Rabbit Anti-CLDN11 Polyclonal Antibody (CAT#: VS3-WK1569)
This antibody is a rabbit polyclonal antibody against human CLDN11, which is a major component of central nervous system (CNS) myelin and plays an important role in regulating proliferation and migration of oligodendrocytes. It was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen (synthesized peptide derived from human CLDN11). It can detect endogenous levels of CLDN11. This product was tested for use in WB and ELISA.
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Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line HUVEC TERT2
(Immunofluorescent staining of human cell line HUVEC TERT2 shows localization to cell junctions & lipid droplets.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13657/1878_C6_27_cr5b8037792853b_selected.jpg
(Immunofluorescent staining of human cell line HUVEC TERT2 shows localization to cell junctions & lipid droplets.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13657/1878_C6_27_cr5b8037792853b_selected.jpg
Figure 2 Cerebral cortex
(Neuropil Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13166/30677_B_9_5.jpg
(Neuropil Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13166/30677_B_9_5.jpg
Figure 3 Colon
(Enterocytes - Mucosal lymphoid cells Staining: Low Intensity: Moderate Quantity: <25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13166/30677_A_7_3.jpg
(Enterocytes - Mucosal lymphoid cells Staining: Low Intensity: Moderate Quantity: <25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13166/30677_A_7_3.jpg
Figure 4 High expression in testis
(Sertoli cells Staining: High Intensity: Strong Quantity:>75%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13166/30677_A_6_6.jpg
(Sertoli cells Staining: High Intensity: Strong Quantity:>75%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13166/30677_A_6_6.jpg
Figure 5 Lymph node
(Germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous nuclear Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13166/30677_A_7_8.jpg
(Germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous nuclear Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13166/30677_A_7_8.jpg
Figure 6 RNA cell line category: Cell line enhanced (ASC diff, ASC TERT1, EFO-21, HUVEC TERT2, TIME)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000013297-CLDN11
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000013297-CLDN11
Specifications
- Immunogen
- Synthesized peptide derived from human Claudin 11
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human CLDN11
- Species Reactivity
- Human, Mouse, Rat
- Applications
- WB, ELISA
- Conjugate
- Unconjugated
Product Property
- Clonality
- Polyclonal
- Purification
- Affinity purified
- Purity
- >95% as determined by SDS-PAGE
- Aggregation
- < 5%
- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- PBS, 0.5% BSA, 50% Glycerol
- Preservative
- 0.02% Sodium Azide
- Storage
- Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- This antibody has been tested for use in Western Blot (1:500) and ELISA (1:10000-1/20000).
Target
- Alternative Names
- Claudin 11; Oligodendrocyte Transmembrane Protein; Oligodendrocyte-Specific Protein; OTM; OSP; Claudin-11
- Gene ID
- 5010
- UniProt ID
- O75508
- Long Name
- Claudin 11
- Sequence Similarities
- Belongs to the claudin family.
- Cellular Localization
- Cell junction, Cell membrane, Membrane, Tight junction
- Protein Refseq
- NP_005593.2
- Function
- Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
Recommended Products
Secondary Antibody
Isotype Control
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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IgG Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1801z | Mouse Anti-CLDN11 Recombinant Antibody (clone 39G9) | WB, ELISA, IF, IP | Mouse IgA, κ |
| VS3-XY3318 | Rabbit Anti-CLDN11 Recombinant Antibody (clone R09-1E7) | WB, FC | Rabbit IgG |
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