Mouse Anti-CBL Recombinant Antibody (CB367)
CAT#: VS-0326-YC367
The anti-CBL recombinant antibody (CB367) reacts with human, monkey, mouse, rat and rabbit CBL. CBL is an E3 ubiquitin ligase and adaptor protein that negatively regulates Receptor Tyrosine Kinase (RTK) signaling. It targets activated receptors, such as EGFR, for degradation. Mutations in CBL lead to sustained proliferative signaling and are frequently found in myeloid neoplasms. The anti-CBL antibody (CB367) has been tested in Enzyme-linked Immunosorbent Assay (ELISA), Immunocytochemistry (ICC), Immunohistochemistry (IHC), Western Blot (WB) and Flow Cytometry (FC).
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/27956/257_E11_2_selected.jpg
Normal Tissue
Figure 2 Lymph node
Non-germinal center cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/27956/61641_A_9_8.jpg
Normal Tissue
Figure 3 Tonsil
Germinal center cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Squamous epithelial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/27956/61641_A_4_8.jpg
Normal Tissue
Figure 4 Cerebral cortex
Endothelial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Glial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous nuclear Neuronal cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear Neuropil Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/27956/61641_B_8_5.jpg
Normal Tissue
Figure 5 Colon
Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/27956/61641_A_9_3.jpg
Normal Tissue
Figure 6 Kidney
Cells in glomeruli Staining: Medium Intensity: Moderate Quantity: 75%-25%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/27956/61641_A_7_5.jpg
Normal Tissue
Figure 7 Testis
Elongated or late spermatids Staining: Low Intensity: Weak Quantity: 75%-25% Pachytene spermatocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Preleptotene spermatocytes Staining: Low Intensity: Weak Quantity: 75%-25% Round or early spermatids Staining: Low Intensity: Weak Quantity: 75%-25% Spermatogonia cells Staining: High Intensity: Strong
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/27956/61641_A_4_6.jpg
RNA Expression
Figure 8 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000110395-CBL
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Specifications
- Host Species
- Mouse
- Type
- Mouse IgG1
- Specificity
- Human, Monkey, Mouse, Rat and Rabbit CBL
- Species Reactivity
- Human, Monkey, Mouse, Rat, Rabbit
- Clone
- CB367
- Applications
- ELISA, ICC, IHC, WB, FC
- Conjugate
- The unconjugated, Biotin and FITC formats are available.
Product Property
- Clonality
- Monoclonal
- Purification
- Affinity purified
- Format
- Liquid
- Buffer
- PBS
- Preservative
- 0.05% Sodium azide
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Applications
- Application Notes
- WB (1/500-1/2000), IHC (1/100-1/500), ICC (1/50-1/500), ELISA (1/5000-1/20000), FC (1/200-1/400)
Target
- Alternative Names
- Cbl Proto-Oncogene; Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence; Cbl Proto-Oncogene, E3 Ubiquitin Protein Ligase; Casitas B-Lineage Lymphoma Proto-Oncogene; RING-Type E3 Ubiquitin Transferase CBL; Signal Transduction Protein CBL; RING Finger Protein 55; Proto-Oncogene C-Cbl; Oncogene CBL2; RNF55;
- Gene ID
- 867
- UniProt ID
- P22681
- Long Name
- Cbl Proto-Oncogene
- Post Translation Modifications
- Unmodified
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Secondary Antibody
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
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|---|---|---|---|
| MOB-2089z | Mouse Anti-CBL Recombinant Antibody (clone 34A6) | WB, ELISA, ICC, IF, IHC | Mouse IgG |
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| FAMAB-0161-CN | Mouse Anti-CBL Recombinant Antibody (clone CBLNC-104) | WB, ELISA | Mouse IgG |
| CAT | Product Name | Application | Type |
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| FAMAB-0273-CN | Mouse Anti-CBL Recombinant Antibody (clone 5D1) | WB, ELISA | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0161-CN-S(P) | Mouse Anti-CBL Recombinant Antibody (clone CBLNC-104); scFv Fragment | WB, ELISA | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0273-CN-S(P) | Mouse Anti-CBL Recombinant Antibody (clone 5D1); scFv Fragment | WB, ELISA | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0287-CN-S(P) | Human Anti-CBL Recombinant Antibody (clone CLB-1); scFv Fragment | ELISA | Human scFv |
| CAT | Product Name | Application | Type |
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| FAMAB-0161-CN-F(E) | Mouse Anti-CBL Recombinant Antibody (clone CBLNC-104); Fab Fragment | WB, ELISA | Mouse Fab |
| CAT | Product Name | Application | Type |
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| FAMAB-0273-CN-F(E) | Mouse Anti-CBL Recombinant Antibody (clone 5D1); Fab Fragment | WB, ELISA | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0287-CN-F(E) | Human Anti-CBL Recombinant Antibody (clone CLB-1); Fab Fragment | ELISA | Human Fab |
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| CAT | Product Name | Application | Type |
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| VS-0525-XY1031 | Anti-Human CBL Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| VS-0126-XL893 | Rabbit Anti-Cbl (phospho Y774) Antibody | Phospho Antibodies for Cell Signaling Research |
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