Anti-CEACAM5 (clone A5B7) Recombinant Antibody Coupled Liposome (VS-1024-FY144) (CAT#: VS-1024-FY144)

• Potential Clinical Applications
• Colorectal cancer, Breast cancer

• Clone
• A5B7

• Antibody Type
• IgG1

• Antibody Host
• Human

• Antibody Reactivity
• Human

• Antibody Description
• This innovative recombinant human monoclonal antibody is specifically engineered to target CEACAM5, a cell adhesion molecule commonly associated with certain types of cancer. By binding to CEACAM5, this antibody may facilitate the targeting and destruction of cancerous cells that express this biomarker, potentially enhancing therapeutic efficacy. The design of this monoclonal antibody incorporates advanced techniques to ensure high specificity and affinity for CEACAM5, minimizing off-target effects. As a result, this therapeutic agent holds promise for improving treatment outcomes in patients with tumors exhibiting elevated levels of CEACAM5 expression.

• Storage
• See in the COA

• Storage Shelf Time
• See in the COA

• Target
• CEACAM5

• Introduction
• This gene encodes a cell surface glycoprotein that represents the founding member of the carcinoembryonic antigen (CEA) family of proteins. The encoded protein is used as a clinical biomarker for gastrointestinal cancers and may promote tumor development through its role as a cell adhesion molecule. Additionally, the encoded protein may regulate differentiation, apoptosis, and cell polarity. This gene is present in a CEA family gene cluster on chromosome 19. Alternative splicing results in multiple transcript variants.

• Alternative Names
• CEACAM-5; CD66e; CEA; Meconium antigen 100

• Full Name
• Carcinoembryonic Antigen Related Cell Adhesion Molecule 5

• Gene ID
• 1048

• UniProt ID
• P06731

• Sequence Similarities
• Belongs to the immunoglobulin superfamily. CEA family.

• Cellular Localization
• Cell membrane, Membrane

• Post Translation Modifications
• Complex immunoreactive glycoprotein with a MW of 180 kDa comprising 60% carbohydrate.

• Protein Refseq
• NP_001278413.1; NP_001295327.1; NP_004354.3

• Function
• Cell surface glycoprotein that plays a role in cell adhesion, intracellular signaling and tumor progression (PubMed:2803308, PubMed:10910050, PubMed:10864933).
  Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6 (PubMed:2803308).
  Plays a role as an oncogene by promoting tumor progression; induces resistance to anoikis of colorectal carcinoma cells (PubMed:10910050).
  (Microbial infection) Receptor for E.coli Dr adhesins. Binding of E.coli Dr adhesins leads to dissociation of the homodimer.

• VS-1024-FY174
• Anti-CEACAM1 (clone W24V173) Recombinant Antibody Coupled Liposome (VS-1024-FY174)

• VS-1024-FY25
• Anti-CEACAM5 (clone MFE-23) Recombinant Antibody Coupled Liposome (VS-1024-FY25)

• TAB-408LC
• Anti-Human CEACAM5 Recombinant Antibody (A5B7)

• TAB-408LC-S(P)
• Anti-Human CEACAM5 Recombinant Antibody scFv Fragment (A5B7)

• TAB-408LC-F(E)
• Anti-Human CEACAM5 Recombinant Antibody Fab Fragment (A5B7)

• VS-0125-FY89
• Human Anti-CEACAM5 (clone A5B7) scFv-Fc Chimera

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