Anti-CD8A (clone YTS169) Recombinant Antibody Coupled Liposome (VS-1024-FY169)
CAT#: VS-1024-FY169
Liposomes conjugated with anti-CD8A antibodies represent a promising strategy to augment T cell-mediated immune responses, particularly in the context of melanoma immunotherapy. By targeting CD8A, these engineered liposomes can effectively recruit and activate cytotoxic T cells, leading to increased tumor infiltration and subsequent destruction of malignant cells. This innovative approach not only aims to improve the tumor microenvironment by reducing immunosuppression but also enhances the overall immune clearance capabilities against the tumor, potentially leading to better patient outcomes.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line SH-SY5Y
Immunofluorescent staining of human cell line SH-SY5Y shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/37756/1373_A3_1_selected.jpg
Subcellular Location and Protein Expression
Figure 2 IF staining of human cell line RH-30
Immunofluorescent staining of human cell line RH-30 shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/37756/1492_D3_2_blue_red_green.jpg
Subcellular Location and Protein Expression
Figure 3 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/37756/1377_A3_1_blue_red_green.jpg
Normal Tissue
Figure 4 Lymph node
Germinal center cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous nuclear
Non-germinal center cells
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous nuclear
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/12/97_A_7_8.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enhanced (JURKAT, MOLT-4, RPMI-8226)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000153563-CD8A
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More Infomation
Specifications
- Potential Clinical Applications
- Melanoma
Product Composition
- Clone
- YTS169
- Antibody Type
- IgG1
- Antibody Host
- Mouse
- Antibody Reactivity
- Human
- Antibody Description
- This is a recombinant mouse monoclonal antibody that has been meticulously developed to specifically recognize and bind to CD8a, a critical marker found on cytotoxic T cells. The high specificity of this antibody facilitates its use in studies aimed at understanding T cell activation and differentiation in immune responses. Its application can also extend to therapeutic areas, potentially aiding in the design of treatments that enhance T cell responses against tumors and infections.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- CD8A
- Introduction
- Enables identical protein binding activity. Acts upstream of or within several processes, including cytotoxic T cell differentiation; defense response to virus; and positive regulation of calcium-mediated signaling. Located in external side of plasma membrane. Is expressed in several structures, including endocrine gland; exocrine gland; genitourinary system; gut; and hemolymphoid system gland. Orthologous to human CD8A (CD8a molecule).
- Alternative Names
- Ly-2; Ly-B; Ly-35; Lyt-2
- Full Name
- CD8a Molecule
- Gene ID
- 12525
- UniProt ID
- P01731
- Cellular Localization
- Cell membrane, Membrane, Secreted
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Datasheet
MSDS
COA
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See other products for "Clone YTS169"
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- Product Name
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-369-VHH | Recombinant Anti-Mouse Cd8a VHH Single Domain Antibody | IHC, ICC, IP, ChiP, Neut | Llama VHH |
| NABG-041 | Recombinant Anti-Human CD8A VHH Single Domain Antibody | IHC, FC, CA, FuncS | Llama VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-184-F(E) | Recombinant Anti-human CD8A Antibody Fab Fragment | WB, ELISA, FuncS | Fab |
| FAMAB-0009-CN-F(E) | Mouse Anti-CD8A Recombinant Antibody (clone CT8); Fab Fragment | FC | Mouse Fab |
| FAMAB-0010-CN-F(E) | Mouse Anti-CD8A Recombinant Antibody (clone EP72); Fab Fragment | FC | Mouse Fab |
| FAMAB-0011-CN-F(E) | Mouse Anti-CD8A Recombinant Antibody (clone 3-298); Fab Fragment | FC | Mouse Fab |
| HPAB-S0183-YC-F(E) | Rat Anti-Cd8a Recombinant Antibody (clone YTS105.18); Fab Fragment | ELISA | Rat Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-184-S(P) | Recombinant Anti-human CD8A Antibody scFv Fragment | IP, IF, Biosensors, FuncS | scFv |
| MHH-184-S(P) | Recombinant Human Anti-human CD8A Antibody scFv Fragment | ELISA, WB, FuncS | scFv |
| HPAB-0188-CN-S(P) | Mouse Anti-CD8A Recombinant Antibody; scFv Fragment (HPAB-0188-CN-S(P)) | FC | Mouse scFv |
| HPAB-0189-CN-S(P) | Mouse Anti-CD8A Recombinant Antibody; scFv Fragment (HPAB-0189-CN-S(P)) | FC | Mouse scFv |
| HPAB-S0183-YC-S(P) | Rat Anti-Cd8a Recombinant Antibody (clone YTS105.18); scFv Fragment | ELISA | Rat scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0512CT | Recombinant Mouse anti-Human CD8A Monoclonal antibody (IJU9b) | FC | |
| HPAB-0188-CN | Mouse Anti-CD8A Recombinant Antibody (HPAB-0188-CN) | FC | Mouse IgG |
| HPAB-0189-CN | Mouse Anti-CD8A Recombinant Antibody (HPAB-0189-CN) | FC | Mouse IgG |
| FAMAB-0009-CN | Mouse Anti-CD8A Recombinant Antibody (clone CT8) | FC | Mouse IgG |
| FAMAB-0010-CN | Mouse Anti-CD8A Recombinant Antibody (clone EP72) | FC | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-428CQ | Mouse Anti-CD8A Recombinant Antibody (clone UCHT4) | FC, IHC-Fr, IHC-P, IP, Separation, Block | Mouse IgG2a, κ |
| NEUT-431CQ | Rat Anti-CD8A Recombinant Antibody (clone 53-6.7) | ICC, IF, FC, IHC-Fr, IP, FuncS, Block | Rat IgG2a, κ |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-429CQ | Mouse Anti-CD8A Recombinant Antibody (clone CT-8) | Neut, FC, IHC, IHC-Fr, IHC-P, IP, ICC | Mouse IgG1, κ |
| NEUT-430CQ | Mouse Anti-CD8A Recombinant Antibody (clone LT8) | WB, Neut | Mouse IgG1 |
| NEUT-433CQ | Mouse Anti-CD8A Recombinant Antibody (clone 76-2-11) | Neut, FC, IHC-Fr, IHC-P, IP | Mouse IgG2a, κ |
| NEUT-434CQ | Mouse Anti-Cd8a Recombinant Antibody (clone OX-8) | WB, Neut, FC, IHC, IHC-Fr, IHC-P, IP, CyTOF® | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0582 | Hi-Affi™ Rabbit Anti-CD8A Recombinant Antibody (clone DS582AB) | IHC | Rabbit IgG |
| MOR-0589 | Hi-Affi™ Rabbit Anti-CD8A Recombinant Antibody (clone DS589AB) | IHC-P | Rabbit IgG |
| MOR-0590 | Hi-Affi™ Rabbit Anti-CD8A Recombinant Antibody (clone DS590AB), PE | FC | Rabbit IgG |
| MOR-0057-FY | Rabbit Anti-CD8A Recombinant Antibody (clone AFY0028) | ICC, IF, IHC-P, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0041-CN | Mouse Anti-CD8A Recombinant Antibody (clone 13C5) | WB, IP, IF | Mouse IgM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1024-XY114 | Mouse Anti-NHP CD8A Recombinant Antibody (clone T8/209) | ELISA | Mouse IgG1, kappa |
| VS-1024-XY112 | Rat Anti-NHP CD8A Recombinant Antibody (clone YTC182.20) | FC | Rat IgG2b |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0225-XY78 | CytoStream™ Mouse Anti-CD8A Recombinant Antibody (VS-0225-XY78) | FC | Mouse IgG2a, kappa |
| VS-0225-XY79 | CytoStream™ Mouse Anti-CD8A Recombinant Antibody (clone SK1) | FC | Mouse IgG1, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY375 | Anti-CD8A Immunohistochemistry Kit | IHC | |
| VS-0525-XY1238 | Anti-Mouse CD8A Immunohistochemistry Kit | IHC | |
| VS-0525-XY1237 | Anti-Human CD8A Immunohistochemistry Kit | IHC | |
| VS-0525-XY1240 | Anti-Rat CD8A Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC377 | Recombinant Anti-CD8A Vesicular Antibody, EV Displayed (VS-0425-YC377) | ELISA, FC, Neut, Cell-uptake |
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