Human Anti-CBX5 Recombinant Antibody (clone RAB-C133) (CAT#: VS11-QX17)

• Immunogen
• CBX5 protein

• Host Species
• Human

• Derivation
• Human

• Type
• Human IgG1, κ

• Specificity
• Human CBX5

• Species Reactivity
• Human

• Clone
• RAB-C133

• Applications
• ELISA, IP-MS, ChIP

• Conjugate
• Unconjugated

• Clonality
• Monoclonal

• Purification
• Protein A purified

• Purity
• >95% as determined by SDS-PAGE

• Concentration
• 1 mg/mL (Please refer to the vial label for the specific concentration.)

• Buffer
• 0.2 μm filtered solution in PBS

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Shipping
• Shipped at 4°C.

• Alternative Names
• Chromobox 5; Chromobox Homolog 5 (HP1 Alpha Homolog, Drosophila); Heterochromatin Protein 1 Homolog Alpha; Antigen P25; HP1A; Chromobox Homolog 5 (Drosophila HP1 Alpha); Heterochromatin Protein 1-Alpha; HP1 Alpha Homolog (Drosophila); Epididymis Luminal Protein 25

• Gene ID
• 23468

• UniProt ID
• P45973

• Long Name
• Chromobox protein homolog 5

• Cellular Localization
• Nucleoplasm

• Function
• Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.

Isotype Control

• MOB-0402ZL
• Human IgG1, kappa - Isotype Control Antibody

Recommended Dilution Buffer

• MRO-0253YJ
• Reconstitution Buffer PBS

Secondary Antibody

• 2ND-024CQ
• Goat Anti-Human IgG (H&L) Antibody

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