
Cells in glomeruli
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Cells in tubules
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/23873/51671_A_7_5.jpg
Normal Tissue
Figure 5 Testis
Cells in seminiferous ducts
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Leydig cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/23873/51671_A_4_6.jpg
Normal Tissue
Figure 6 Heart muscle
Cardiomyocytes
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/23873/51671_B_6_6.jpg
Normal Tissue
Figure 7 Lymph node
Non-germinal center cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/23873/51671_A_8_8.jpg
RNA Expression
Figure 8 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000147894-C9orf72
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Specifications
- Host Species
- Human
- Type
- Human IgG
- Specificity
- Human C9orf72
- Species Reactivity
- Human
- Applications
- Neut, FC, Block, FuncS, WB
- Related Disease
- Disorder; or symptoms related to DPRs
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- Dipeptide repeats; Dprs; ALSFTD; FTDALS; DENNL72; FTDALS1
- Gene ID
- 203228
REVIEWS AND Q&AS
CITATIONS
RESOURCES
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Effective Blocking Antibody
We used this recombinant human antibody in blocking assays to investigate the function of C9orf72. It interacts well with the protein involved in endosomal trafficking. The fact that it is expressed in mammalian cells with chemically defined media ensures a high-quality, contaminant-free product.
Validated For Western Blot
This antibody was reliable for detecting C9orf72 in our Western blot experiments. It helped us study the protein associated with ALS and FTD. The purity is over 95%, and it showed specific binding to the target human protein.
Q&As
-
What diseases are associated with the C9orf72 gene?
A: Expansion of GGGGCC repeats in the C9orf72 gene is associated with 9p-linked ALS (amyotrophic lateral sclerosis) and FTD (frontotemporal dementia).
-
What is the purity of this recombinant antibody?
A: The purity of this Human Anti-C9orf72 Recombinant Antibody is greater than 95% as determined by SDS-PAGE analysis.
View the frequently asked questions answered by Creative Biolabs Support.
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Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "C9orf72"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0359-FY | Human Anti-C9orf72 Recombinant Antibody (HPAB-0359-FY) | Neut, FC, Block, FuncS, WB | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0359-FY-S(P) | Human Anti-C9orf72 Recombinant Antibody; scFv Fragment (HPAB-0359-FY-S(P)) | WB, IP, ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0360-FY-S(P) | Human Anti-C9orf72 Recombinant Antibody; scFv Fragment (HPAB-0360-FY-S(P)) | WB, IP, ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0359-FY-F(E) | Human Anti-C9orf72 Recombinant Antibody; Fab Fragment (HPAB-0359-FY-F(E)) | WB, IP, ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0360-FY-F(E) | Human Anti-C9orf72 Recombinant Antibody; Fab Fragment (HPAB-0360-FY-F(E)) | WB, IP, ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS3-FY176 | Recombinant Mouse Anti-C9orf72 Antibody (clone 4D5G1) | ELISA, IHC, FC | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS3-FY177 | Recombinant Mouse Anti-C9orf72 Antibody (clone 6D6F12) | ELISA, WB, IHC, ICC, FC | Mouse IgG2b |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0224-FY23 | Rat Anti-C9orf72 Recombinant Antibody (VS-0224-FY23) | WB, IHC, ELISA, IF, ICC | Rat IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY286 | Anti-C9orf72 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY897 | Anti-Mouse C9orf72 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY896 | Anti-Human C9orf72 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY898 | Anti-Rat C9orf72 Immunohistochemistry Kit | IHC |
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