Anti-CCNA2 (clone W24V165) Recombinant Antibody Coupled Liposome (VS-1024-FY166) (CAT#: VS-1024-FY166)

• Potential Clinical Applications
• Melanoma

• Clone
• W24V165

• Antibody Type
• IgG

• Antibody Host
• Mouse

• Antibody Reactivity
• Human

• Antibody Description
• This is a recombinant monoclonal antibody derived from mouse cells, specifically engineered to bind to the cyclin A2 protein, known as CCNA2. Cyclin A2 is a crucial regulatory protein involved in cell cycle control, particularly during the transitions between different phases of cell division.

• Storage
• See in the COA

• Storage Shelf Time
• See in the COA

• Target
• CCNA2

• Introduction
• CCNA2 (Cyclin A2) is a Protein Coding gene. Diseases associated with CCNA2 include Splenic Diffuse Red Pulp Small B-Cell Lymphoma and Valproate Embryopathy. Among its related pathways are CDK-mediated phosphorylation and removal of Cdc6 and Signaling events mediated by PRL. Gene Ontology (GO) annotations related to this gene include protein kinase binding. An important paralog of this gene is CCNA1.

• Alternative Names
• Cyclin A2; Cyclin-A; CCN1; CCNA; Cyclin-A2; Cyclin A

• Full Name
• Cyclin A2

• Gene ID
• 890

• UniProt ID
• P20248

• Sequence Similarities
• Belongs to the cyclin family. Cyclin AB subfamily.

• Cellular Localization
• Cytoplasm, Nucleus

• Post Translation Modifications
• Polyubiquitinated via 'Lys-11'-linked ubiquitin by the anaphase-promoting complex (APC/C), leading to its degradation by the proteasome. Deubiquitinated and stabilized by USP37 enables entry into S phase.

• Protein Refseq
• NP_001228.1

• Function
• Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine protein kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 or CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle.

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