Human Anti-CD4 Recombinant Antibody (clone DB81) (CAT#: FAMAB-1058CQ)
This product is a recombinant human antibody that recognizes CD4. The antibody was purified by affinity chromatography. It can be used in Neut, ELISA, FC.
Specific Inquiry
Inhib
Figure 1 Inhibition of HIV-1 Env-mediated fusion by sera from mice immunized with CD4-complexed HIV-1 Env.
era from mice immunized with autologous NIH 3T3 cells expressing HIV-1 Ba-L Env in complex or not with soluble CD4 were tested for inhibition of HIV-1 Env-mediated fusion using Sup-T1 cells chronically infected with HIV-1 Ba-L or IIIB as effector cells.
Burastero, S. E., Frigerio, B., Lopalco, L., Sironi, F., Breda, D., Longhi, R., ... & Lusso, P. (2011). Broad-spectrum inhibition of HIV-1 by a monoclonal antibody directed against a gp120-induced epitope of CD4. PLoS One, 6(7), e22081.
FC
Figure 2 Complement fixation by MAb DB81.
Flow cytometry analysis of PM-1 cells treated with complement (C) plus DB81. Cells were stained with propidium iodide as a marker for cell death. Numbers in panels indicate the percent of stained (complement lysed, dead) cells, which fell within the double arrow markers in the different experimental settings.
Burastero, S. E., Frigerio, B., Lopalco, L., Sironi, F., Breda, D., Longhi, R., ... & Lusso, P. (2011). Broad-spectrum inhibition of HIV-1 by a monoclonal antibody directed against a gp120-induced epitope of CD4. PLoS One, 6(7), e22081.
Specifications
- Immunogen
- Human CD4 complexed with HIV-1 Env (gp120).
- Host Species
- Human
- Type
- Human IgG1
- Specificity
- Human CD4
- Species Reactivity
- Human
- Clone
- DB81
- Applications
- Inhib, FC
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- This antibody has been reported for use in Inhibition and Flow Cytometry.
Target
- Alternative Names
- CD4 Molecule; T-Cell Surface Glycoprotein CD4; T-Cell Surface Antigen T4/Leu-3; CD4 Antigen (P55); CD4 Receptor; CD4 Antigen; CD4mut
- Gene ID
- 920
- UniProt ID
- P01730
Related Resources
Primary Immunodeficiency
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
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ScFv-Fc Chimera Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-039 | Anti-Human CD4 Recombinant Antibody (Zanolimumab) | Neut, ELISA, IF, IP, FuncS, FC, IHC | IgG1 - kappa |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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