Human Anti-CCR4 Recombinant Antibody (clone 1O) (CAT#: HPAB-1006WJ)
This product is a human antibody binds to an epitope in the extracellular domain of human CC chemokine receptor 4 (CCR4) and which are capable of inhibiting the binding of macrophage-derived chemokine (MDC) and/or thymus and activation regulated chemokine (TARC) to CCR4.
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We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.
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FC
Figure 1 Binding of anti-CCR4 scFv fragments to avian DT40 cells transfected with human CCR4.
The results of titration on DT40/CCR4 and non-transfected DT40 cells are shown for scFv 17G (a), 9E (b), 1O (c) and 11F (d). Binding of scFv fragments in the presence of increasing concentrations of CCR4 ligands CCL22 and CCL17 is shown in panels (e) and (f), respectively. As a control, a scFv fragment derived from hybridoma KM2160 was used. Cell binding was analyzed by flow cytometry; bound scFv fragments were detected with anti-cMyc antibody followed by anti-human-PE immunoconjugates. Median fluorescence intensity is plotted against the scFv concentration (µg/mL); the results of representative experiments from three repeats are shown.
Hagemann, U. B., Gunnarsson, L., Géraudie, S., Scheffler, U., Griep, R. A., Reiersen, H., ... & Kiprijanov, S. M. (2014). Fully human antagonistic antibodies against CCR4 potently inhibit cell signaling and chemotaxis. PLoS One, 9(7), e103776.
Specifications
- Host Species
- Human
- Type
- Human IgG1, λ
- Specificity
- Human CCR4
- Species Reactivity
- Human
- Clone
- 1O
- Applications
- FC, ELISA, WB
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- The CCR4 antibody has been reported in applications of Flow Cytometry, Enzyme-linked Immunosorbent Assay, Western Blot.
Target
- Alternative Names
- C-C Motif Chemokine Receptor 4; Chemokine (C-C Motif) Receptor 4; C-C CKR-4; CC-CKR-4; CMKBR4; CCR-4; K5-5; C-C Chemokine Receptor Type 4;
- Gene ID
- 1233
- UniProt ID
- P51679
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1992z | Mouse Anti-CCR4 Recombinant Antibody (clone 42C4) | WB, FC, ICC, IF | Mouse IgG2a |
| HPAB-0141-LSX | Mouse Anti-CCR4 Recombinant Antibody (HPAB-0141-LSX) | ELISA, WB, FC, ADCC, CDC, FuncS | Mouse IgG2b |
| HPAB-0143-LSX | Human Anti-CCR4 Recombinant Antibody (HPAB-0143-LSX) | ELISA, WB, FC, ADCC, CDC, FuncS | Human IgG |
| HPAB-0144-LSX | Human Anti-CCR4 Recombinant Antibody (HPAB-0144-LSX) | ELISA, WB, FC, ADCC, CDC | Human IgG |
| HPAB-0145-LSX | Human Anti-CCR4 Recombinant Antibody (HPAB-0145-LSX) | ELISA, WB, FC, ADCC, CDC | Human IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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