Rat Anti-C9orf72 Recombinant Antibody (VS-0224-FY23) (CAT#: VS-0224-FY23)
This is a rat monoclonal antibody that specifically designed for the detection of Guanine nucleotide exchange C9orf72. It is engineered to target an epitope located within 16 amino acids from the N-terminal half. The observed molecular weight of this antibody is approximately 54 kDa, while the calculated weight stands at 54.33 kDa. It recognizes hC9-S and hC9-L as well as mC9-1.
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Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line PC-3
(Immunofluorescent staining of human cell line PC-3 shows localization to vesicles.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/23873/1034_E3_3_selected.jpg
(Immunofluorescent staining of human cell line PC-3 shows localization to vesicles.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/23873/1034_E3_3_selected.jpg
Figure 2 IHC staining of human colon
(Immunohistochemical staining of human colon shows strong cytoplasmic positivity in glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/23873/ihc_selected.jpg
(Immunohistochemical staining of human colon shows strong cytoplasmic positivity in glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/23873/ihc_selected.jpg
Figure 3 Colon
(Glandular cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Peripheral nerve/ganglion
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/23873/51671_A_9_3.jpg
(Glandular cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Peripheral nerve/ganglion
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/23873/51671_A_9_3.jpg
Figure 4 Kidney
(Cells in glomeruli
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Cells in tubules
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/23873/51671_A_7_5.jpg
(Cells in glomeruli
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Cells in tubules
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/23873/51671_A_7_5.jpg
Figure 5 Testis
(Cells in seminiferous ducts
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Leydig cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/23873/51671_A_4_6.jpg
(Cells in seminiferous ducts
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Leydig cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/23873/51671_A_4_6.jpg
Figure 6 Heart muscle
(Cardiomyocytes
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/23873/51671_B_6_6.jpg
(Cardiomyocytes
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/23873/51671_B_6_6.jpg
Figure 7 Lymph node
(Non-germinal center cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/23873/51671_A_8_8.jpg
(Non-germinal center cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/23873/51671_A_8_8.jpg
Figure 8 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000147894-C9orf72
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000147894-C9orf72
Specifications
- Immunogen
- The 16 amino acids from the N-terminal half of human C9orf72.
- Host Species
- Rat
- Type
- Rat IgG1, κ
- Specificity
- Human and Mouse C9orf72
- Species Reactivity
- Human, Mouse
- Applications
- Western Blot, Immunohistochemistry, ELISA, Immunofluorescence, Immunocytochemistry
- Conjugate
- Unconjugated
- MW
- The observed molecular weight of this antibody is approximately 54 kDa, while the calculated weight stands at 54.33 kDa.
- Related Disease
- Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 1 and Amyotrophic Lateral Sclerosis 1
Product Property
- Purity
- >95%
- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl.
- Preservative
- 0.05% Sodium azide
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Western blot: 1/250
Target
- Alternative Names
- ALSFTD; DENND9; FTDALS; DENNL72; FTDALS1
- Gene ID
- 203228
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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IHC Kit and Antibody Products: Precision Tools for Immunohistochemistry
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0359-FY | Human Anti-C9orf72 Recombinant Antibody (HPAB-0359-FY) | Neut, FC, Block, FuncS, WB | Human IgG |
| HPAB-0360-FY | Human Anti-C9orf72 Recombinant Antibody (HPAB-0360-FY) | Neut, FC, Block, FuncS, WB | Human IgG |
| VS3-FY176 | Recombinant Mouse Anti-C9orf72 Antibody (clone 4D5G1) | ELISA, IHC, FC | Mouse IgG1 |
| VS3-FY177 | Recombinant Mouse Anti-C9orf72 Antibody (clone 6D6F12) | ELISA, WB, IHC, ICC, FC | Mouse IgG2b |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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