Anti-CD28 (clone 5.11A1) Recombinant Antibody Coupled Liposome (VS-1024-FY21) (CAT#: VS-1024-FY21)

• Potential Clinical Applications
• Potentially kill T cell lines (e.g. CCRFCEM)

• Clone
• 5.11A1

• Antibody Type
• IgG

• Antibody Host
• Mouse

• Antibody Reactivity
• Human

• Antibody Description
• This product is a recombinant antibody derived from mice, specifically engineered to target the CD28 receptor. CD28 is a crucial co-stimulatory molecule that plays a significant role in the activation and regulation of T cells, which are essential components of the immune system. By binding to CD28, this antibody can modulate T cell responses, making it valuable for various applications in immunology research and therapeutic development.

• Storage
• See in the COA

• Storage Shelf Time
• See in the COA

• Target
• CD28

• Introduction
• CD28 (CD28 Molecule) is a Protein Coding gene. Diseases associated with CD28 include Mycosis Fungoides and Sezary's Disease. Among its related pathways are Th2 Differentiation Pathway and RET signaling. Gene Ontology (GO) annotations related to this gene include identical protein binding and SH3/SH2 adaptor activity. An important paralog of this gene is CTLA4.

• Alternative Names
• CD28 Molecule; CD28 Antigen; Tp44; T-Cell-Specific Surface Glycoprotein CD28; T-Cell-Specific Surface Glycoprotein; CD28 Antigen (Tp44)

• Full Name
• CD28 Molecule

• Gene ID
• 940

• UniProt ID
• P10747

• Cellular Localization
• Cell membrane

• Post Translation Modifications
• Phosphorylated by LCK (PubMed:7568038).
  Dephosphorylated by PTPN11 (PubMed:36114179).
  ( P10747-CD28_HUMAN )
  [Isoform 3]: Tyrosine phosphorylated induced by CD40LG. ( P10747-CD28_HUMAN )
  Glycosylation at Asn37, Asn129, Asn71, Asn92, and Asn105 ( NX_P10747 [NX_P10747-1] )
  Modification sites at PhosphoSitePlus ( P10747 )
  Glycosylation from GlyGen (P10747) 5 sites, 4 N-linked glycans (1 site)

• Protein Refseq
• NP_001230006.1; NP_001230007.1; NP_001397910.1; NP_006130.1

• Function
• Receptor that plays a role in T-cell activation, proliferation, survival and the maintenance of immune homeostasis (PubMed:1650475, 7568038).
  Functions not only as an amplifier of TCR signals but delivers unique signals that control intracellular biochemical events that alter the gene expression program of T-cells.

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