Rat Anti-CD4 Recombinant Antibody Hexamer (VS-0924-YC114), CDC Enhanced

Name: Rat Anti-CD4 Recombinant Antibody Hexamer (VS-0924-YC114), CDC Enhanced
SKU: VS-0924-YC114
Rating: 5 (1 reviews)

CAT#: VS-0924-YC114

The product is a rat anti-CD4 antibody hexamer with enhanced complement-dependent cytotoxicity (CDC) activity. This hexameric IgG1 targets human CD4 and includes hexamerization-enhancing mutations, which facilitate hexamer formation to optimize C1q binding and boost CDC efficiency.

Gene Expression

Subcellular Location Figure 1 IF staining of human cell line U-251 MG

Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/11/if_selected.jpg

RNA Expression Figure 2 RNA cell line category: Group enriched (HEL, HL-60, NB-4, THP-1, U-937)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000010610-CD4

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Specifications

Immunogen
Recombinant human CD4

Host Species
Rat

Type
Antibody hexamer

Specificity
Human CD4

Species Reactivity
Human

Molecule Class
~ 900 kDa

Applications
ELISA, FC, CDC

Conjugate
None

Product Property

Clonality
Monoclonal

Purification
Protein G purified

Purity
>95% determined as SDS-PAGE and SEC-HPLC

Aggregation
<5%

Buffer
PBS, pH 7.4

Preservative
No preservatives

Storage
Store at 4°C short term (1-2 weeks). Store at -20°C long term (12 months). Avoid repeated freeze/thaw cycles.

Target

Alternative Names
CD4 Molecule; T-Cell Surface Glycoprotein CD4; T-Cell Surface Antigen T4/Leu-3; CD4 Antigen (P55); CD4 Receptor; CD4 Antigen; CD4mut

Gene ID
920

UniProt ID
P01730

Long Name
CD4 Molecule

Sequence Similarities
The Ig-like V-type domain mediates the interaction with MHCII.

Post Translation Modifications
Palmitoylation and association with LCK contribute to the enrichment of CD4 in lipid rafts. ( P01730-CD4_HUMAN )
Phosphorylated by PKC; phosphorylation at Ser-433 plays an important role for CD4 internalization. ( P01730-CD4_HUMAN )
Glycosylation at Asn296 and Asn325 ( NX_P01730 [NX_P01730-1] )
Ubiquitination at Lys453 ( NX_P01730 [NX_P01730-1] )

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Related Diseases

Primary Immunodeficiency

Downloadable Resources

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Datasheet

Datasheet - VS-0924-YC114.pdf

MSDS

MSDS - VS-0924-YC114.pdf

COA

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