Rabbit Anti-CCR2 Recombinant Antibody (VS3-CJ941)
CAT#: VS3-CJ941
This product is a rabbit antibody that recognizes human, mouse, and rat CCR2.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line THP-1
Immunofluorescent staining of human cell line THP-1 shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/63255/1926_C6_4_selected.jpg
Normal Tissue
Figure 2 IHC staining of human cervix, uterine
Immunohistochemical staining of human cervix, uterine shows strong cytoplasmic positivity in squamous epithelial cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/3793/ihc_selected.jpg
Normal Tissue
Figure 3 Cervix
Squamous epithelial cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/3793/10521_B_8_3.jpg
Normal Tissue
Figure 4 Lymph node
Germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/3793/10521_A_9_8.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enhanced (Karpas-707, THP-1, U-266/70, U-266/84)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000121807-CCR2
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Specifications
- Immunogen
- Recombinant protein
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human, Mouse, Rat CCR2
- Species Reactivity
- Human, Mouse, Rat
- Applications
- WB, IHC, IP, FC
- Conjugate
- Unconjugated
Product Property
- Purification
- Protein A affinity purified
- Purity
- >95% as determined by SDS-PAGE
- Format
- Liquid
- Buffer
- 40% Glycerol, 1% BSA, TBS, pH7.4.
- Preservative
- 0.05% Sodium Azide
- Storage
- Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- This antibody has been tested for use in Western Blot, Immunohistochemistry, Immunoprecipitation, Flow Cytometry.
Target
- Alternative Names
- CKR2; CCR-2; CCR2A; CCR2B; CD192; CKR2A; CKR2B; CMKBR2; MCP-1-R; CC-CKR-2
- Gene ID
- 729230
- UniProt ID
- P41597
- Sequence Similarities
- Belongs to the G-protein coupled receptor 1 family.
- Cellular Localization
- Cell membrane, Membrane
- Post Translation Modifications
- N-glycosylated.
Sulfation increases the affinity for both monomeric and dimeric CCL2 with stronger binding to the monomeric form (PubMed:11046064, PubMed:23408426).
Binding of sulfated CCR2 to CCL2 promotes conversion of CCL2 from dimer to monomer (PubMed:11046064, PubMed:23408426).
- Protein Refseq
- NP_001116513.2; NP_001116868.1
- Function
- Key functional receptor for CCL2 but can also bind CCL7 and CCL12 (PubMed:8146186, PubMed:8048929, PubMed:23408426).
Its binding with CCL2 on monocytes and macrophages mediates chemotaxis and migration induction through the activation of the PI3K cascade, the small G protein Rac and lamellipodium protrusion (Probable). Also acts as a receptor for the beta-defensin DEFB106A/DEFB106B (PubMed:23938203).
Regulates the expression of T-cell inflammatory cytokines and T-cell differentiation, promoting the differentiation of T-cells into T-helper 17 cells (Th17) during inflammation (By similarity).
Facilitates the export of mature thymocytes by enhancing directional movement of thymocytes to sphingosine-1-phosphate stimulation and up-regulation of S1P1R expression; signals through the JAK-STAT pathway to regulate FOXO1 activity leading to an increased expression of S1P1R (By similarity).
Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity).
Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-dependent phosphorylation of GRIN2B/NMDAR2B (By similarity).
Mediates the recruitment of macrophages and monocytes to the injury site following brain injury (By similarity).
(Microbial infection) Alternative coreceptor with CD4 for HIV-1 infection.
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1508CL | Human Anti-CCR2 Recombinant Antibody (TAB-1508CL) | FuncS | Human IgG |
| TAB-1509CL | Human Anti-CCR2 Recombinant Antibody (TAB-1509CL) | FC | Human IgG |
| TAB-1510CL | Human Anti-CCR2 Recombinant Antibody (TAB-1510CL) | FC | Human IgG |
| TAB-1511CL | Human Anti-CCR2 Recombinant Antibody (TAB-1511CL) | ELISA | Human IgG |
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|---|---|---|---|
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| HPAB-0247-YC-F(E) | Human Anti-CCR2 Recombinant Antibody; Fab Fragment (HPAB-0247-YC-F(E)) | ELISA, FC | Human Fab |
| HPAB-0248-YC-F(E) | Human Anti-CCR2 Recombinant Antibody; Fab Fragment (HPAB-0248-YC-F(E)) | ELISA, FC | Human Fab |
| HPAB-0249-YC-F(E) | Human Anti-CCR2 Recombinant Antibody; Fab Fragment (HPAB-0249-YC-F(E)) | ELISA, FC | Human Fab |
| HPAB-0250-YC-F(E) | Human Anti-CCR2 Recombinant Antibody; Fab Fragment (HPAB-0250-YC-F(E)) | ELISA, FC | Human Fab |
| HPAB-0251-YC-F(E) | Mouse Anti-CCR2 Recombinant Antibody (clone 1D9); Fab Fragment | Antagonist | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-444CQ | Afuco™ Anti-CCR2 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-444CQ) | ELISA, IHC, FC, IP, IF, Inhib | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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