Recombinant Anti-CII Biparatopic Antibody, Tandem scFv (Clone mAb1-5 x Clone CB313)

CAT#: VS-0525-YC34

The recombinant Anti-CII biparatopic antibody, tandem scFv (Clone mAb1-5 x Clone CB313), is developed to target two distinct epitopes on CII. This configuration uses a tandem scFv, where the mAb1-5 scFv is focused on a conformational epitope on the triple-helical CII and is fused at the N-terminus to the CB313 scFv, which targets the C1 epitope (amino acids 316-333).

Specifications

  • Host Animal 1
  • Mouse
  • Host Animal 2
  • Mouse
  • Specificity
  • Human CII
  • Species Reactivity
  • Human
  • Type
  • Tandem scFv
  • Valency
  • 1 + 1
  • Clone 1
  • mAb1-5
  • Clone 2
  • CB313
  • Epitope 1
  • A conformational epitope on triple helical CII.
  • Epitope 2
  • The C1 epitope (aa 316-333)
  • Purity
  • >90%
  • Purification
  • Affinity purified
  • Applications
  • ELISA
  • Concentration
  • Lot specific
  • Buffer
  • PBS, pH 7.4
  • Preservative
  • No preservatives
  • Storage
  • Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid freeze-thaw cycles.
  • Long Name
  • type II collagen

Target

  • Introduction
  • Collagen type II (CII) is a relevant joint-specific autoantigen in the pathogenesis of rheumatoid arthritis (RA).
  • Alternative Names
  • Collagen type II; CII; Type II collagen
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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