Afuco™ Anti-CD248 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-773) (CAT#: AFC-TAB-773)
This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant chimeric/humanized hybrid (mouse/human) antibody expressed in CHO binding to human CD248. It is a monoclonal antibody designed for the treatment of cancer.
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Subcellular Location and Protein Expression
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line ASC TERT1
(Immunofluorescent staining of human cell line ASC TERT1 shows localization to nucleoplasm & plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/51856/1774_B3_8_cr5950f83255423_selected.jpg
(Immunofluorescent staining of human cell line ASC TERT1 shows localization to nucleoplasm & plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/51856/1774_B3_8_cr5950f83255423_selected.jpg
Figure 2 IF staining of human cell line BJ
(Immunofluorescent staining of human cell line BJ shows localization to nucleoplasm & plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/51856/1368_F10_1_blue_red_green.jpg
(Immunofluorescent staining of human cell line BJ shows localization to nucleoplasm & plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/51856/1368_F10_1_blue_red_green.jpg
Figure 3 IF staining of human cell line Hep G2
(Immunofluorescent staining of human cell line Hep G2 shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/51856/1293_C11_1_blue_red_green.jpg
(Immunofluorescent staining of human cell line Hep G2 shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/51856/1293_C11_1_blue_red_green.jpg
Figure 4 Cerebral cortex
(Neuropil
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/51856/120429_B_9_5.jpg
(Neuropil
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/51856/120429_B_9_5.jpg
Figure 5 Colon
(Goblet cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/51856/120429_A_9_3.jpg
(Goblet cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/51856/120429_A_9_3.jpg
Figure 6 Kidney
(Cells in glomeruli
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/51856/120429_A_8_5.jpg
(Cells in glomeruli
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/51856/120429_A_8_5.jpg
Figure 7 RNA cell line category: Cell line enhanced (ASC diff, ASC TERT1, BJ, BJ hTERT+, fHDF/TERT166, HSkMC, U-2197)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000174807-CD248
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000174807-CD248
Specifications
- Immunogen
- The details of the immunogen for this antibody are not available.
- Host Species
- Chimeric
- Derivation
- Chimeric (mouse/human)
- Type
- ADCC enhanced antibody
- Species Reactivity
- Human
- Applications
- Neut, ELISA, IF, IP, FuncS, FC
- Conjugate
- Unconjugated
- Generic Name
- Ontuxizumab
- Related Disease
- Solid tumors
Product Property
- Purity
- >95% by SDS-PAGE
- Storage
- Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- CD248; CD248 molecule, endosialin; CD164 sialomucin like 1, CD164L1, CD248 antigen, endosialin; endosialin; TEM1; tumor endothelial marker 1; 2610111G01Rik; CD164 sialomucin-like 1; CD248 antigen, endosialin; CD164L1;
- Gene ID
- 57124
- UniProt ID
- Q9HCU0
Related Resources
Please refer to Ontuxizumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Ontuxizumab.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "ontuxizumab"
Anti-CD248 Recombinant Antibody (Ontuxizumab)Recombinant chimeric/humanized hybrid (mouse/human) antibody expressed in CHO binding to human CD248. Ontuxizumab is a monoclonal antibody designed for the treatment of cancer.
See other products for "Cd248"
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Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-289-sdAb | Recombinant Anti-Mouse Cd248 VHH Single Domain Antibody | WB, ICC, ChiP, FA, ELISA | Llama VHH |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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