Anti-CD8A (clone YTS169) Recombinant Antibody Coupled Liposome (VS-1024-FY169) (CAT#: VS-1024-FY169)
Liposomes conjugated with anti-CD8A antibodies represent a promising strategy to augment T cell-mediated immune responses, particularly in the context of melanoma immunotherapy. By targeting CD8A, these engineered liposomes can effectively recruit and activate cytotoxic T cells, leading to increased tumor infiltration and subsequent destruction of malignant cells. This innovative approach not only aims to improve the tumor microenvironment by reducing immunosuppression but also enhances the overall immune clearance capabilities against the tumor, potentially leading to better patient outcomes.
More Infomation
Subcellular Location and Protein Expression
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line SH-SY5Y
(Immunofluorescent staining of human cell line SH-SY5Y shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/37756/1373_A3_1_selected.jpg
(Immunofluorescent staining of human cell line SH-SY5Y shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/37756/1373_A3_1_selected.jpg
Figure 2 IF staining of human cell line RH-30
(Immunofluorescent staining of human cell line RH-30 shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/37756/1492_D3_2_blue_red_green.jpg
(Immunofluorescent staining of human cell line RH-30 shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/37756/1492_D3_2_blue_red_green.jpg
Figure 3 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/37756/1377_A3_1_blue_red_green.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/37756/1377_A3_1_blue_red_green.jpg
Figure 4 Lymph node
(Germinal center cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous nuclear
Non-germinal center cells
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous nuclear)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/12/97_A_7_8.jpg
(Germinal center cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous nuclear
Non-germinal center cells
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous nuclear)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/12/97_A_7_8.jpg
Figure 5 RNA cell line category: Cell line enhanced (JURKAT, MOLT-4, RPMI-8226)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000153563-CD8A
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000153563-CD8A
Specifications
- Potential Clinical Applications
- Melanoma
Product Composition
- Clone
- YTS169
- Antibody Type
- IgG1
- Antibody Host
- Mouse
- Antibody Reactivity
- Human
- Antibody Description
- This is a recombinant mouse monoclonal antibody that has been meticulously developed to specifically recognize and bind to CD8a, a critical marker found on cytotoxic T cells. The high specificity of this antibody facilitates its use in studies aimed at understanding T cell activation and differentiation in immune responses. Its application can also extend to therapeutic areas, potentially aiding in the design of treatments that enhance T cell responses against tumors and infections.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- CD8A
- Introduction
- Enables identical protein binding activity. Acts upstream of or within several processes, including cytotoxic T cell differentiation; defense response to virus; and positive regulation of calcium-mediated signaling. Located in external side of plasma membrane. Is expressed in several structures, including endocrine gland; exocrine gland; genitourinary system; gut; and hemolymphoid system gland. Orthologous to human CD8A (CD8a molecule).
- Alternative Names
- Ly-2; Ly-B; Ly-35; Lyt-2
- Full Name
- CD8a Molecule
- Gene ID
- 12525
- UniProt ID
- P01731
- Cellular Localization
- Cell membrane, Membrane, Secreted
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Flow Cytometry (FC) related Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-369-VHH | Recombinant Anti-Mouse Cd8a VHH Single Domain Antibody | IHC, ICC, IP, ChiP, Neut | Llama VHH |
| NABG-041 | Recombinant Anti-Human CD8A VHH Single Domain Antibody | IHC, FC, CA, FuncS | Llama VHH |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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