Rabbit Anti-CIRBP Recombinant Antibody (clone R01-4B2)
CAT#: VS3-FY1687
This is a rabbit recombinant monoclonal antibody, it was produced by immunized with recombinant protein of human CIRBP. It specifically detects human CIRBP by WB, IHC, IP assay. The R01-4B2 is recommended for dilution of target protein by western blot (dilution 1/500-1/1000), immunohistochemistry (dilution 1/50-1/100), immunoprecipitation (dilution 1/20).
Specifications
- Immunogen
- Recombinant human CIRBP protein
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human CIRBP
- Species Reactivity
- Human
- Clone
- R01-4B2
- Applications
- Western Blot, Immunohistochemistry-Paraffin, Immunoprecipitation
- MW
- The calculated weight of the target protein is approximately 19 kDa, while the observed molecular weight stands at 19 kDa.
- Related Disease
- Cryptorchidism, Unilateral Or Bilateral
Product Property
- Purification
- Affinity Purified
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Western Blot: 1/500-1/1000
Immunohistochemistry: 1/50-1/100
Immunoprecipitation: 1/20
Target
- Alternative Names
- Cold Inducible RNA Binding Protein; Cold-Inducible RNA-Binding Protein; Glycine-Rich RNA Binding Protein; A18 HnRNP; CIRP; Glycine-Rich RNA-Binding Protein CIRP; Cold Inducible RNA-Binding Protein; Testicular Tissue Protein Li 39; A18HNRNP
- Gene ID
- 1153
- UniProt ID
- Q14011
- Cellular Localization
- Cytoplasm, Nucleus
- Post Translation Modifications
- Methylated on arginine residues. Methylation of the RGG motifs is a prerequisite for recruitment into SGs ().
Phosphorylated by CK2, GSK3A and GSK3B. Phosphorylation by GSK3B increases RNA-binding activity to the TXN 3'-UTR transcript upon exposure to UV radiation.
- Protein Refseq
- XP_006722700.1; XP_011525970.1; XP_016881726.1; XP_054175689.1; XP_054175690.1
- Function
- Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Acts as a translational activator. Seems to play an essential role in cold-induced suppression of cell proliferation. Binds specifically to the 3'-untranslated regions (3'-UTRs) of stress-responsive transcripts RPA2 and TXN. Acts as a translational repressor (By similarity).
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "CIRBP"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS7-HM737 | Mouse Anti-CIRBP Recombinant Antibody (clone 6E12D5) | IHC | Mouse IgG1 |
| VS7-HM738 | Mouse Anti-CIRBP Recombinant Antibody (clone 6E12B3) | WB, IHC | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY457 | Anti-CIRBP Immunohistochemistry Kit | IHC | |
| VS-0525-XY1464 | Anti-Human CIRBP Immunohistochemistry Kit | IHC |
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