Recombinant Anti-CD38 Biparatopic Antibody, Asymmetric sdAb-Fab
CAT#: VS-0525-YC12
This anti-CD38 biparatopic antibody unites two heavy chain-only antibodies targeting non-competing epitopes on CD38. The biparatopic antibody binds with high affinity, synergizing to maximize CD38 inhibition and consequently enhancing intracellular nicotinamide adenine dinucleotide (NAD+) levels and SIRT activities.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line A549
Immunofluorescent staining of human cell line A549 shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/22132/1126_F5_3_selected.jpg
Normal Tissue
Figure 2 Colon
Endothelial cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/22132/51753_A_9_3.jpg
Normal Tissue
Figure 3 Prostate
Glandular cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/22132/51753_A_1_5.jpg
Normal Tissue
Figure 4 Lymph node
Germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/22132/51753_A_7_8.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enhanced (Daudi, Karpas-707, MOLT-4, REH, RPMI-8226, U-266/70, U-698)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000004468-CD38
❮
❯
Specifications
- Host Animal 1
- Human
- Host Animal 2
- Human
- Specificity
- Human CD38
- Species Reactivity
- Human
- Type
- Asymmetric sdAb-Fab
- Valency
- 1 + 1
- Purity
- >90%
- Purification
- Affinity purified
- Applications
- ELISA, Inhib
- Concentration
- Lot specific
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid freeze-thaw cycles.
- Long Name
- CD38 Molecule
Target
- Introduction
- The protein encoded by this gene is a non-lineage-restricted, type II transmembrane glycoprotein that synthesizes and hydrolyzes cyclic adenosine 5'-diphosphate-ribose, an intracellular calcium ion mobilizing messenger. The release of soluble protein and the ability of membrane-bound protein to become internalized indicate both extracellular and intracellular functions for the protein. This protein has an N-terminal cytoplasmic tail, a single membrane-spanning domain, and a C-terminal extracellular region with four N-glycosylation sites. Crystal structure analysis demonstrates that the functional molecule is a dimer, with the central portion containing the catalytic site. It is used as a prognostic marker for patients with chronic lymphocytic leukemia.
- Alternative Names
- ADPRC1; cADPR1; ADPRC 1
- Gene ID
- 952
- UniProt ID
- P28907
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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| CAT | Product Name | Application | Type |
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| TAB-151LC | Mouse Anti-CD38 Recombinant Antibody (TAB-151LC) | ELISA | Mouse IgG, κ |
| TAB-151LC-S(P) | Mouse Anti-CD38 Recombinant Antibody; scFv Fragment (TAB-151LC-S(P)) | ELISA | Mouse scFv |
| TAB-151LC-F(E) | Mouse Anti-CD38 Recombinant Antibody; Fab Fragment (TAB-151LC-F(E)) | ELISA | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-152LC | Human Anti-CD38 Recombinant Antibody (TAB-152LC) | FC, FuncS | Human IgG |
| TAB-153LC | Human Anti-CD38 Recombinant Antibody (TAB-153LC) | ELISA, FC, FuncS | Human IgG1 |
| TAB-154LC | Human Anti-CD38 Recombinant Antibody (TAB-154LC) | ELISA, FC, IF, FuncS | Human IgG1 |
| TAB-155LC | Human Anti-CD38 Recombinant Antibody (TAB-155LC) | ELISA, FC | Human IgG1 |
| TAB-156LC | Human Anti-CD38 Recombinant Antibody (TAB-156LC) | ELISA, FC | Human IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-349CQ | Rat Anti-CD38 Recombinant Antibody (clone NIMR-5) | Neut, FC, IHC-Fr, IP, BA | Rat IgG2a, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0556 | Hi-Affi™ Rabbit Anti-CD38 Recombinant Antibody (clone DS556AB) | FC, ICC, IHC-P, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1357LY-S(P) | Human Anti-CD38 Recombinant Antibody; scFv Fragment (HPAB-1357LY-S(P)) | ELISA | Human scfv |
| HPAB-1358LY-S(P) | Human Anti-CD38 Recombinant Antibody; scFv Fragment (HPAB-1358LY-S(P)) | ELISA | Human scfv |
| HPAB-1359LY-S(P) | Human Anti-CD38 Recombinant Antibody; scFv Fragment (HPAB-1359LY-S(P)) | ELISA | Human scfv |
| HPAB-1360LY-S(P) | Human Anti-CD38 Recombinant Antibody; scFv Fragment (HPAB-1360LY-S(P)) | ELISA | Human scfv |
| HPAB-1361LY-S(P) | Human Anti-CD38 Recombinant Antibody; scFv Fragment (HPAB-1361LY-S(P)) | ELISA | Human scfv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0467LY-F(E) | Mouse Anti-CD38 Recombinant Antibody (clone S5B8); Fab Fragment | ELISA, Block | Mouse Fab |
| HPAB-0468LY-F(E) | Mouse Anti-CD38 Recombinant Antibody (clone S5A10); Fab Fragment | ELISA, Block | Mouse Fab |
| HPAB-0469LY-F(E) | Mouse Anti-CD38 Recombinant Antibody (clone S5B7); Fab Fragment | ELISA, Block | Mouse Fab |
| HPAB-0470LY-F(E) | Mouse Anti-CD38 Recombinant Antibody (clone S5B5); Fab Fragment | ELISA, Block | Mouse Fab |
| HPAB-0471LY-F(E) | Mouse Anti-CD38 Recombinant Antibody (clone S5D3); Fab Fragment | ELISA, Block | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-0299-CN | Rabbit Anti-CD38 Recombinant Antibody (clone CBACN-115) | WB, IHC | Rabbit IgG |
| HPAB-0262-YJ | Human Anti-CD38 Recombinant Antibody (HPAB-0262-YJ) | FuncS | Human IgG4 |
| HPAB-0527-WJ | Human Anti-CD38 Recombinant Antibody (HPAB-0527-WJ) | ELISA, FuncS | Human IgG1 |
| HPAB-0528-WJ | Human Anti-CD38 Recombinant Antibody (HPAB-0528-WJ) | ELISA | Human IgG1 |
| HPAB-0529-WJ | Human Anti-CD38 Recombinant Antibody (HPAB-0529-WJ) | ELISA, WB | Human IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-YC775 | AbPlus™ Anti-CD38 Magnetic Beads (VS-0724-YC775) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0225-XY44 | CytoStream™ Mouse Anti-CD38 Recombinant Antibody (clone 14.27) | FC | Mouse IgG2b, kappa |
| VS-0225-XY45 | CytoStream™ Mouse Anti-CD38 Recombinant Antibody (clone HIT2) | FC | Mouse IgG1, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-FY60 | Human Anti-CD38 (clone OKT10) scFv-Fc Chimera | ELISA | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY363 | Anti-CD38 Immunohistochemistry Kit | IHC | |
| VS-0525-XY1168 | Anti-Mouse CD38 Immunohistochemistry Kit | IHC | |
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