CytoStream™ Rabbit Anti-CASP10 Recombinant Antibody (VS13-YC124)
CAT#: VS13-YC124
The CytoStream™ Rabbit Anti-CASP10 Recombinant Antibody is specific for human CASP10. CASP10, a cysteine-aspartic protease family member, is key in apoptosis, associated with diseases like autoimmune lymphoproliferative syndrome, with multiple transcript and disease-linked variants. The anti-CASP10 antibody was developed and selected by our CytoStream™ platform and the mAb is recommended for use in flow cytometry staining (1/50-1/100).
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line Hep G2
Immunofluorescent staining of human cell line Hep G2 shows localization to the Golgi apparatus.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/17059/1404_C2_1_selected.jpg
Normal Tissue
Figure 2 Lymph node
Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/17059/40550_A_7_8.jpg
Normal Tissue
Figure 3 Colon
Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/17059/40550_A_7_3.jpg
Normal Tissue
Figure 4 Kidney
Cells in tubules Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/17059/40550_A_7_5.jpg
Normal Tissue
Figure 5 Testis
Cells in seminiferous ducts Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous Leydig cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/17059/40550_A_5_6.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enhanced (HUVEC TERT2)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000003400-CASP10
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Specifications
- Immunogen
- Recombinant human Caspase-10, aa 254-452.
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human CASP10
- Species Reactivity
- Human
- Applications
- WB, IHC-P, FC, IP
- Conjugate
- NONE
- Related Disease
- Autoimmune lymphoproliferative syndrome 2A (ALPS2A); Familial non-Hodgkin lymphoma (NHL); Gastric cancer (GASC)
Product Property
- Clonality
- Monoclonal
- Purification
- Protein A purified
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- TBS (pH 7.4) containing 40% Glycerol and 0.05% BSA.
- Preservative
- 0.05% Sodium azide
- Storage
- Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Shipping with ice pack.
Applications
- Application Notes
- Western blot (WB): 1/1000-1/2000
Flow cytometry (FC): 1/50-1/100
Immunohistochemistry-paraffin (IHC-P): 1/50-1/200
Target
- Alternative Names
- Caspase 10; FAS-Associated Death Domain Protein Interleukin-1B-Converting Enzyme 2; Caspase 10, Apoptosis-Related Cysteine Protease; ICE-Like Apoptotic Protease 4; CASP-10; FLICE2; MCH4; Caspase 10, Apoptosis-Related Cysteine Peptidase; Caspase 10 Apoptosis-Related Cysteine Peptidase;
- Gene ID
- 843
- UniProt ID
- Q92851
- Long Name
- Caspase 10
- Cellular Localization
- Cytosol
- Protein Refseq
- XP_005246964.1
- Function
- Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways. Cleaves and activates effector caspases CASP3, CASP4, CASP6, CASP7, CASP8 and CASP9.
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Related Signaling Pathways
TNF Signaling Pathway
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Secondary Antibody
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
See other products for "CASP10"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2489z | Mouse Anti-CASP10 Recombinant Antibody (clone 42G5) | WB, ELISA, IF, IP | Mouse IgM, κ |
| MOB-0324CT | Mouse Anti-CASP10 Recombinant Antibody (clone 3F8) | ELISA, WB | Mouse IgG2a |
| MRO-0238-CN | Rabbit Anti-CASP10 Recombinant Antibody (clone CBACN-087) | WB, IHC, IP, FC | Rabbit IgG |
| VS3-WK1089 | Rabbit Anti-CASP10 Recombinant Antibody (VS3-WK1089) | WB, IHC, IP, FC | Rabbit IgG |
| VS3-XY3288 | Rabbit Anti-CASP10 Recombinant Antibody (clone R03-3B2) | WB, IHC-P, ICC, IF, IP, FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0472 | Hi-Affi™ Rabbit Anti-CASP10 Recombinant Antibody (clone DS472AB) | FC, IF, IHC-P, IP, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY994 | Anti-CASP10 Immunohistochemistry Kit | IHC |
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