Mouse Anti-CARD9 Recombinant Antibody (VS3-FY2646) (CAT#: VS3-FY2646)

• Host Species
• Mouse

• Type
• Mouse IgG

• Specificity
• Caspase recruitment domain family member 9 of human, mouse and rat origins

• Species Reactivity
• Human, Mouse, Rat

• Applications
• WB

• Conjugate
• Unconjugated, FITC

• MW
• The molecular weight of the target protein is approximately 62.2 kDa.

• Related Disease
• Immunodeficiency 103 Fungal Infections and Phaeohyphomycosis

• Clonality
• Monoclonal Antibody

• Format
• Liquid

• Concentration
• Please refer to the vial label for the specific concentration.

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.

• Application Notes
• Western Blot: 1/500-1/2000

• Alternative Names
• Caspase Recruitment Domain Family Member 9; HCARD9; Caspase Recruitment Domain-Containing Protein 9; Caspase Recruitment Domain Family, Member 9; CANDF2

• Gene ID
• 64170

• UniProt ID
• Q9H257

• Cellular Localization
• Cytoplasm

• Post Translation Modifications
• Phosphorylated at Thr-231 by PRKCD downstream of C-type lectin receptors activation: phosphorylation promotes interaction with BCL10, followed by activation of NF-kappa-B and MAP kinase p38 pathways (By similarity).
  Phosphorylated at Thr-531 and Thr-533 by CK2 following interaction with VHL, leading to inhibit the ability to activate NF-kappa-B (By similarity).
  Ubiquitinated at Lys-125 via 'Lys-27'-linked ubiquitin by TRIM62 downstream of C-type lectin receptors activation; leading to CARD9 activation, followed by activation of NF-kappa-B and MAP kinase p38 pathways.
  Deubiquitinated at Lys-125 by USP15, inhibiting CARD9.
  Ubiquitination at Lys125
  Modification sites at PhosphoSitePlus
  Glycosylation from GlyGen 2 sites, 1 O-linked glycan (2 sites)

• Protein Refseq
• NP_434700.2; NP_434701.1

• Function
• Upon activation, CARD9 homooligomerizes to form a nucleating helical template that recruits BCL10 via CARD-CARD interaction, thereby promoting polymerization of BCL10 and subsequent recruitment of MALT1: this leads to activation of NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines.

Secondary Antibody

• 2ND-040CQ
• Goat Anti-Mouse IgG (H&L) Antibody

Isotype Control

• MRO-A1591-YJ
• Mouse IgG Isotype control, Polyclonal

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