Anti-CEACAM5 (clone MFE-23) Recombinant Antibody Coupled Liposome (VS-1024-FY25)
CAT#: VS-1024-FY25
This murine anti-CEA single-chain variable fragment (scFv) antibody has been specifically isolated due to its high affinity for carcinoembryonic antigen (CEA), a marker often overexpressed in various cancers. Current research focuses on utilizing these scFv antibodies in the development of immunoliposomes, which are engineered liposomes designed to deliver therapeutic agents selectively to cancer cells. The targeted drug delivery capability of these immunoliposomes holds great promise for enhancing the efficacy of cancer treatments while minimizing side effects, paving the way for new and improved therapeutic strategies in oncology and other medical fields.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line HaCaT
Immunofluorescent staining of human cell line HaCaT shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/19758/1660_G5_2_selected.jpg
Subcellular Location
Figure 2 IHC staining of human duodenum
Immunohistochemical staining of human duodenum shows strong cytoplasmic positivity in a subset of leukocytes.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/11041/ihc_selected.jpg
Normal Tissue
Figure 3 Colon
Endocrine cells
Staining: High
Intensity: Strong
Enterocytes
Staining: High
Intensity: Strong
Quantity:>75%
Enterocytes - Gradient
Gradient: Ascending
Enterocytes - Microvilli
Staining: High
Intensity: Strong
Goblet cells
Staining: High
Intensity: Strong
Quantity:>75%
Mucosal lymphoid cells
Staining: Medium
Intensity: Strong
Quantity: <25%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/21/19_A_7_3.jpg
Normal Tissue
Figure 4 Rectum
Endocrine cells
Staining: High
Intensity: Strong
Enterocytes
Staining: High
Intensity: Strong
Quantity:>75%
Enterocytes - Microvilli
Staining: High
Intensity: Strong
Goblet cells
Staining: High
Intensity: Strong
Quantity:>75%
Mucosal lymphoid cells
Staining: Medium
Intensity: Strong
Quantity: <25%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/21/19_A_6_3.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enriched (OE19)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000105388-CEACAM5
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More Infomation
Specifications
- Potential Clinical Applications
- Human colon carcinoma
- Immunoliposomes Method
- Immunoliposomes were created by inserting scFv'-conjugated micelles into preformed PEG-liposomes. Liposomes made of EPC:Chol:mPEG2000-DSPE (6.75:3:0.25) containing 0.3 mol% DiI dye were prepared via film hydration-extrusion. Mal-PEG2000-DSPE micelles were formed by dissolving dried lipids in water and heat incubation. Reduced scFv were dialyzed to remove TCEP and mixed with micelles at a 5:1 molar ratio, followed by a 30-minute coupling reaction. Post-insertion of micelles occurred at specific temperatures for dual targeting with anti-EGFR and anti-CEA scFv', and unbound scFv were removed using gel filtration. Liposome size was measured, and micelles were stained with fluorescent labels for tracking during co-insertion.
Product Composition
- Clone
- MFE-23
- Antibody Type
- scFv
- Antibody Host
- Mouse
- Antibody Reactivity
- Human
- Antibody Description
- This is a mouse anti-human CEA antibody. It is a monoclonal antibody specifically designed to target carcinoembryonic antigen (CEA), which is a glycoprotein involved in cell adhesion and is generally used as a tumor marker. CEA is often associated with certain types of cancers, particularly colorectal cancer, and its levels can be elevated in other malignancies as well.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- CEACAM5
- Introduction
- This gene encodes a cell surface glycoprotein that represents the founding member of the carcinoembryonic antigen (CEA) family of proteins. The encoded protein is used as a clinical biomarker for gastrointestinal cancers and may promote tumor development through its role as a cell adhesion molecule. Additionally, the encoded protein may regulate differentiation, apoptosis, and cell polarity. This gene is present in a CEA family gene cluster on chromosome 19. Alternative splicing results in multiple transcript variants.
- Alternative Names
- Carcinoembryonic Antigen Related Cell Adhesion Molecule 5; Carcinoembryonic Antigen-Related Cell Adhesion Molecule 5; Meconium Antigen 100; CEA; Carcinoembryonic Antigen; CD66e Antigen; CD66e
- Full Name
- Carcinoembryonic Antigen Related Cell Adhesion Molecule 5
- Gene ID
- 1048
- UniProt ID
- P06731
- Sequence Similarities
- Belongs to the immunoglobulin superfamily. CEA family.
- Cellular Localization
- Cell membrane, Membrane
- Post Translation Modifications
- Complex immunoreactive glycoprotein with a MW of 180 kDa comprising 60% carbohydrate.
- Protein Refseq
- NP_001278413.1; NP_001295327.1; NP_004354.3
- Function
- Cell surface glycoprotein that plays a role in cell adhesion, intracellular signaling and tumor progression (PubMed:2803308, PubMed:10910050, PubMed:10864933).
Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6 (PubMed:2803308).
Plays a role as an oncogene by promoting tumor progression; induces resistance to anoikis of colorectal carcinoma cells (PubMed:10910050).
(Microbial infection) Receptor for E.coli Dr adhesins. Binding of E.coli Dr adhesins leads to dissociation of the homodimer.
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COA
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1138z | Mouse Anti-CEACAM5 Recombinant Antibody (clone 32B10) | WB, IP, IF, FC | Mouse IgG1, κ |
| MRO-0231-CN | Rabbit Anti-CEACAM5 Recombinant Antibody (clone JM93-28) | WB, IF, IHC | Rabbit IgG |
| VS3-QX225 | Mouse Anti-CEACAM5 Recombinant Antibody (clone 1C7) | WB, IHC, ICC, FC, ELISA | Mouse IgG1 |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| NABL-080 | Recombinant Anti-human CEACAM5 VHH Single Domain Antibody | WB, ELISA, IHC, FC, FuncS | Llama VHH |
| TAB-002LC-VHH | Anti-Human CEACAM5 Recombinant Antibody(VHH library) | SPR, FC, ELISA | Single domain antibody |
| HPAB-0204-FY | Recombinant llama Anti-CEACAM5 Antibody (HPAB-0204-FY) | ADCC, ELISA | llama VHH |
| HPAB-0205-FY | Recombinant llama Anti-CEACAM5 Antibody (HPAB-0205-FY) | ADCC, E | llama VHH |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-703 | Anti-Human CEACAM5 Recombinant Antibody (Altumomab) | IF, IP, Neut, FuncS, ELISA, FC, IHC | IgG1 |
| TAB-418LC-F(E) | Anti-Human CEACAM5 Recombinant Antibody Fab Fragment (COL-Human 9) | FC, WB | |
| TAB-419LC-F(E) | Anti-Human CEACAM5 Recombinant Antibody Fab Fragment (COL-Human 12) | FC, WB | |
| TAB-420LC-F(E) | Anti-Human CEACAM5 Recombinant Antibody Fab Fragment (COL-Human 13) | FC, WB | |
| TAB-421LC-F(E) | Anti-Human CEACAM5 Recombinant Antibody Fab Fragment (COL-Human 15) | FC, WB |
| CAT | Product Name | Application | Type |
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| AGTO-L003E | anti-CEACAM5 immunotoxin BDI-1 (IgG)-PE | Cytotoxicity assay, Functional assay | |
| AGTO-L003R | anti-CEACAM5 immunotoxin BDI-1 (IgG)-RTA | Cytotoxicity assay, Functional assay | |
| AGTO-L004E | anti-CEACAM5 immunotoxin BDI-1 (scFv)-PE | Cytotoxicity assay, Functional assay | |
| AGTO-L004R | anti-CEACAM5 immunotoxin BDI-1 (scFv)-RTA | Cytotoxicity assay, Functional assay |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-409LC | Human Anti-CEACAM5 Recombinant Antibody (TAB-409LC) | SPR, ELISA, FC | Humanized antibody |
| TAB-412LC | Human Anti-CEACAM5 Recombinant Antibody (TAB-412LC) | ELISA, FC | Chimeric (Mouse/Human) IgG1 |
| TAB-413LC | Human Anti-CEACAM5 Recombinant Antibody (TAB-413LC) | Cyt, ELISA, FC, Inhib | Chimeric (Mouse/Human) IgG1 |
| TAB-409LC-S(P) | Human Anti-CEACAM5 Recombinant Antibody; scFv Fragment (TAB-409LC-S(P)) | SPR, ELISA, FC | Humanized scFv |
| TAB-412LC-S(P) | Human Anti-CEACAM5 Recombinant Antibody; scFv Fragment (TAB-412LC-S(P)) | FC, ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-411LC-S(P) | Human Anti-Human CEACAM5 Recombinant Antibody scFv Fragment | ELISA | Human antibody |
| TAB-411LC-F(E) | Human Anti-Human CEACAM5 Recombinant Antibody Fab Fragment | ELISA | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-410LC-F(E) | Human Anti-CEACAM5 Recombinant Antibody; Fab Fragment (TAB-410LC-F(E)) | ELISA | Humanized Fab |
| TAB-414LC-F(E) | Human Anti-CEACAM5 Recombinant Antibody; Fab Fragment (TAB-414LC-F(E)) | FC, ELISA | Humanized Fab |
| TAB-415LC-F(E) | Human Anti-CEACAM5 Recombinant Antibody; Fab Fragment (TAB-415LC-F(E)) | FC, ELISA | Humanized Fab |
| TAB-416LC-F(E) | Human Anti-CEACAM5 Recombinant Antibody; Fab Fragment (TAB-416LC-F(E)) | FC, ELISA | Humanized Fab |
| TAB-417LC-F(E) | Human Anti-CEACAM5 Recombinant Antibody; Fab Fragment (TAB-417LC-F(E)) | IF, ELISA | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0118MZ | Chicken Anti-CEACAM5 Polyclonal IgY | WB | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0649 | Hi-Affi™ Rabbit Anti-CEACAM5 Recombinant Antibody (clone DS649AB) | IHC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC2749 | PE-A*02:01/Human CEACAM5 (IMIGVLVGV) MHC Tetramer | FCM | |
| MHC-LC2750 | PE-A*02:02/Human CEACAM5 (IMIGVLVGV) MHC Tetramer | FCM | |
| MHC-LC2751 | PE-A*02:03/Human CEACAM5 (IMIGVLVGV) MHC Tetramer | FCM | |
| MHC-YF053 | DRB1*04:01/Human CEA (YACFVSNLATGRNNS) MHC Monomer | MHC Multimer | |
| MHC-YF059 | DRB1*04:05/Human CEA (LWWVNNQSLPVSP) MHC Monomer | MHC Multimer |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0155-FY-S(P) | Mouse Anti-CEACAM5 Recombinant Antibody; scFv Fragment (HPAB-0155-FY-S(P)) | Activ | Humanized scFv |
| HPAB-0243-FY-S(P) | Mouse Anti-CEACAM5 Recombinant Antibody scFv Fragment (HPAB-0243-FY-S(P)) | ELISA | Mouse scFv |
| HPAB-0348-YJ-S(P) | Mouse Anti-CEACAM5 Recombinant Antibody (clone 10E1); scFv Fragment | ELISA, IHC | Mouse scFv |
| HPAB-1094WJ-S(P) | Mouse Anti-CEACAM5 Recombinant Antibody; scFv Fragment (HPAB-1094WJ-S(P)) | ELISA, FC | Mouse scFv |
| HPAB-2106-FY-S(P) | Human Anti-CEACAM5 Recombinant Antibody (clone CEA6); scFv Fragment | ELISA, FC, Inhib | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0155-FY-F(E) | Mouse Anti-CEACAM5 Recombinant Antibody; Fab Fragment (HPAB-0155-FY-F(E)) | Activ | Humanized Fab |
| HPAB-0243-FY-F(E) | Human Anti-CEACAM5 Recombinant Antibody Fab Fragment (HPAB-0243-FY-F(E)) | ELISA | Chimeric (mouse/human) Fab |
| HPAB-0348-YJ-F(E) | Mouse Anti-CEACAM5 Recombinant Antibody (clone 10E1); Fab Fragment | ELISA, IHC | Mouse Fab |
| HPAB-1094WJ-F(E) | Mouse Anti-CEACAM5 Recombinant Antibody; Fab Fragment (HPAB-1094WJ-F(E)) | ELISA, FC | Mouse Fab |
| HPAB-2106-FY-F(E) | Human Anti-CEACAM5 Recombinant Antibody (clone CEA6); Fab Fragment | ELISA, FC, Inhib | Human Fab, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-703 | Afuco™ Anti-CEACAM5 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-703) | IF, IP, Neut, FuncS, ELISA, FC | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1024-XY62 | Mouse Anti-NHP CEACAM5 Recombinant Antibody (clone SPM506) | IHC, IF, FC | Mouse IgG1, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0125-FY29 | Human Anti-CEACAM5 (clone MFE-23) scFv-Fc Chimera | BI | Human IgG1, scFv-Fc |
| VS-0125-FY89 | Human Anti-CEACAM5 (clone A5B7) scFv-Fc Chimera | ELISA | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC97 | Recombinant Anti-CEACAM5 Vesicular Antibody, EV Displayed (VS-0425-YC97) | ELISA, FC, Neut, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY1355 | Anti-CEACAM5 Immunohistochemistry Kit | IHC | |
| VS-0525-XY1356 | Anti-Human CEACAM5 Immunohistochemistry Kit | IHC |
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