Recombinant Anti-CFTR Biparatopic Antibody, Tandem scFv (CAT#: VS-0525-YC32)

• Host Animal 1
• Camelid

• Host Animal 2
• Camelid

• Specificity
• Human CFTR

• Species Reactivity
• Human

• Type
• Tandem sdAb

• Valency
• 1 + 1

• Epitope 1
• The edge of the α/β-core region

• Epitope 2
• The structurally diverse region (SDR) of NBD1

• Purity
• >90%

• Purification
• Affinity purified

• Applications
• ELISA, FC, Pull-down

• Concentration
• Lot specific

• Buffer
• PBS, pH 7.4

• Preservative
• No preservatives

• Storage
• Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid freeze-thaw cycles.

• Long Name
• Cystic Fibrosis Transmembrane Conductance Regulator

• Introduction
• This gene encodes a member of the ATP-binding cassette (ABC) transporter superfamily. The encoded protein functions as a chloride channel, making it unique among members of this protein family, and controls ion and water secretion and absorption in epithelial tissues. Channel activation is mediated by cycles of regulatory domain phosphorylation, ATP-binding by the nucleotide-binding domains, and ATP hydrolysis. Mutations in this gene cause cystic fibrosis, the most common lethal genetic disorder in populations of Northern European descent. The most frequently occurring mutation in cystic fibrosis, DeltaF508, results in impaired folding and trafficking of the encoded protein. Multiple pseudogenes have been identified in the human genome.

• Alternative Names
• CF; MRP7; ABC35; ABCC7; CFTR/MRP; TNR-CFTR; dJ760C5.1

• Gene ID
• 1080

• UniProt ID
• P13569

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