Rabbit Anti-CDKN1C Recombinant Antibody (clone R08-5E7) (CAT#: VS3-XY3309)
It is a recombinant rabbit antibody specific for CDKN1C (Cyclin dependent kinase inhibitor 1C), which plays a role in maintenance of the non-proliferative state throughout life. It specifically targets human, mouse and rat CDKN1C. This product has been tested using Western Blot, Immunohistochemistry-Paraffin, Immunoprecipitation, Immunocytochemistry or Immunofluorescence.
Specific Inquiry
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm, nuclear bodies & cytosol.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2924/32_C5_1_selected.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm, nuclear bodies & cytosol.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2924/32_C5_1_selected.jpg
Figure 2 Cerebral cortex
(Endothelial cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Nuclear Glial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: nuclear Neuronal cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2924/155493_B_8_5.jpg
(Endothelial cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Nuclear Glial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: nuclear Neuronal cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2924/155493_B_8_5.jpg
Figure 3 Kidney
(Cells in glomeruli Staining: High Intensity: Strong Quantity: 75%-25% Collecting ducts Staining: Medium Intensity: Strong Quantity: <25% Distal tubules Staining: Medium Intensity: Strong Quantity: <25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2924/155493_A_8_5.jpg
(Cells in glomeruli Staining: High Intensity: Strong Quantity: 75%-25% Collecting ducts Staining: Medium Intensity: Strong Quantity: <25% Distal tubules Staining: Medium Intensity: Strong Quantity: <25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2924/155493_A_8_5.jpg
Figure 4 Testis
(Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2924/155493_A_4_6.jpg
(Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2924/155493_A_4_6.jpg
Figure 5 Placenta
(Decidual cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Nuclear Trophoblastic cells Staining: Medium Intensity: Strong Quantity: <25% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2924/155493_A_1_7.jpg
(Decidual cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Nuclear Trophoblastic cells Staining: Medium Intensity: Strong Quantity: <25% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2924/155493_A_1_7.jpg
Figure 6 RNA cell line category: Cell line enhanced (EFO-21, HeLa, RPMI-8226, SH-SY5Y, SiHa, SK-MEL-30)
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000129757-CDKN1C
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000129757-CDKN1C
Specifications
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human, Mouse and Rat CDKN1C
- Species Reactivity
- Human, Mouse, Rat
- Clone
- R08-5E7
- Applications
- WB, IHC-P, ICC, IF, IP
- Related Disease
- Beckwith-Wiedemann syndrome (BWS); Intrauterine growth retardation, metaphyseal dysplasia, adrenal hypoplasia congenita, and genital anomalies (IMAGE)
Product Property
- Clonality
- Monoclonal
- Aggregation
- < 5%
- Format
- Liquid
- Buffer
- PBS (pH 7.4), 150 mM NaCl and 50% glycerol
- Preservative
- 0.02% sodium azide
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- WB: 1/500-1/1000
IHC: 1/50-1/100
IF: 1/50-1/200
IP: 1/20
Target
- Alternative Names
- BWS; WBS; p57; BWCR; KIP2; p57Kip2
- Gene ID
- 1028
- UniProt ID
- P49918
- Long Name
- Cyclin dependent kinase inhibitor 1C
- Sequence Similarities
- Belongs to the CDI family.
- Cellular Localization
- Nucleus
- Post Translation Modifications
- Modification sites at PhosphoSitePlus (P49918)
Modification sites at neXtProt (NX_P49918)
- Protein Refseq
- NP_000067.1; NP_001116102.1; NP_001116103.1
- Function
- Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non-proliferative state throughout life.
Recommended Products
Isotype Control
Recommended Dilution Buffer
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "CDKN1C"
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0641 | Hi-Affi™ Rabbit Anti-CDKN1C Recombinant Antibody (clone DS641AB) | WB, IP, IHC-P, ICC, FC | Rabbit IgG |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0160F | Mouse Anti-CDKN1C Recombinant Antibody (MOB-0160F) | IHC-P, IF | Mouse IgG |
| MOB-0161F | Mouse Anti-CDKN1C Recombinant Antibody (MOB-0161F) | IHC-P, IF | Mouse IgG |
| MOB-0162F | Mouse Anti-CDKN1C Recombinant Antibody (MOB-0162F) | WB | Mouse IgG |
| ZG-0348C | Mouse Anti-CDKN1C Recombinant Antibody (ZG-0348C) | WB, ELISA | Mouse IgG |
| VS3-CJ1002 | Mouse Anti-CDKN1C Recombinant Antibody (clone ABT-P57) | IHC-P | Mouse IgG2a, κ |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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