Rabbit Anti-CDKN1C Recombinant Antibody (clone R08-5E7)
CAT#: VS3-XY3309
It is a recombinant rabbit antibody specific for CDKN1C (Cyclin dependent kinase inhibitor 1C), which plays a role in maintenance of the non-proliferative state throughout life. It specifically targets human, mouse and rat CDKN1C. This product has been tested using Western Blot, Immunohistochemistry-Paraffin, Immunoprecipitation, Immunocytochemistry or Immunofluorescence.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm, nuclear bodies & cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2924/32_C5_1_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Endothelial cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Nuclear Glial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: nuclear Neuronal cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2924/155493_B_8_5.jpg
Normal Tissue
Figure 3 Kidney
Cells in glomeruli Staining: High Intensity: Strong Quantity: 75%-25% Collecting ducts Staining: Medium Intensity: Strong Quantity: <25% Distal tubules Staining: Medium Intensity: Strong Quantity: <25%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2924/155493_A_8_5.jpg
Normal Tissue
Figure 4 Testis
Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2924/155493_A_4_6.jpg
Normal Tissue
Figure 5 Placenta
Decidual cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Nuclear Trophoblastic cells Staining: Medium Intensity: Strong Quantity: <25% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2924/155493_A_1_7.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enhanced (EFO-21, HeLa, RPMI-8226, SH-SY5Y, SiHa, SK-MEL-30)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000129757-CDKN1C
❮
❯
Specifications
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human, Mouse and Rat CDKN1C
- Species Reactivity
- Human, Mouse, Rat
- Clone
- R08-5E7
- Applications
- WB, IHC-P, ICC, IF, IP
- Related Disease
- Beckwith-Wiedemann syndrome (BWS); Intrauterine growth retardation, metaphyseal dysplasia, adrenal hypoplasia congenita, and genital anomalies (IMAGE)
Product Property
- Clonality
- Monoclonal
- Aggregation
- < 5%
- Format
- Liquid
- Buffer
- PBS (pH 7.4), 150 mM NaCl and 50% glycerol
- Preservative
- 0.02% sodium azide
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- WB: 1/500-1/1000
IHC: 1/50-1/100
IF: 1/50-1/200
IP: 1/20
Target
- Alternative Names
- BWS; WBS; p57; BWCR; KIP2; p57Kip2
- Gene ID
- 1028
- UniProt ID
- P49918
- Long Name
- Cyclin dependent kinase inhibitor 1C
- Sequence Similarities
- Belongs to the CDI family.
- Cellular Localization
- Nucleus
- Post Translation Modifications
- Modification sites at PhosphoSitePlus (P49918)
Modification sites at neXtProt (NX_P49918)
- Protein Refseq
- NP_000067.1; NP_001116102.1; NP_001116103.1
- Function
- Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non-proliferative state throughout life.
REVIEWS AND Q&AS
CITATIONS
RESOURCES
DOWNLOADS
RELATED PRODUCTS
Inquiry
Navs
Customer Review
There are currently no Customer reviews or questions for VS3-XY3309. Click the button above to contact us or submit your feedback about this product.
Submit Your Publication
Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Isotype Control
- CAT
- Product Name
Recommended Dilution Buffer
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "CDKN1C"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0641 | Hi-Affi™ Rabbit Anti-CDKN1C Recombinant Antibody (clone DS641AB) | WB, IP, IHC-P, ICC, FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0160F | Mouse Anti-CDKN1C Recombinant Antibody (MOB-0160F) | IHC-P, IF | Mouse IgG |
| MOB-0161F | Mouse Anti-CDKN1C Recombinant Antibody (MOB-0161F) | IHC-P, IF | Mouse IgG |
| MOB-0162F | Mouse Anti-CDKN1C Recombinant Antibody (MOB-0162F) | WB | Mouse IgG |
| VS3-XY480 | Mouse Anti-CDKN1C Recombinant Antibody (clone 3E3) | ELISA, WB | Mouse IgG1 |
| VS7-HM686 | Mouse Anti-CDKN1C Recombinant Antibody (clone CBL147HM) | WB, ELISA | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS3-QX221 | Mouse Anti-CDKN1C Recombinant Antibody (clone 522CT9.5.1) | WB | Mouse IgM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY413 | Anti-CDKN1C Immunohistochemistry Kit | IHC | |
| VS-0525-XY1338 | Anti-Mouse CDKN1C Immunohistochemistry Kit | IHC | |
| VS-0525-XY1337 | Anti-Human CDKN1C Immunohistochemistry Kit | IHC |
Specific Inquiry
Add to compare
See Our Custom Production in Action
Popular Products
Application: ELISA, IP, FC, FuncS, Neut, IF, ICC
Application: ELISA, Neut, IF, IP, FC, FuncS
Application: ELISA, IP, FC, FuncS, Neut, IF, WB
Application: IF, IP, Neut, FuncS, ELISA, FC, ICC
Application: WB, Neut, ELISA, IF, IP, FuncS, FC
Application: Neut, Inhib, FC, ELISA
-5.jpg)
Application: ELISA, IHC, FC, IP, IF, Inhib
Application: Inhib, FC, WB
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
