Human Anti-Citrullinated epitope Recombinant Antibody (clone C07) (CAT#: HPAB-AP043-YC)
Autoimmune reactions to certain epitopes of self antigens most likely contribute to the development of rheumatoid arthritis. Often these epitopes are citrullinated. Provided is a novel antibody C07 that can bind to certain citrullinated epitopes namely citrullinated enolase, vimentin, fibrinogen and citrullinated synthetic peptides. The antibody may also be an antibody that has reactivity against only CEP-1, CCP and cit-vim such as antibody C07. The antibody can be used in diagnostics of rheumatoid arthritis, for therapy against rheumatoid arthritis and as research tools.
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Custom Production
We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.
We require custom production
Specifications
- Host Species
- Human
- Type
- Human IgG
- Specificity
- Human Citrullinated epitope
- Species Reactivity
- Human
- Clone
- C07
- Applications
- ELISA
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- The Citrullinated epitopes antibody has been reported in applications of Immunohistochemistry, Immunofluorescence, Enzyme-linked Immunosorbent Assay.
For Immunohistochemistry: Cells were fixed with formaldehyde and stained with murinised monoclonal ACPAs (D10, B02, C07), murinised control antibody (E02), rabbit polyclonal anti-PAD2 and monoclonal mouse anti-PADI4 followed by horseradish peroxidase conjugated antimouse antibody as a secondary antibody and 3,3-diaminobenzidene (DAB). The slides were counterstained with Mayer's haematoxylin and viewed using a light microscope.
For Immunofluorescence: The cells were incubated with the murinised ACPAs, polyclonal ACPA and anti-CD68 monoclonal antibody, followed by Alexa-Fluor-633-labeled secondary antibodies (Abcam) and counterstained with 4′,6-diamidino-2-phenylindole.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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IgG Antibody Products
ScFv Antibody Products
Fab Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-AP052-YC | Human Anti-Citrullinated epitope Recombinant Antibody (clone C02) | ELISA | Human IgG |
| HPAB-AP053-YC | Human Anti-Citrullinated epitope Recombinant Antibody (clone A09) | ELISA | Human IgG |
| HPAB-AP054-YC | Human Anti-Citrullinated epitope Recombinant Antibody (clone D09) | ELISA | Human IgG |
| HPAB-AP055-YC | Human Anti-Citrullinated epitope Recombinant Antibody (clone A02) | ELISA | Human IgG |
| HPAB-AP605-YC | Mouse Anti-Citrullinated epitope Recombinant Antibody (HPAB-AP605-YC) | ELISA, IHC, WB | Mouse IgG |
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For Research Use Only. Not For Clinical Use.
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