Anti-CCNA2 (clone W24V165) Recombinant Antibody Coupled Liposome (VS-1024-FY166) (CAT#: VS-1024-FY166)
This innovative antibody-conjugated liposome system specifically targets the cell cycle regulator CCNA2, allowing for more effective and localized delivery of therapeutic agents directly to melanoma cells. By focusing on this critical regulator, the treatment not only enhances the therapeutic efficacy but also minimizes the adverse side effects commonly associated with systemic drug administration. Recent research suggests that this targeted approach holds significant promise in inhibiting tumor growth, potentially leading to improved outcomes for patients suffering from melanoma.
More Infomation
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm & cytosol.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/114/667_H11_1_selected.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm & cytosol.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/114/667_H11_1_selected.jpg
Figure 2 Tonsil
(High expression)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/114/162272_A_6_8_selected.jpg
(High expression)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/114/162272_A_6_8_selected.jpg
Figure 3 Colon
(Endocrine cells Staining: High Intensity: Strong Enterocytes Staining: Medium Intensity: Strong Quantity: <25% Enterocytes - Goblet cells Staining: Medium Intensity: Strong Quantity: <25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/114/162272_A_7_3.jpg
(Endocrine cells Staining: High Intensity: Strong Enterocytes Staining: Medium Intensity: Strong Quantity: <25% Enterocytes - Goblet cells Staining: Medium Intensity: Strong Quantity: <25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/114/162272_A_7_3.jpg
Figure 4 Kidney
(Cells in tubules Staining: Low Intensity: Moderate Quantity: <25% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/114/162272_A_7_5.jpg
(Cells in tubules Staining: Low Intensity: Moderate Quantity: <25% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/114/162272_A_7_5.jpg
Figure 5 Lymph node
(Germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: nuclear Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/114/162272_A_9_8.jpg
(Germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: nuclear Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/114/162272_A_9_8.jpg
Figure 6 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000145386-CCNA2
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000145386-CCNA2
Specifications
- Potential Clinical Applications
- Melanoma
Product Composition
- Clone
- W24V165
- Antibody Type
- IgG
- Antibody Host
- Mouse
- Antibody Reactivity
- Human
- Antibody Description
- This is a recombinant monoclonal antibody derived from mouse cells, specifically engineered to bind to the cyclin A2 protein, known as CCNA2. Cyclin A2 is a crucial regulatory protein involved in cell cycle control, particularly during the transitions between different phases of cell division.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- CCNA2
- Introduction
- CCNA2 (Cyclin A2) is a Protein Coding gene. Diseases associated with CCNA2 include Splenic Diffuse Red Pulp Small B-Cell Lymphoma and Valproate Embryopathy. Among its related pathways are CDK-mediated phosphorylation and removal of Cdc6 and Signaling events mediated by PRL. Gene Ontology (GO) annotations related to this gene include protein kinase binding. An important paralog of this gene is CCNA1.
- Alternative Names
- Cyclin A2; Cyclin-A; CCN1; CCNA; Cyclin-A2; Cyclin A
- Full Name
- Cyclin A2
- Gene ID
- 890
- UniProt ID
- P20248
- Sequence Similarities
- Belongs to the cyclin family. Cyclin AB subfamily.
- Cellular Localization
- Cytoplasm, Nucleus
- Post Translation Modifications
- Polyubiquitinated via 'Lys-11'-linked ubiquitin by the anaphase-promoting complex (APC/C), leading to its degradation by the proteasome. Deubiquitinated and stabilized by USP37 enables entry into S phase.
- Protein Refseq
- NP_001228.1
- Function
- Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine protein kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 or CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "CCNA2"
Select a product category from the dropdown menu below to view related products.
Please select product type
IgG Antibody Products
Rabbit Monoclonal Antibody Products
MHC Tetramer Products for Cancer
Antibody Magnetic Beads
Non-Human Primate (NHP) Antibody Products
IHC Kit and Antibody Products: Precision Tools for Immunohistochemistry
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2072MZ | Mouse Anti-CCNA2 Recombinant Antibody (clone 3223D3b) | WB | Mouse IgG1 |
| MRO-0408-CN | Mouse Anti-CCNA2 Recombinant Antibody (clone N0-E3) | WB, IF, IHC | Mouse IgG1 |
| MRO-0409-CN | Rabbit Anti-CCNA2 Recombinant Antibody (clone CBACN-161) | WB, IF, IHC | Rabbit IgG |
| VS3-FY210 | Recombinant Rabbit Anti-CCNA2 Antibody (clone R02-3H6) | WB, IHC-F, IHC-P, ICC, IF, IP | Rabbit IgG |
| VS3-FY211 | Recombinant Rabbit Anti-CCNA2 Antibody (clone R02-9B6) | WB, IHC-F, IHC-P, ICC, IF, IP | Rabbit IgG |
Customer Reviews and Q&As
There are currently no Customer reviews or questions for VS-1024-FY166. Click the button above to contact us or submit your feedback about this product.
Popular products with customers
Application: ELISA, IP, FC, FuncS, Neut, IF, ICC
Application: IP, IF, FuncS, FC, Neut, ELISA, ICC
Application: Neut, ELISA, IF, IP, FuncS, FC, ICC
Application: FC, IP, ELISA, Neut, FuncS, IF, ICC
Application: WB, ELISA, FuncS
-1.jpg)
Application: WB, ELISA, IF, FuncS, Apop, BA
Application: ELISA, IHC, FC, IP, IF, FuncS
Application: ELISA
Application: ELISA, IHC, IF, IP
Application: ELISA, Vaccine, FuncS
For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
