Rabbit Anti-CDH1 Recombinant Antibody (VS3-CJ618)
CAT#: VS3-CJ618
This product is a rabbit antibody that recognizes human, mouse, and rat CDH1.







Specifications
- Immunogen
- Recombinant protein
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human, Mouse, Rat CDH1
- Species Reactivity
- Human, Mouse, Rat
- Applications
- WB, ICC, IF, IHC, IP, FC
- Conjugate
- Unconjugated
Product Property
- Purification
- Protein A affinity purified
- Purity
- >95% as determined by SDS-PAGE
- Format
- Liquid
- Buffer
- 40% Glycerol, 1% BSA, TBS, pH7.4.
- Preservative
- 0.05% Sodium Azide
- Storage
- Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- This antibody has been tested for use in Western Blot, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Flow Cytometry.
Target
- Alternative Names
- UVO; CDHE; ECAD; LCAM; Arc-1; BCDS1; CD324
- Gene ID
- 999
- UniProt ID
- P12830
- Cellular Localization
- Cell junction, Cell membrane, Endosome, Golgi apparatus, Membrane
- Post Translation Modifications
- During apoptosis or with calcium influx, cleaved by a membrane-bound metalloproteinase (ADAM10), PS1/gamma-secretase and caspase-3 (PubMed:11076937, PubMed:11953314, PubMed:10597309).
Processing by the metalloproteinase, induced by calcium influx, causes disruption of cell-cell adhesion and the subsequent release of beta-catenin into the cytoplasm (PubMed:10597309).
The residual membrane-tethered cleavage product is rapidly degraded via an intracellular proteolytic pathway (PubMed:10597309).
Cleavage by caspase-3 releases the cytoplasmic tail resulting in disintegration of the actin microfilament system (PubMed:11076937).
The gamma-secretase-mediated cleavage promotes disassembly of adherens junctions (PubMed:11953314).
During development of the cochlear organ of Corti, cleavage by ADAM10 at adherens junctions promotes pillar cell separation (By similarity).
N-glycosylation at Asn-637 is essential for expression, folding and trafficking. Addition of bisecting N-acetylglucosamine by MGAT3 modulates its cell membrane location (PubMed:19403558).
Ubiquitinated by a SCF complex containing SKP2, which requires prior phosphorylation by CK1/CSNK1A1. Ubiquitinated by CBLL1/HAKAI, requires prior phosphorylation at Tyr-754.
O-glycosylated. O-manosylated by TMTC1, TMTC2, TMTC3 or TMTC4. Thr-285 and Thr-509 are O-mannosylated by TMTC2 or TMTC4 but not TMTC1 or TMTC3.
- Protein Refseq
- NP_001304113.1; NP_001304114.1; NP_001304115.1
- Function
- Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7.
E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production.
(Microbial infection) Serves as a receptor for Listeria monocytogenes; internalin A (InlA) binds to this protein and promotes uptake of the bacteria.
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
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CAT | Product Name | Application | Type |
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CAT | Product Name | Application | Type |
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CAT | Product Name | Application | Type |
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MOR-0611 | Hi-Affi™ Rabbit Anti-CDH1 Recombinant Antibody (clone DS611AB) | ICC, IF, IHC-P, IHC-P, IP, WB | Rabbit IgG |
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CAT | Product Name | Application | Type |
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HPAB-0464-WJ | Mouse Anti-CDH1 Recombinant Antibody (clone SC10.6) | ELISA, FC | Mouse IgG |
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HPAB-0466-WJ-F(E) | Mouse Anti-CDH1 Recombinant Antibody (clone SC10.17); Fab Fragment | ELISA, FC | Mouse Fab |
HPAB-0467-WJ-F(E) | Human Anti-CDH1 Recombinant Antibody (clone hSC10.17); Fab Fragment | ELISA, FC | Humanized Fab |
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CAT | Product Name | Application | Type |
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HPAB-0464-WJ-S(P) | Mouse Anti-CDH1 Recombinant Antibody (clone SC10.6); scFv Fragment | ELISA, FC | Mouse scFv |
HPAB-0465-WJ-S(P) | Mouse Anti-CDH1 Recombinant Antibody (clone SC10.15); scFv Fragment | ELISA, FC | Mouse scFv |
HPAB-0466-WJ-S(P) | Mouse Anti-CDH1 Recombinant Antibody (clone SC10.17); scFv Fragment | ELISA, FC | Mouse scFv |
HPAB-0467-WJ-S(P) | Human Anti-CDH1 Recombinant Antibody (clone hSC10.17); scFv Fragment | ELISA, FC | Humanized scFv |
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