Provided is monoclonal antibody against CD4, the receptor on T cells for the HIV envelope glycoprotein gp 120. The antibody competes with HIV/gpl20 for CD4 binding.
Figure 1 Mouse Anti-CD4 Antibody (clone M-T151) in ELISA.
Levels of soluble CD4 in sera from rheumatoid arthritis patients treated with CD4 monoclonal antibody (mAb) M-T151. A sandwich enzyme-linked immunosorbent assay was used to determine soluble CD4 levels, and recombinant soluble CD4 was used as standard. Absorption with immobilized anti-mouse IgG completely removed soluble CD4, indicating that all soluble CD4 was complexed with M-T151. Values are the mean and SD of 14 treatment courses in 10 patients.
Reiter, C., Kakavand, B., Rieber, E. P., Riethmüller, G., Schattenkirchner, M., & Krüger, K. (1991). Treatment of rheumatoid arthritis with monoclonal CD4 antibody M‐T151. Clinical results and immunopharmacologic effects in an open study, including repeated administration. Arthritis & Rheumatism: Official Journal of the American College of Rheumatology, 34(5), 525-536.
Figure 2 Mouse Anti-CD4 Antibody (clone M-T151) in Toxicity.
Toxicity of M-T151-ricin immunotoxins to CEM and Nalm-6 cells exposed to immunotoxin for 1h before incubation. Panel A: CEM cells were incubated in the presence of different concentrations of ricin (○-○), M-T151-bl.ricin (■-■), or M-T151-n.bl.ricin (□-□ ) for 1 h at 4°C, washed once with cold medium, and incubated for 24 h at 37°C before pulsing with [3H] leucine. Panel B: Nalm-6 cells were incubated in the presence of ricin or M-T151-ricin ITs.
Wawrzynczak, E. J., Watson, G. J., Cumber, A. J., Henry, R. V., Parnell, G. D., Rieber, E. P., & Thorpe, P. E. (1991). Blocked and non-blocked ricin immunotoxins against the CD4 antigen exhibit higher cytotoxic potency than a ricin A chain immunotoxin potentiated with ricin B chain or with a ricin B chain immunotoxin. Cancer Immunology, Immunotherapy, 32(5), 289-295.
Figure 3 Mouse Anti-CD4 Antibody (clone M-T151) in Toxicity.
Potentiation of M-T151-ricin-A-chain toxicity to CEM cells by ricin B chain and GAMIg-ricin-B-chain. CEM cells were incubated in the presence of different concentrations of M-T151-ricin-A-chain for 1 h at 4 °C, washed three times with cold medium, then incubated in the presence of medium alone (●-●), ricin B chain (▲-▲) at a concentration of 10 nM, or goat anti-(mouse Ig)-ricin-B-chain (△-△ ) at a concentration of 10 nM with respect to the B chain for 24 h at 37 °C and pulsed with [3H]leucine for a further 24 h. Measurements of [3H]leucine incorporation are expressed as a percentage of incorporation of cultures in medium alone, or with ricin B chain or goat anti-(mouse Ig)-ficin-B-chain as appropriate.
Wawrzynczak, E. J., Watson, G. J., Cumber, A. J., Henry, R. V., Parnell, G. D., Rieber, E. P., & Thorpe, P. E. (1991). Blocked and non-blocked ricin immunotoxins against the CD4 antigen exhibit higher cytotoxic potency than a ricin A chain immunotoxin potentiated with ricin B chain or with a ricin B chain immunotoxin. Cancer Immunology, Immunotherapy, 32(5), 289-295.
Figure 4 Mouse Anti-CD4 Antibody (clone M-T151) in ACTIV.
Activation of human complement by anti-CD4 mAb. Deposition of complement components C3c, C4 and C5 is shown as total fluorescence mean channel after detection by C3-, C4- and C5-specific FITC-conjugated antisera in a FACscan analysis; a, m M-T151 (IgG2a); b, m M-T310 (IgG1); c,m M-T151+m M-T310; d,chim M-T151 (IgG1); e, chim M-T310 (IgG1); f, chim M-T151+chim M-T310.
Weissenhorn, W., Scheuer, W., Kaluza, B., Schwirzke, M., Reiter, C., Flieger, D., ... & Weidle, U. H. (1992). Combinatorial functions of two chimeric antibodies directed to human CD4 and one directed to the α-chain of the human interleukin-2 receptor. Gene, 121(2), 271-278.
Figure 5 Mouse Anti-CD4 Antibody (clone M-T151) in Northern blot.
Northern blot analysis of hybridomas and transfectomas secreting murine and chimeric mAb M-T151 and M-T310.
Weissenhorn, W., Scheuer, W., Kaluza, B., Schwirzke, M., Reiter, C., Flieger, D., ... & Weidle, U. H. (1992). Combinatorial functions of two chimeric antibodies directed to human CD4 and one directed to the α-chain of the human interleukin-2 receptor. Gene, 121(2), 271-278.
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• Confirmed specificity
• High repeatability
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• Animal-free production
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CAT | Product Name | Application | Type |
---|---|---|---|
TAB-039 | Anti-Human CD4 Recombinant Antibody (Zanolimumab) | Neut, ELISA, IF, IP, FuncS, FC, IHC | IgG1 - kappa |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-164 | Anti-Human CD4 Recombinant Antibody (Priliximab) | WB, FuncS, IF, Neut, ELISA, FC, IP | IgG1 - kappa |
TAB-165LC-S(P) | Monkey Anti-CD4 Recombinant Antibody; scFv Fragment (TAB-165LC-S(P)) | FC, SPR, ELISA | Monkey scFv |
TAB-167LC-S(P) | Anti-Human CD4 Recombinant Antibody scFv Fragment (cM-T412) | ELISA | Chimeric antibody (mouse/human) |
TAB-170LC-S(P) | Rat Anti-CD4 Recombinant Antibody; scFv Fragment (TAB-170LC-S(P)) | ELISA, SPR | Rat scFv |
TAB-170LC-F(E) | Human Anti-CD4 Recombinant Antibody; Fab Fragment (TAB-170LC-F(E)) | ELISA, SPR | Chimeric antibody (rat/human) |
CAT | Product Name | Application | Type |
---|---|---|---|
AGTO-G078E | Anti-CD4 immunotoxin M-T151 (IgG)-PE | Cytotoxicity assay, Function study | |
AGTO-G078R | Anti-CD4 immunotoxin M-T151 (IgG)-RTA | Cytotoxicity assay, Function study |
CAT | Product Name | Application | Type |
---|---|---|---|
PSBL-033 | Human Anti-CD4 Recombinant Antibody (clone 17b); scFv Fragment | WB, ELISA, FuncS | Human scFv |
PSBL-034 | Mouse Anti-CD4 Recombinant Antibody (clone 2D5); scFv Fragment | Neut, ELISA, FuncS | Mouse scFv |
PSBL-035 | Mouse Anti-CD4 Recombinant Antibody (clone Q425); scFv Fragment | WB, ELISA, FuncS | Mouse scFv |
HPAB-0792-CN-S(P) | Mouse Anti-CD4 Recombinant Antibody (clone B4); scFv Fragment | ELISA | Mouse scFv |
HPAB-0793-CN-S(P) | Human Anti-CD4 Recombinant Antibody (clone chB4); scFv Fragment | ELISA | Mouse scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
PABL-426 | Human Anti-CD4 Recombinant Antibody (clone 576) | WB, ELISA, FuncS | Human IgG |
PABL-427 | Human Anti-CD4 Recombinant Antibody (clone Hu5A8) | ELISA, Cyt, WB, Neut | Human IgG4 |
FAMAB-0054YC | Mouse Anti-CD4 Recombinant Antibody (clone M-T310) | Neut | Mouse IgG1, κ |
FAMAB-0055YC | Mouse Anti-CD4 Recombinant Antibody (clone M-T404) | Neut | Mouse IgG1, κ |
FAMAB-0056YC | Mouse Anti-CD4 Recombinant Antibody (clone M-T408) | Neut | Mouse IgG1, κ |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-160LC | Anti-Human CD4 Recombinant Antibody (OKT4A) | ELISA, WB | |
TAB-166LC | Anti-Human CD4 Recombinant Antibody (M-T412) | ELISA, Inhib | |
TAB-169LC | Rat Anti-CD4 Recombinant Antibody (TAB-169LC) | ELISA, FC, SPR | Rat IgG |
TAB-173LC | Anti-Human CD4 Recombinant Antibody (IgA F425-Alg8) | ELISA, Inhib | |
TAB-174LC | Mouse Anti-CD4 Recombinant Antibody (TAB-174LC) | ELISA, FC, IHC, Neut, FuncS | Mouse IgG1 |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-161LC | Anti-Human CD4 Recombinant Antibody (gOKT4A-4) | ELISA | Humanized antibody |
TAB-168LC | Anti-Human CD4 Recombinant Antibody (TRX1) | ELISA | Humanized antibody |
TAB-168LC-S(P) | Anti-Human CD4 Recombinant Antibody scFv Fragment (TRX1) | ELISA | Humanized antibody |
TAB-171LC-S(P) | Human Anti-CD4 Recombinant Antibody; scFv Fragment (TAB-171LC-S(P)) | ELISA, SPR | Humanized scFv |
TAB-172LC-S(P) | Human Anti-CD4 Recombinant Antibody; scFv Fragment (TAB-172LC-S(P)) | ELISA | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
Gly-025LC | Recombinant Anti-Human CD4 Antibody (Fab glycosylation) | ELISA | Humanized antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-351CQ | Mouse Anti-CD4 Recombinant Antibody (clone 10C12) | ELISA, WB, IF, Block | Mouse IgG1 |
NEUT-352CQ | Mouse Anti-CD4 Recombinant Antibody (clone 13B8.2) | Block, ELISA, FC, IHC-Fr, WB | Mouse IgG1, κ |
NEUT-355CQ | Mouse Anti-CD4 Recombinant Antibody (clone RPA-T4) | FC, CyTOF, Block, IHC | Mouse IgG1, κ |
NEUT-357CQ | Rat Anti-CD4 Recombinant Antibody (clone MAB0810) | Block, Depletion, Stim | Rat IgG2b |
NEUT-358CQ | Rat Anti-CD4 Recombinant Antibody (clone RM4-5) | FC, CyTOF, Depletion, Block, IHC | Rat IgG2a, κ |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-353CQ | Mouse Anti-CD4 Recombinant Antibody (clone CBL976) | FC, Neut, IF, IHC | Mouse IgG1, κ |
NEUT-354CQ | Recombinant Mouse Anti-CD4 Antibody (CT-4) | Neut, FC, IHC, IHC-Fr, IHC-P, IP | IgG1, κ |
NEUT-356CQ | Mouse Anti-CD4 Recombinant Antibody (clone 3-4F4) | Neut, FC, IHC, IHC-Fr, IP, ICC | Mouse IgG1, κ |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-0560 | Hi-Affi™ Rabbit Anti-CD4 Recombinant Antibody (clone DS560AB) | IHC-P | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
FAMAB-0054-YC-F(E) | Mouse Anti-CD4 Recombinant Antibody (clone M-T310); Fab Fragment | Neut | Mouse Fab |
FAMAB-0055-YC-F(E) | Mouse Anti-CD4 Recombinant Antibody (clone M-T404); Fab Fragment | Neut | Mouse Fab |
FAMAB-0056-YC-F(E) | Mouse Anti-CD4 Recombinant Antibody (clone M-T408); Fab Fragment | Neut | Mouse Fab |
FAMAB-0057-YC-F(E) | Mouse Anti-CD4 Recombinant Antibody (clone M-T151); Fab Fragment | Neut | Mouse Fab |
FAMAB-0048CQ-F(E) | Mouse Anti-CD4 Recombinant Antibody (clone Leu3a); Fab Fragment | ELISA, FC | Mouse Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
AFC-TAB-039 | Afuco™ Anti-CD4 ADCC Recombinant Antibody (Zanolimumab), ADCC Enhanced | Neut, ELISA, IF, IP, FuncS, FC | ADCC enhanced antibody |
AFC-TAB-164 | Afuco™ Anti-CD4 ADCC Recombinant Antibody (Priliximab), ADCC Enhanced | FuncS, IF, Neut, ELISA, FC | ADCC enhanced antibody |
AFC-TAB-260 | Afuco™ Anti-CD4 ADCC Recombinant Antibody (Tregalizumab), ADCC Enhanced | ELISA, FC, IP, FuncS, IF | ADCC enhanced antibody |
AFC-TAB-171 | Afuco™ Anti-CD4 ADCC Recombinant Antibody (Keliximab), ADCC Enhanced | FuncS, IF, Neut, ELISA, FC, IP | ADCC enhanced antibody |
AFC-TAB-107 | Afuco™ Anti-CD4 ADCC Recombinant Antibody (Cedelizumab), ADCC Enhanced | IF, IP, Neut, FuncS, ELISA, FC | ADCC enhanced antibody |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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