Anti-CD33 (clone W24p67.6) Recombinant Antibody Coupled Liposome (VS-1024-FY154)
CAT#: VS-1024-FY154
Anti-CD33 antibody liposomes represent a cutting-edge approach in the realm of targeted cancer therapy, specifically aimed at acute myeloid leukemia (AML). By leveraging the unique properties of liposomes, these formulations enable the precise delivery of therapeutic agents directly to CD33-expressing tumor cells, thereby maximizing their therapeutic impact while minimizing collateral damage to healthy tissues. This innovative strategy not only enhances treatment efficacy but also aims to improve patient outcomes by reducing the systemic side effects commonly associated with traditional chemotherapy regimens.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line PC-3
Immunofluorescent staining of human cell line PC-3 shows localization to nucleoplasm & plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/64807/1186_A4_3_selected.jpg
Subcellular Location and Protein Expression
Figure 2 IHC staining of human lymph node
Immunohistochemical staining of human lymph node shows membranous and cytoplasmic positivity in germinal center cells and non-germinal center cells.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/35832/113039_A_9_8_selected.jpg
Subcellular Location and Protein Expression
Figure 3 IHC staining of human tonsil
Immunohistochemical staining of human tonsil shows cytoplasmic positivity in germinal center cells and non-germinal center cells.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/11442/26430_A_6_8_selected.jpg
Subcellular Location and Protein Expression
Figure 4 IF staining of human cell line RH-30
Immunofluorescent staining of human cell line RH-30 shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/64807/1413_G6_1_red_green.jpg
Subcellular Location and Protein Expression
Figure 5 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/64807/1200_A4_2_red_green.jpg
Normal Tissue
Figure 6 Kidney
Cells in tubules
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/79996/170702_A_9_5.jpg
Normal Tissue
Figure 7 Lymph node
Non-germinal center cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/79996/170702_A_9_8.jpg
Normal Tissue
Figure 8 Spleen
Cells in red pulp
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/79996/170702_B_8_4.jpg
RNA Expression
Figure 9 RNA cell line category: Cell line enhanced (HEL, HL-60, HMC-1, NB-4, RPMI-8226, THP-1, U-937)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000105383-CD33
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More Infomation
Specifications
- Potential Clinical Applications
- Leukaemia
Product Composition
- Clone
- W24p67.6
- Antibody Type
- IgG1
- Antibody Host
- Mouse
- Antibody Reactivity
- Human
- Antibody Description
- The W24p67.6 antibody targets CD33 (Siglec-3), which is a 67 kDa type 1 transmembrane sialoadhesin protein belonging to the immunoglobulin superfamily. The immonogen is FMY9S5 cells containing the CD33 gene.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- CD33
- Introduction
- CD33 (CD33 Molecule) is a Protein Coding gene. Diseases associated with CD33 include Gallbladder Lymphoma and Extracutaneous Mastocytoma. Among its related pathways are Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers and Innate Immune System. Gene Ontology (GO) annotations related to this gene include receptor activity and carbohydrate binding. An important paralog of this gene is SIGLEC6.
- Alternative Names
- CD33 Molecule; Sialic Acid-Binding Ig-Like Lectin 3; CD33 Antigen (Gp67); SIGLEC-3; SIGLEC3; Gp67
- Full Name
- CD33 Molecule
- Gene ID
- 945
- UniProt ID
- P20138
- Sequence Similarities
- Belongs to the immunoglobulin superfamily.
- Cellular Localization
- Cell membrane
- Post Translation Modifications
- Glycosylated.
Glycosylation at Asn-100 is critical for regulating ligand recognition.
- Protein Refseq
- XP_011525833.1; XP_011525834.1; XP_016882997.1; XP_016882998.1; XP_016882999.1
- Function
- Sialic-acid-binding immunoglobulin-like lectin (Siglec) that plays a role in mediating cell-cell interactions and in maintaining immune cells in a resting state (PubMed:10611343, 11320212, 15597323).
Preferentially recognizes and binds alpha-2,3- and more avidly alpha-2,6-linked sialic acid-bearing glycans (PubMed:7718872).
Upon engagement of ligands such as C1q or syalylated glycoproteins, two immunoreceptor tyrosine-based inhibitory motifs (ITIMs) located in CD33 cytoplasmic tail are phosphorylated by Src-like kinases such as LCK (PubMed:10887109, 28325905).
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Datasheet
MSDS
COA
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-321-sdAb | Recombinant Anti-human CD33 VHH Single Domain Antibody | WB, IP, ChiP, Neut, ELISA | Llama VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-013 | Humanized Anti-CD33 Recombinant Antibody (TAB-013) | IF, IP, Neut, FuncS, ELISA, FC, WB | Humanized (from mouse) IgG4, κ |
| TAB-H37 | Anti-Human CD33 Recombinant Antibody (Gemtuzumab Ozogamicin) | ELISA, FC, IP, FuncS, IF, Neut, IHC | IgG |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| AGTO-G008E | Anti-CD33 immunotoxin (scFv)-PE | Cytotoxicity assay, Function study | |
| AGTO-G008G | Anti-CD33 immunotoxin (scFv)-Gel | Cytotoxicity assay, Function study | |
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| AGTO-L050G | anti-CD33 immunotoxin M195 (IgG)-Gel | Cytotoxicity assay, Functional assay |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-119LC | Mouse Anti-CD33 Recombinant Antibody (TAB-119LC) | ELISA, IF, RIA | Mouse IgG |
| TAB-120LC | Mouse Anti-CD33 Recombinant Antibody (TAB-120LC) | ELISA, Cyt | Mouse IgG |
| TAB-121LC | Mouse Anti-CD33 Recombinant Antibody (TAB-121LC) | ELISA | Mouse IgG |
| TAB-122LC | Mouse Anti-CD33 Recombinant Antibody (TAB-122LC) | ELISA, Cyt | Mouse IgG |
| TAB-124LC | Mouse Anti-CD33 Recombinant Antibody (TAB-124LC) | ELISA, FC | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-123LC | Anti-Human CD33 Recombinant Antibody | FC | Human antibody |
| TAB-146LC | Human Anti-CD33 Recombinant Antibody (TAB-146LC) | ELISA | Human IgG |
| TAB-123LC-S(P) | Anti-Human CD33 Recombinant Antibody scFv Fragment | FC | Human antibody |
| TAB-123LC-F(E) | Anti-Human CD33 Recombinant Antibody Fab Fragment | FC | Human antibody |
| TAB-146LC-F(E) | Human Anti-CD33 Recombinant Antibody; Fab Fragment (TAB-146LC-F(E)) | ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-013LC | Recombinant Anti-Human CD33 Antibody (Fab glycosylation) | ELISA | Humanized antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-341CQ | Mouse Anti-CD33 Recombinant Antibody (clone WM53) | FC, IHC-Fr, ICC, IP, WB, Block | Mouse IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0553 | Hi-Affi™ Rabbit Anti-CD33 Recombinant Antibody (clone DS553AB) | WB, ICC, IP | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-471CQ | Anti-Human CD33 Recombinant Antibody (TAB-471CQ) | ELISA, IHC, FC, IP, IF, FuncS | IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0077-LSX-F(E) | Mouse Anti-CD33 Recombinant Antibody; Fab Fragment (HPAB-0077-LSX-F(E)) | ELISA, FC | Mouse Fab |
| HPAB-0078-LSX-F(E) | Mouse Anti-CD33 Recombinant Antibody; Fab Fragment (HPAB-0078-LSX-F(E)) | ELISA, FC | Mouse Fab |
| HPAB-0079-LSX-F(E) | Mouse Anti-CD33 Recombinant Antibody; Fab Fragment (HPAB-0079-LSX-F(E)) | ELISA, FC | Mouse Fab |
| HPAB-0080-LSX-F(E) | Human Anti-CD33 Recombinant Antibody; Fab Fragment (HPAB-0080-LSX-F(E)) | ELISA | Human Fab |
| HPAB-0081-LSX-F(E) | Human Anti-CD33 Recombinant Antibody; Fab Fragment (HPAB-0081-LSX-F(E)) | ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-471CQ | Afuco™ Anti-CD33 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-471CQ) | ELISA, IHC, FC, IP, IF, FuncS | ADCC enhanced antibody |
| AFC-TAB-756 | Afuco™ Anti-CD33 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-756) | IF, IP, Neut, FuncS, ELISA, FC | ADCC enhanced antibody |
| AFC-TAB-013 | Afuco™ Anti-CD33 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-013) | IF, IP, Neut, FuncS, ELISA, FC | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1993LY | Human Anti-CD33 Recombinant Antibody (HPAB-1993LY) | FC, ELISA | Humanized IgG |
| HPAB-1994LY | Human Anti-CD33 Recombinant Antibody (HPAB-1994LY) | FC, ELISA | Humanized IgG |
| HPAB-1995LY | Human Anti-CD33 Recombinant Antibody (HPAB-1995LY) | FC, ELISA | Humanized IgG |
| HPAB-1996LY | Human Anti-CD33 Recombinant Antibody (HPAB-1996LY) | FC, ELISA | Humanized IgG |
| HPAB-1997LY | Human Anti-CD33 Recombinant Antibody (HPAB-1997LY) | FC, ELISA | Humanized IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1993LY-S(P) | Human Anti-CD33 Recombinant Antibody; scFv Fragment (HPAB-1993LY-S(P)) | FC, ELISA | Humanized scfv |
| HPAB-1994LY-S(P) | Human Anti-CD33 Recombinant Antibody; scFv Fragment (HPAB-1994LY-S(P)) | FC, ELISA | Humanized scfv |
| HPAB-1995LY-S(P) | Human Anti-CD33 Recombinant Antibody; scFv Fragment (HPAB-1995LY-S(P)) | FC, ELISA | Humanized scfv |
| HPAB-1996LY-S(P) | Human Anti-CD33 Recombinant Antibody; scFv Fragment (HPAB-1996LY-S(P)) | FC, ELISA | Humanized scfv |
| HPAB-1997LY-S(P) | Human Anti-CD33 Recombinant Antibody; scFv Fragment (HPAB-1997LY-S(P)) | FC, ELISA | Humanized scfv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0924-YC24 | Rabbit Anti-CD33 Antibody (VS-0924-YC24) - Cancer Stem Cell Marker | IHC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0225-XY35 | CytoStream™ Mouse Anti-CD33 Recombinant Antibody (clone HIM3-4) | FC | Mouse IgG1, kappa |
| VS-0225-XY36 | CytoStream™ Mouse Anti-CD33 Recombinant Antibody (clone P67.6) | FC | Mouse IgG1, kappa |
| VS-0225-XY37 | CytoStream™ Mouse Anti-CD33 Recombinant Antibody (clone WM53) | FC | Mouse IgG1, kappa |
| VS13-YC160 | CytoStream™ Mouse Anti-CD33 Recombinant Antibody (VS13-YC160) | IHC-P, FC | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-FY84 | Mouse Anti-CD33 scFv-Fc Chimera (VS-0425-FY84) | FC, IF | Mouse IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC365 | Recombinant Anti-CD33 Vesicular Antibody, EV Displayed (VS-0425-YC365) | ELISA, FC, Neut, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY1159 | Anti-CD33 Immunohistochemistry Kit | IHC | |
| VS-0525-XY1160 | Anti-Human CD33 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-YC28 | Recombinant Anti-CD33 (IgV domain x IgC domain) Biparatopic Antibody, Tandem scFv | ELISA | Tandem scFv |
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