Recombinant Anti-CFTR Biparatopic Antibody, Tandem scFv
CAT#: VS-0525-YC32
The recombinant Anti-CFTR biparatopic antibody, tandem scFv, binds two distinct areas of the CFTR protein. This antibody features tandem scFv arms designed to interact simultaneously with the edge of the α/β-core region and the structurally diverse region (SDR) of NBD1 with high affinity.
Gene Expression
Normal Tissue
Figure 1 High expression in pancreas
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/21939/169902_A_1_3_val_selected.jpg
Normal Tissue
Figure 2 Low expression in skeletal muscle.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1951/160344_B_3_6_val_selected.jpg
Normal Tissue
Figure 3 Low expression in lymph node
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/21939/169902_A_9_8_val_selected.jpg
Normal Tissue
Figure 4 Pancreas
Exocrine glandular cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/21939/169902_A_1_3.jpg
RNA Expression
Figure 5 RNA cell line category: Group enriched (CACO-2, MOLT-4, U-266/70)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000001626-CFTR
❮
❯
Specifications
- Host Animal 1
- Camelid
- Host Animal 2
- Camelid
- Specificity
- Human CFTR
- Species Reactivity
- Human
- Type
- Tandem sdAb
- Valency
- 1 + 1
- Epitope 1
- The edge of the α/β-core region
- Epitope 2
- The structurally diverse region (SDR) of NBD1
- Purity
- >90%
- Purification
- Affinity purified
- Applications
- ELISA, FC, Pull-down
- Concentration
- Lot specific
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid freeze-thaw cycles.
- Long Name
- Cystic Fibrosis Transmembrane Conductance Regulator
Target
- Introduction
- This gene encodes a member of the ATP-binding cassette (ABC) transporter superfamily. The encoded protein functions as a chloride channel, making it unique among members of this protein family, and controls ion and water secretion and absorption in epithelial tissues. Channel activation is mediated by cycles of regulatory domain phosphorylation, ATP-binding by the nucleotide-binding domains, and ATP hydrolysis. Mutations in this gene cause cystic fibrosis, the most common lethal genetic disorder in populations of Northern European descent. The most frequently occurring mutation in cystic fibrosis, DeltaF508, results in impaired folding and trafficking of the encoded protein. Multiple pseudogenes have been identified in the human genome.
- Alternative Names
- CF; MRP7; ABC35; ABCC7; CFTR/MRP; TNR-CFTR; dJ760C5.1
- Gene ID
- 1080
- UniProt ID
- P13569
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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See other products for "CFTR"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1704z | Mouse Anti-CFTR Recombinant Antibody (clone 28C12) | WB, IF, IHC | Mouse IgG1 |
| MOB-0481CT | Recombinant Mouse anti-Human CFTR Monoclonal antibody (N4B8) | FC, IHC-Fr, IHC-P | |
| MRO-1772-CN | Rabbit Anti-CFTR Polyclonal Antibody (MRO-1772-CN) | WB, IF, IHC, FC | Rabbit IgG |
| PABS-0273 | Camelid Anti-CFTR Recombinant Antibody (PABS-0273) | Thermal shift assay (DSF), Isothermal titration microcalorimertry (ITC), Differential scanning calorimetry (DSC), FC, pull-down, ELISA, FuncS | Camelid VHH |
| PABS-0274 | Camelid Anti-CFTR Recombinant Antibody (clone G3a) | Thermal shift assay (DSF), Isothermal titration microcalorimertry (ITC), Differential scanning calorimetry (DSC), FC, Pull-down, ELISA, FuncS | Camelid VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-458CQ | Mouse Anti-CFTR Recombinant Antibody (clone CF3) | Block, FC, ICC, IF, IHC, IHC-P, IP, WB | Mouse IgM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NBD-0019-YJ-VHH | Camelid Anti-CFTR Recombinant Single Domain Antibody (NBD-0019-YJ-VHH) | ELISA, Thermal stabilization | Camelid VHH |
| NBD-0020-YJ-VHH | Camelid Anti-CFTR Recombinant Single Domain Antibody (NBD-0020-YJ-VHH) | ELISA | Camelid VHH |
| NBD-0021-YJ-VHH | Camelid Anti-CFTR Recombinant Single Domain Antibody (NBD-0021-YJ-VHH) | ELISA, Thermal stabilization | Camelid VHH |
| NBD-0022-YJ-VHH | Camelid Anti-CFTR Recombinant Single Domain Antibody (NBD-0022-YJ-VHH) | ELISA, Thermal stabilization | Camelid VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY436 | Anti-CFTR Immunohistochemistry Kit | IHC | |
| VS-0525-XY1406 | Anti-Mouse CFTR Immunohistochemistry Kit | IHC | |
| VS-0525-XY1405 | Anti-Human CFTR Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC395 | Recombinant Anti-CFTR Vesicular Antibody, EV Displayed (VS-0425-YC395) | ELISA, FC, Cell-uptake |
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