Rabbit Anti-CIRBP Recombinant Antibody (clone R01-4B2) (CAT#: VS3-FY1687)

• Immunogen
• Recombinant human CIRBP protein

• Host Species
• Rabbit

• Type
• Rabbit IgG

• Specificity
• Human CIRBP

• Species Reactivity
• Human

• Clone
• R01-4B2

• Applications
• Western Blot, Immunohistochemistry-Paraffin, Immunoprecipitation

• MW
• The calculated weight of the target protein is approximately 19 kDa, while the observed molecular weight stands at 19 kDa.

• Related Disease
• Cryptorchidism, Unilateral Or Bilateral

• Purification
• Affinity Purified

• Format
• Liquid

• Concentration
• Please refer to the vial label for the specific concentration.

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Application Notes
• Western Blot: 1/500-1/1000
  Immunohistochemistry: 1/50-1/100
  Immunoprecipitation: 1/20

• Alternative Names
• Cold Inducible RNA Binding Protein; Cold-Inducible RNA-Binding Protein; Glycine-Rich RNA Binding Protein; A18 HnRNP; CIRP; Glycine-Rich RNA-Binding Protein CIRP; Cold Inducible RNA-Binding Protein; Testicular Tissue Protein Li 39; A18HNRNP

• Gene ID
• 1153

• UniProt ID
• Q14011

• Cellular Localization
• Cytoplasm, Nucleus

• Post Translation Modifications
• Methylated on arginine residues. Methylation of the RGG motifs is a prerequisite for recruitment into SGs ().
  Phosphorylated by CK2, GSK3A and GSK3B. Phosphorylation by GSK3B increases RNA-binding activity to the TXN 3'-UTR transcript upon exposure to UV radiation.

• Protein Refseq
• XP_006722700.1; XP_011525970.1; XP_016881726.1; XP_054175689.1; XP_054175690.1

• Function
• Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Acts as a translational activator. Seems to play an essential role in cold-induced suppression of cell proliferation. Binds specifically to the 3'-untranslated regions (3'-UTRs) of stress-responsive transcripts RPA2 and TXN. Acts as a translational repressor (By similarity).

Isotype Control

• MOB-208CQ
• Rabbit IgG Isotype Control Antibody

Secondary Antibody

• 2ND-054CQ
• Goat Anti-Rabbit IgG Antibody, R-PE

• 2ND-059CQ
• Goat Anti-Rabbit IgG (H&L) Antibody

• 2ND-055CQ
• Chicken Anti-Rabbit IgG (H&L) Antibody

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