Anti-CD74 (clone LL1) Recombinant Antibody Coupled Liposome (VS-1024-FY310)
CAT#: VS-1024-FY310
Anti-CD74 antibody-conjugated liposomes represent an innovative biotherapeutic strategy tailored for precise drug delivery in the treatment of various diseases, notably cancer and autoimmune conditions. By leveraging the high specificity of anti-CD74 antibodies, these liposomes can target and bind to cells that express the CD74 receptor, significantly improving therapeutic outcomes while reducing potential side effects associated with conventional treatments.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to the Golgi apparatus.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2506/if_selected.jpg
Subcellular Location and Protein Expression
Figure 2 IHC staining of human spleen
Immunohistochemical staining of human spleen shows strong granular cytoplasmic positivity.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10592/ihc_selected.jpg
Subcellular Location and Protein Expression
Figure 3 IHC staining of human tonsil
Immunohistochemical staining of human tonsil shows strong cytoplasmic positivity in germinal center cells and non-germinal center cells.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/79994/170659_A_6_8_selected.jpg
Subcellular Location and Protein Expression
Figure 4 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to the Golgi apparatus.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2506/203_F11_1_blue_red_green.jpg
Normal Tissue
Figure 5 Colon
Mucosal lymphoid cells
Staining:High
Intensity: Strong
Quantity: 75%-25%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2506/6593_A_7_3.jpg
Normal Tissue
Figure 6 Kidney
Cells in glomeruli
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2506/6593_A_8_5.jpg
Normal Tissue
Figure 7 Lymph node
Germinal center cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2506/6593_A_8_8.jpg
Normal Tissue
Figure 8 Tonsil
Germinal center cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2506/6593_A_6_8.jpg
RNA Expression
Figure 9 RNA cell line category: Cell line enhanced (CAPAN-2, Daudi, HDLM-2, REH, RPMI-8226, U-266/70, U-698)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000019582-CD74
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More Infomation
Specifications
- Potential Clinical Applications
- Anti-CD74 antibody-conjugated liposomes are therapeutic and diagnostic agents that can specifically target cells expressing CD74.
Product Composition
- Clone
- LL1
- Antibody Type
- IgG
- Antibody Host
- Human
- Antibody Reactivity
- Human
- Antibody Description
- This is a humanized monoclonal antibody targeting CD74, primarily studied for treating multiple myeloma, non-Hodgkin's lymphoma, and chronic lymphocytic leukemia.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- CD74
- Full Name
- CD74 Molecule
- Cellular Localization
- Cell membrane, Endoplasmic reticulum, Endosome, Golgi apparatus, Lysosome, Membrane
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Downloadable Resources
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Datasheet
MSDS
COA
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-466-VHH | Recombinant Anti-Human CD74 VHH Single Domain Antibody | FUNC, FA, IP, ChiP | Llama VHH |
| TAB-0004CL-VHH | Anti-Human CD74 VHH Single Domain Antibody (TAB-0004CL-VHH) | ELISA, FC, Internalization, Inhib, FuncS | VHH |
| TAB-0005CL-VHH | Anti-Human CD74 VHH Single Domain Antibody (TAB-0005CL-VHH) | ELISA, FC, Internalization, Inhib, FuncS | VHH |
| TAB-0006CL-VHH | Anti-Human CD74 VHH Single Domain Antibody (TAB-0006CL-VHH) | ELISA, FC, Internalization, Inhib, FuncS | VHH |
| TAB-0007CL-VHH | Anti-Human CD74 VHH Single Domain Antibody (TAB-0007CL-VHH) | ELISA, FC, Internalization, Inhib, FuncS | VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0569CL-F(E) | Human Anti-CD74 Recombinant Antibody; Fab Fragment (TAB-0569CL-F(E)) | ELISA, FC | Human Fab |
| TAB-0570CL-F(E) | Human Anti-CD74 Recombinant Antibody; Fab Fragment (TAB-0570CL-F(E)) | ELISA, FC | Human Fab |
| TAB-0571CL-F(E) | Human Anti-CD74 Recombinant Antibody; Fab Fragment (TAB-0571CL-F(E)) | ELISA, FC | Human Fab |
| TAB-0572CL-F(E) | Human Anti-CD74 Recombinant Antibody; Fab Fragment (TAB-0572CL-F(E)) | ELISA, FC | Human Fab |
| TAB-0573CL-F(E) | Human Anti-CD74 Recombinant Antibody; Fab Fragment (TAB-0573CL-F(E)) | ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-408CQ | Mouse Anti-CD74 Recombinant Antibody (clone LN2) | FC, IHC-Fr, IHC-P, ICC, IP, WB, Block | Mouse IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0579 | Hi-Affi™ Rabbit Anti-CD74 Recombinant Antibody (clone DS579AB) | ICC, IHC-P, IP, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0388-FY-S(P) | Human Anti-CD74 Recombinant Antibody; scFv Fragment (HPAB-0388-FY-S(P)) | FC | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0388-FY-F(E) | Human Anti-CD74 Recombinant Antibody; Fab Fragment (HPAB-0388-FY-F(E)) | FC | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS3-XY404 | Mouse Anti-CD74 Recombinant Antibody (clone 2D1B11) | ELISA, WB, FC | Mouse IgG1 |
| VS3-XY405 | Mouse Anti-CD74 Recombinant Antibody (clone 2D1B3) | ELISA, WB, FC | Mouse IgG1 |
| VS3-XY406 | Mouse Anti-CD74 Recombinant Antibody, FITC (clone 4ALN2) | FC, IF | Mouse IgG1 |
| VS3-XY407 | Mouse Anti-CD74 Recombinant Antibody, PE (clone 4ALN2) | FC, IHC, IP, IF, WB | Mouse IgG1 |
| VS3-XY408 | Mouse Anti-CD74 Recombinant Antibody (clone 4ALN2) | FC, IHC, IP, IF, WB | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY55 | AbPlus™ Anti-CD74 Magnetic Beads (4ALN2) | IP, Protein Purification | |
| VS-0724-YC321 | AbPlus™ Anti-CD74 Magnetic Beads (VS-0724-YC321) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1024-XY110 | Mouse Anti-NHP CD74 Recombinant Antibody (clone LN-2) | WB, IHC, IF, FC | Mouse IgG1, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0225-XY71 | CytoStream™ Mouse Anti-CD74 Recombinant Antibody (clone LN2) | FC | Mouse IgG1, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-FY83 | Human Anti-CD74 (clone LL1) scFv-Fc Chimera | FC, ELISA, Cyt | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC330 | Recombinant Anti-CD74 Vesicular Antibody, EV Displayed (VS-0425-YC330) | ELISA, FC, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY1217 | Anti-CD74 Immunohistochemistry Kit | IHC | |
| VS-0525-XY1218 | Anti-Mouse CD74 Immunohistochemistry Kit | IHC |
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