Anti-CCNA2 (clone W24V165) Recombinant Antibody Coupled Liposome (VS-1024-FY166)
CAT#: VS-1024-FY166
This innovative antibody-conjugated liposome system specifically targets the cell cycle regulator CCNA2, allowing for more effective and localized delivery of therapeutic agents directly to melanoma cells. By focusing on this critical regulator, the treatment not only enhances the therapeutic efficacy but also minimizes the adverse side effects commonly associated with systemic drug administration. Recent research suggests that this targeted approach holds significant promise in inhibiting tumor growth, potentially leading to improved outcomes for patients suffering from melanoma.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm & cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/114/667_H11_1_selected.jpg
Normal Tissue
Figure 2 Tonsil
High expression
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/114/162272_A_6_8_selected.jpg
Normal Tissue
Figure 3 Colon
Endocrine cells Staining: High Intensity: Strong Enterocytes Staining: Medium Intensity: Strong Quantity: <25% Enterocytes - Goblet cells Staining: Medium Intensity: Strong Quantity: <25%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/114/162272_A_7_3.jpg
Normal Tissue
Figure 4 Kidney
Cells in tubules Staining: Low Intensity: Moderate Quantity: <25% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/114/162272_A_7_5.jpg
Normal Tissue
Figure 5 Lymph node
Germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: nuclear Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/114/162272_A_9_8.jpg
RNA Expression
Figure 6 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000145386-CCNA2
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More Infomation
Specifications
- Potential Clinical Applications
- Melanoma
Product Composition
- Clone
- W24V165
- Antibody Type
- IgG
- Antibody Host
- Mouse
- Antibody Reactivity
- Human
- Antibody Description
- This is a recombinant monoclonal antibody derived from mouse cells, specifically engineered to bind to the cyclin A2 protein, known as CCNA2. Cyclin A2 is a crucial regulatory protein involved in cell cycle control, particularly during the transitions between different phases of cell division.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- CCNA2
- Introduction
- CCNA2 (Cyclin A2) is a Protein Coding gene. Diseases associated with CCNA2 include Splenic Diffuse Red Pulp Small B-Cell Lymphoma and Valproate Embryopathy. Among its related pathways are CDK-mediated phosphorylation and removal of Cdc6 and Signaling events mediated by PRL. Gene Ontology (GO) annotations related to this gene include protein kinase binding. An important paralog of this gene is CCNA1.
- Alternative Names
- Cyclin A2; Cyclin-A; CCN1; CCNA; Cyclin-A2; Cyclin A
- Full Name
- Cyclin A2
- Gene ID
- 890
- UniProt ID
- P20248
- Sequence Similarities
- Belongs to the cyclin family. Cyclin AB subfamily.
- Cellular Localization
- Cytoplasm, Nucleus
- Post Translation Modifications
- Polyubiquitinated via 'Lys-11'-linked ubiquitin by the anaphase-promoting complex (APC/C), leading to its degradation by the proteasome. Deubiquitinated and stabilized by USP37 enables entry into S phase.
- Protein Refseq
- NP_001228.1
- Function
- Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine protein kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 or CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle.
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Datasheet
MSDS
COA
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See other products for "CCNA2"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2072MZ | Mouse Anti-CCNA2 Recombinant Antibody (clone 3223D3b) | WB | Mouse IgG1 |
| MRO-1797-CN | Rabbit Anti-CCNA2 Polyclonal Antibody (MRO-1797-CN) | WB, IHC | Rabbit IgG |
| VS3-QX172 | Mouse Anti-CCNA2 Recombinant Antibody (clone 1G1-C7-F9) | WB, IHC, ICC, FC, ELISA | |
| VS3-XY179 | Mouse Anti-CCNA2 Recombinant Antibody (clone 1A8H2C12) | ELISA, WB, IHC, FC | |
| VS13-YC146 | Rabbit Anti-CCNA2 Recombinant Antibody (VS13-YC146) | WB, ICC, IF, IHC-P | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0513 | Hi-Affi™ Rabbit Anti-CCNA2 Recombinant Antibody (clone DS513AB) | IF, IP, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC4366 | PE-B*40:01/Human CCNA2 (YHEDIHTYL) MHC Tetramer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-YC1313 | AbPlus™ Anti-Ccna2 Magnetic Beads (VS-0724-YC1313) | IP, Protein Purification | |
| VS-0724-YC1370 | AbPlus™ Anti-CCNA2 Magnetic Beads (VS-0724-YC1370) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1024-XY145 | Mouse Anti-NHP CCNA2 Recombinant Antibody (clone E23.1) | WB, IHC, IF, IP | Mouse IgG2a |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY333 | Anti-CCNA2 Immunohistochemistry Kit | IHC | |
| VS-0525-XY1079 | Anti-Mouse CCNA2 Immunohistochemistry Kit | IHC | |
| VS-0525-XY1078 | Anti-Human CCNA2 Immunohistochemistry Kit | IHC |
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