Human Anti-CCR4 Recombinant Antibody (clone 11F) (CAT#: HPAB-1007WJ)
This product is a human antibody binds to an epitope in the extracellular domain of human CC chemokine receptor 4 (CCR4) and which are capable of inhibiting the binding of macrophage-derived chemokine (MDC) and/or thymus and activation regulated chemokine (TARC) to CCR4.
Specific Inquiry
FC
Figure 1 Binding of anti-CCR4 scFv fragments to avian DT40 cells transfected with human CCR4.
The results of titration on DT40/CCR4 and non-transfected DT40 cells are shown for scFv 17G (a), 9E (b), 1O (c) and 11F (d). Binding of scFv fragments in the presence of increasing concentrations of CCR4 ligands CCL22 and CCL17 is shown in panels (e) and (f), respectively. As a control, a scFv fragment derived from hybridoma KM2160 was used. Cell binding was analyzed by flow cytometry; bound scFv fragments were detected with anti-cMyc antibody followed by anti-human-PE immunoconjugates. Median fluorescence intensity is plotted against the scFv concentration (µg/mL); the results of representative experiments from three repeats are shown.
Hagemann, U. B., Gunnarsson, L., Géraudie, S., Scheffler, U., Griep, R. A., Reiersen, H., ... & Kiprijanov, S. M. (2014). Fully human antagonistic antibodies against CCR4 potently inhibit cell signaling and chemotaxis. PLoS One, 9(7), e103776.
Specifications
- Host Species
- Human
- Type
- Human IgG1, κ
- Specificity
- Human CCR4
- Species Reactivity
- Human
- Clone
- 11F
- Applications
- FC, ELISA, WB
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- The CCR4 antibody has been reported in applications of Flow Cytometry, Enzyme-linked Immunosorbent Assay, Western Blot.
Target
- Alternative Names
- C-C Motif Chemokine Receptor 4; Chemokine (C-C Motif) Receptor 4; C-C CKR-4; CC-CKR-4; CMKBR4; CCR-4; K5-5; C-C Chemokine Receptor Type 4;
- Gene ID
- 1233
- UniProt ID
- P51679
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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See other products for "Clone 11F"
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Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-187 | Human Anti-CCR4 Recombinant Antibody (TAB-187) | Neut, ELISA, IF, IP, FuncS, FC, ICC | Human IgG1, κ |
| TAB-1530CL | Human Anti-CCR4 Recombinant Antibody (TAB-1530CL) | Depletion, FuncS | Human IgG4 |
| TAB-1530CL-S(P) | Human Anti-CCR4 Recombinant Antibody; scFv Fragment (TAB-1530CL-S(P)) | Depletion, FuncS | Human scFv |
| TAB-1530CL-F(E) | Human Anti-CCR4 Recombinant Antibody; Fab Fragment (TAB-1530CL-F(E)) | Depletion, FuncS | Humanized Fab |
Immunotoxin
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AGTO-G005D | Anti-CCR4 immunotoxin (scFv)-DT | Cytotoxicity assay, Function study |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1527CL | Anti-Human CCR4 Recombinant Antibody (601) | FC, Inhib | Human antibody |
| TAB-1528CL | Anti-Human CCR4 Recombinant Antibody (603) | FC, Inhib | Human antibody |
| TAB-1529CL | Anti-Human CCR4 Recombinant Antibody (803) | FC, Inhib | Human antibody |
| TAB-1521CL-F(E) | Anti-Human CCR4 Recombinant Antibody Fab Fragment (208) | FC, Inhib | Human antibody |
| TAB-1522CL-F(E) | Anti-Human CCR4 Recombinant Antibody Fab Fragment (306) | FC, Inhib | Human antibody |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0141-LSX | Mouse Anti-CCR4 Recombinant Antibody (HPAB-0141-LSX) | ELISA, WB, FC, ADCC, CDC, FuncS | Mouse IgG2b |
| HPAB-0143-LSX | Human Anti-CCR4 Recombinant Antibody (HPAB-0143-LSX) | ELISA, WB, FC, ADCC, CDC, FuncS | Human IgG |
| HPAB-0144-LSX | Human Anti-CCR4 Recombinant Antibody (HPAB-0144-LSX) | ELISA, WB, FC, ADCC, CDC | Human IgG |
| HPAB-0145-LSX | Human Anti-CCR4 Recombinant Antibody (HPAB-0145-LSX) | ELISA, WB, FC, ADCC, CDC | Human IgG |
| HPAB-1109WJ | Human Anti-CCR4 Recombinant Antibody (HPAB-1109WJ) | ELISA, FC | Humanized IgG1 |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0047-FY-S(P) | Human Anti-CCR4 Recombinant Antibody; scFv Fragment (HPAB-0047-FY-S(P)) | FC | Human scFv |
| HPAB-1109WJ-S(P) | Human Anti-CCR4 Recombinant Antibody; scFv Fragment (HPAB-1109WJ-S(P)) | FC | Humanized scFv |
| HPAB-1268WJ-S(P) | Mouse Anti-CCR4 Recombinant Antibody; scFv Fragment (HPAB-1268WJ-S(P)) | ELISA, WB, FC | Mouse scFv |
| MOB-213YJL-S(P) | Mouse Anti-CCR4 Recombinant Antibody (clone chKM2760); scFv Fragment | ELISA, FC, FuncS | Mouse scFv |
| HPAB-1370WJ-S(P) | Human Anti-CCR4 Recombinant Antibody; scFv Fragment (clone KM2760) | ELISA, WB | Human scFv |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0047-FY-F(E) | Human Anti-CCR4 Recombinant Antibody; Fab Fragment (HPAB-0047-FY-F(E)) | FC | Human Fab |
| HPAB-1004WJ-F(E) | Human Anti-CCR4 Recombinant Antibody (clone 17G); Fab Fragment | ELISA, WB | Human Fab |
| HPAB-1005WJ-F(E) | Human Anti-CCR4 Recombinant Antibody (clone 9E); Fab Fragment | ELISA, WB | Human Fab |
| HPAB-1006WJ-F(E) | Human Anti-CCR4 Recombinant Antibody (clone 1O); Fab Fragment | ELISA, WB | Human Fab |
| HPAB-1007WJ-F(E) | Human Anti-CCR4 Recombinant Antibody (clone 11F); Fab Fragment | ELISA, WB | Human Fab |
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-187 | Afuco™ Anti-CCR4 Recombinant Antibody (AFC-TAB-187), ADCC Enhanced | Neut, ELISA, IF, IP, FuncS, FC | Human IgG1, κ |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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