Anti-CD28 (clone 5.11A1) Recombinant Antibody Coupled Liposome (VS-1024-FY21) (CAT#: VS-1024-FY21)
The lipid vesicles that are conjugated to anti-CD28 antibodies have the potential to elicit a nonspecific activation of autoreactive T cells, raising concerns about their impact on immune homeostasis. However, the limited ability of these vesicles to target tumor cells effectively could hinder their therapeutic efficacy in activating cytotoxic T cell responses against cancers. Consequently, further studies are essential to explore the intricate relationship between this antibody binding, immune regulation, and the overall anti-cancer properties of the lipid vesicles in various experimental models.

(Non-germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/70003/161787_A_9_8.jpg

(Non-germinal center cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/70003/161787_A_6_8.jpg

(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000178562-CD28

(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000178562-CD28
Specifications
- Potential Clinical Applications
- Potentially kill T cell lines (e.g. CCRFCEM)
Product Composition
- Clone
- 5.11A1
- Antibody Type
- IgG
- Antibody Host
- Mouse
- Antibody Reactivity
- Human
- Antibody Description
- This product is a recombinant antibody derived from mice, specifically engineered to target the CD28 receptor. CD28 is a crucial co-stimulatory molecule that plays a significant role in the activation and regulation of T cells, which are essential components of the immune system. By binding to CD28, this antibody can modulate T cell responses, making it valuable for various applications in immunology research and therapeutic development.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- CD28
- Introduction
- CD28 (CD28 Molecule) is a Protein Coding gene. Diseases associated with CD28 include Mycosis Fungoides and Sezary's Disease. Among its related pathways are Th2 Differentiation Pathway and RET signaling. Gene Ontology (GO) annotations related to this gene include identical protein binding and SH3/SH2 adaptor activity. An important paralog of this gene is CTLA4.
- Alternative Names
- CD28 Molecule; CD28 Antigen; Tp44; T-Cell-Specific Surface Glycoprotein CD28; T-Cell-Specific Surface Glycoprotein; CD28 Antigen (Tp44)
- Full Name
- CD28 Molecule
- Gene ID
- 940
- UniProt ID
- P10747
- Cellular Localization
- Cell membrane
- Post Translation Modifications
- Phosphorylated by LCK (PubMed:7568038).
Dephosphorylated by PTPN11 (PubMed:36114179).
( P10747-CD28_HUMAN )
[Isoform 3]: Tyrosine phosphorylated induced by CD40LG. ( P10747-CD28_HUMAN )
Glycosylation at Asn37, Asn129, Asn71, Asn92, and Asn105 ( NX_P10747 [NX_P10747-1] )
Modification sites at PhosphoSitePlus ( P10747 )
Glycosylation from GlyGen (P10747) 5 sites, 4 N-linked glycans (1 site)
- Protein Refseq
- NP_001230006.1; NP_001230007.1; NP_001397910.1; NP_006130.1
- Function
- Receptor that plays a role in T-cell activation, proliferation, survival and the maintenance of immune homeostasis (PubMed:1650475, 7568038).
Functions not only as an amplifier of TCR signals but delivers unique signals that control intracellular biochemical events that alter the gene expression program of T-cells.
Related Resources
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "CD28"
Select a product category from the dropdown menu below to view related products.
CAT | Product Name | Application | Type |
---|---|---|---|
MOB-0424ZL | Mouse Anti-CD28 Recombinant Antibody (clone CBLS-209) | FC, IP, WB, IHC, FuncS | Mouse IgG1 |
MOB-0354MZ | Mouse Anti-CD28 Recombinant Antibody (clone DD29.1) | ELISA | Mouse IgG1 |
FAMAB-0013-CN | Mouse Anti-CD28 Recombinant Antibody (clone AV7) | FC | Mouse IgG |
FN-267CQ | Mouse Anti-CD28 Recombinant Antibody (clone 9.3) | Stim, Activ | Mouse IgG2a, κ |
VS13-YC159 | Rabbit Anti-CD28 Recombinant Antibody (VS13-YC159) | IHC-P | Rabbit IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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