Anti-CA9 (clone M75) Recombinant Antibody Coupled Liposome (VS-1024-FY34)
CAT#: VS-1024-FY34
Anti-CA9 Antibody Liposome is a targeted therapeutic formulation designed for the delivery of therapeutic agents to cells expressing carbonic anhydrase IX (CA9), a protein commonly associated with hypoxic regions in tumors. This liposomal delivery system utilizes a high-affinity antibody that focuses on CA9, facilitating targeted therapy for cancer treatment.
Gene Expression
Normal Tissue
Figure 1 Immunofluorescent staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/5100/639_D5_2_selected.jpg
Normal Tissue
Figure 2 Stomach
Glandular cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/55207/139851_A_5_1.jpg
RNA Expression
Figure 3 RNA cell line category: Group enriched (A-431, HDLM-2, hTERT-RPE1, U-87 MG)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000107159-CA9
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More Infomation
Specifications
- Potential Clinical Applications
- Lung cancer
- Immunoliposomes Method
- Immunoliposomes were created using a modified post-insertion technique. DSPE-PEG-MAL micelles were formed by hydrating a lipid film in PBS, followed by thiolation of the anti-CA IX antibody using DTT. Unwanted reducing agents were removed through ethyl acetate extraction. Antibody-conjugated micelles were incubated with TPL-Lips to create CA IX-TPL-Lips, while unmodified micelles were used to form non-targeted TPL-Lips. Sepharose CL-4B gel filtration was utilized to eliminate unincorporated liposomes.
Product Composition
- Clone
- M75
- Antibody Type
- IgG1
- Antibody Host
- Mouse
- Antibody Reactivity
- Human
- Antibody Description
- This mouse monoclonal antibody specifically targets the human CA9 protein and can be utilized in various applications, including ELISA (dilution of 1:10,000), Western Blot (dilution range of 1:500 to 1:2000), and Flow Cytometry (dilution range of 1:200 to 1:400). The immunogen used to generate this antibody is a recombinant protein corresponding to amino acids 37-186 of the human CA9, which was expressed in E. coli.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- CA9
- Introduction
- Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid.
- Alternative Names
- MN; CAIX
- Full Name
- carbonic anhydrase 9
- Gene ID
- 768
- UniProt ID
- Q16790
- Sequence Similarities
- Belongs to the alpha-carbonic anhydrase family.
- Cellular Localization
- Nucleus
- Post Translation Modifications
- Asn-346 bears high-mannose type glycan structures. ( Q16790-CAH9_HUMAN )
Glycosylation at Thr115 and Asn346 ( NX_Q16790 [NX_Q16790-1] )
Modification sites at PhosphoSitePlus ( Q16790 )
Glycosylation from GlyGen (Q16790) 3 sites, 4 O-linked glycans (2 sites)
- Protein Refseq
- XP_047279805.1; XP_047279806.1; XP_054219735.1; XP_054219736.1; NP_001207.2
- Function
- Catalyzes the interconversion between carbon dioxide and water and the dissociated ions of carbonic acid (i.e.
bicarbonate and hydrogen ions).
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "Clone M75"
- CAT
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See other products for "CA9"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-707 | Anti-CAIX/CA9 Recombinant Antibody (Girentuximab) | WB, FuncS, IF, Neut, ELISA, FC, IP | IgG1 - kappa |
| TAB-H43 | Anti-Human CA9 Recombinant Antibody (TAB-H43) | ELISA, IP, IF, Inhib | IgG1 - kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBZ-017 | Mouse Anti-CA9 Recombinant Antibody (clone M75); Fab Fragment | WB, FuncS | Mouse IgG2b |
| HPAB-0104-LSX-F(E) | Human Anti-CA9 Recombinant Antibody; Fab Fragment (HPAB-0104-LSX-F(E)) | ELISA | Human Fab |
| HPAB-0105-LSX-F(E) | Human Anti-CA9 Recombinant Antibody; Fab Fragment (HPAB-0105-LSX-F(E)) | ELISA | Human Fab |
| HPAB-0782-CN-F(E) | Human Anti-CA9 Recombinant Antibody (clone G119); Fab Fragment | ELISA, FC | Human Fab |
| HPAB-0784-CN-F(E) | Human Anti-CA9 Recombinant Antibody (clone G37); Fab Fragment | ELISA, FC | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1456CL | Anti-Human CA9 Recombinant Antibody (MSC1) | ELISA, FC, Inhib | Fully human antibody |
| TAB-1457CL | Anti-Human CA9 Recombinant Antibody (MSC2) | ELISA, FC, Inhib | Fully human antibody |
| TAB-1459CL | Anti-Human CA9 Recombinant Antibody (MSC4) | ELISA, FC, Inhib | Fully human antibody |
| TAB-1460CL | Anti-Human CA9 Recombinant Antibody (MSC5) | ELISA, FC, Inhib | Fully human antibody |
| TAB-1461CL | Anti-Human CA9 Recombinant Antibody (MSC6) | ELISA, FC, Inhib | Fully human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1458CL-S(P) | Anti-Human CA9 Recombinant Antibody (MSC3); scFv Fragment | FC | Human scFv |
| HPAB-0782-CN-S(P) | Human Anti-CA9 Recombinant Antibody (clone G119); scFv Fragment | ELISA, FC | Human scFv |
| HPAB-0784-CN-S(P) | Human Anti-CA9 Recombinant Antibody (clone G37); scFv Fragment | ELISA, FC | Human scFv |
| HPAB-1174WJ-S(P) | Mouse Anti-CA9 Recombinant Antibody (clone AB-MN-21.5.2); scFv Fragment | ELISA | Mouse scFv |
| HPAB-1175WJ-S(P) | Mouse Anti-CA9 Recombinant Antibody (clone AB-MN-21.6.1); scFv Fragment | ELISA | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0427 | Hi-Affi™ Rabbit Anti-CA9 Recombinant Antibody (clone DS427AB) | IHC-P, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-0229-CN | Rabbit Anti-CA9 Recombinant Antibody (clone CBACN-083) | WB, IHC | Rabbit IgG |
| HPAB-1174WJ | Mouse Anti-CA9 Recombinant Antibody (clone AB-MN-21.5.2) | ADCC | Mouse IgG1 |
| HPAB-1175WJ | Mouse Anti-CA9 Recombinant Antibody (clone AB-MN-21.6.1) | ADCC | Mouse IgG1 |
| VS7-HM283 | Mouse Anti-CA9 Recombinant Antibody (clone 2D3) | WB, IHC, FCM | Mouse IgG1 |
| VS7-HM284 | Mouse Anti-CA9 Recombinant Antibody (clone CBL090HM) | WB, IHC-p, IF, FCM, ELISA | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-H43 | Afuco™ Anti-CA9 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-H43) | ELISA, FC, IP, FuncS, IF, Neut | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY37 | AbPlus™ Anti-CA9 Magnetic Beads (12F10) | IP, Protein Purification | |
| VS-0724-YC1029 | AbPlus™ Anti-CA9 Magnetic Beads (VS-0724-YC1029) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-FY54 | Human Anti-CA9 (clone G37) scFv-Fc Chimera | FC, ELISA, Inhib | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY290 | Anti-CA9 Immunohistochemistry Kit | IHC | |
| VS-0525-XY911 | Anti-Mouse CA9 Immunohistochemistry Kit | IHC | |
| VS-0525-XY912 | Anti-Human CA9 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC94 | Recombinant Anti-CA9 Vesicular Antibody, EV Displayed (VS-0425-YC94) | ELISA, FC, Neut, Cell-uptake |
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