Mouse Anti-CBFA2T3 Recombinant Antibody (VS3-FY2648) (CAT#: VS3-FY2648)

• Host Species
• Mouse

• Type
• Mouse IgG

• Specificity
• CBFA2/RUNX1 translocation partner 3 of human and mouse origins

• Species Reactivity
• Human, Mouse

• Applications
• WB

• Conjugate
• Unconjugated, FITC

• MW
• The molecular weight of the target protein is approximately 71.2 kDa.

• Related Disease
• Acute Megakaryoblastic Leukemia Without Down Syndrome and Childhood Acute Megakaryoblastic Leukemia

• Clonality
• Monoclonal Antibody

• Format
• Liquid

• Concentration
• Please refer to the vial label for the specific concentration.

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.

• Application Notes
• Western Blot: 1/500-1/2000

• Alternative Names
• CBFA2/RUNX1 Translocation Partner 3; Core-Binding Factor, Runt Domain, Alpha Subunit 2; Translocated To, 3; Myeloid Translocation Gene On Chromosome 16 Protein; Zinc Finger MYND Domain-Containing Protein 4; Myeloid Translocation Gene 8 And 16b; MTG8-Related Protein 2; ZMYND4; MTG16

• Gene ID
• 863

• UniProt ID
• O75081

• Sequence Similarities
• Belongs to the CBFA2T family.

• Cellular Localization
• Nucleus

• Post Translation Modifications
• Modification sites at PhosphoSitePlus
  Modification sites at neXtProt

• Protein Refseq
• XP_005256380.1; XP_011521721.1; XP_047290782.1; XP_054170220.1; XP_054170221.1

• Function
• Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes (PubMed:12559562, 15203199).
  Can repress the expression of MMP7 in a ZBTB33-dependent manner (PubMed:23251453).
  Reduces the protein levels and stability of the transcriptinal regulator HIF1A; interacts with EGLN1 and promotes the HIF1A prolyl hydroxylation-dependent ubiquitination and proteasomal degradation pathway (PubMed:25974097).
  Contributes to inhibition of glycolysis and stimulation of mitochondrial respiration by down-regulating the expression of glycolytic genes including PFKFB3, PFKFB4, PDK1, PFKP, LDHA and HK1 which are direct targets of HIF1A (PubMed:23840896, 25974097).
  Regulates the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes (By similarity).
  Plays a role in granulocyte differentiation.

Secondary Antibody

• 2ND-040CQ
• Goat Anti-Mouse IgG (H&L) Antibody

Isotype Control

• MRO-A1591-YJ
• Mouse IgG Isotype control, Polyclonal

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