Rabbit Anti-CLDN11 Polyclonal Antibody (CAT#: VS3-WK1569)
This antibody is a rabbit polyclonal antibody against human CLDN11, which is a major component of central nervous system (CNS) myelin and plays an important role in regulating proliferation and migration of oligodendrocytes. It was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen (synthesized peptide derived from human CLDN11). It can detect endogenous levels of CLDN11. This product was tested for use in WB and ELISA.
Specific Inquiry
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line HUVEC TERT2
(Immunofluorescent staining of human cell line HUVEC TERT2 shows localization to cell junctions & lipid droplets.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13657/1878_C6_27_cr5b8037792853b_selected.jpg
(Immunofluorescent staining of human cell line HUVEC TERT2 shows localization to cell junctions & lipid droplets.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13657/1878_C6_27_cr5b8037792853b_selected.jpg
Figure 2 Cerebral cortex
(Neuropil Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13166/30677_B_9_5.jpg
(Neuropil Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13166/30677_B_9_5.jpg
Figure 3 Colon
(Enterocytes - Mucosal lymphoid cells Staining: Low Intensity: Moderate Quantity: <25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13166/30677_A_7_3.jpg
(Enterocytes - Mucosal lymphoid cells Staining: Low Intensity: Moderate Quantity: <25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13166/30677_A_7_3.jpg
Figure 4 High expression in testis
(Sertoli cells Staining: High Intensity: Strong Quantity:>75%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13166/30677_A_6_6.jpg
(Sertoli cells Staining: High Intensity: Strong Quantity:>75%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13166/30677_A_6_6.jpg
Figure 5 Lymph node
(Germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous nuclear Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13166/30677_A_7_8.jpg
(Germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous nuclear Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13166/30677_A_7_8.jpg
Figure 6 RNA cell line category: Cell line enhanced (ASC diff, ASC TERT1, EFO-21, HUVEC TERT2, TIME)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000013297-CLDN11
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000013297-CLDN11
Specifications
- Immunogen
- Synthesized peptide derived from human Claudin 11
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human CLDN11
- Species Reactivity
- Human, Mouse, Rat
- Applications
- WB, ELISA
- Conjugate
- Unconjugated
Product Property
- Clonality
- Polyclonal
- Purification
- Affinity purified
- Purity
- >95% as determined by SDS-PAGE
- Aggregation
- < 5%
- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- PBS, 0.5% BSA, 50% Glycerol
- Preservative
- 0.02% Sodium Azide
- Storage
- Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- This antibody has been tested for use in Western Blot (1:500) and ELISA (1:10000-1/20000).
Target
- Alternative Names
- Claudin 11; Oligodendrocyte Transmembrane Protein; Oligodendrocyte-Specific Protein; OTM; OSP; Claudin-11
- Gene ID
- 5010
- UniProt ID
- O75508
- Long Name
- Claudin 11
- Sequence Similarities
- Belongs to the claudin family.
- Cellular Localization
- Cell junction, Cell membrane, Membrane, Tight junction
- Protein Refseq
- NP_005593.2
- Function
- Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
Recommended Products
Secondary Antibody
Isotype Control
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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IgG Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1801z | Mouse Anti-CLDN11 Recombinant Antibody (clone 39G9) | WB, ELISA, IF, IP | Mouse IgA, κ |
| VS3-XY3318 | Rabbit Anti-CLDN11 Recombinant Antibody (clone R09-1E7) | WB, FC | Rabbit IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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